Der Radiologe

, Volume 44, Issue 10, pp 975–984 | Cite as

Stellenwert der MR-Angiographie zur Diagnose bei Karotisstenosen

  • H. J. Michaely
  • K. A. Herrmann
  • H. Kramer
  • G. Laub
  • M. F. Reiser
  • S. O. Schoenberg
Karotisstenosen

Zusammenfassung

Arteriosklerose der hirnversorgenden Gefäße ist ein nachgewiesener Risikofaktor für zerebrovaskuläre Erkrankungen. Große Multicenterstudien wie NASCET und ECST belegen den protektiven Nutzen chirurgischer Therapie von schweren (>70%) Karotisstenosen. Die genaue Detektierung und Graduierung von Karotisstenosen ist die Voraussetzung für eine erfolgreiche Therapie. Neben dem Goldstandard, der digitalen Subtraktionsangiographie (DSA), wird hierfür immer häufiger die MR-Angiographie (MRA) angewandt, mit der nichtinvasiv und ohne ionisierende Strahlung eine hochauflösende Gefäßdarstellung der Halsgefäße in nur 20 s durchgeführt werden kann. Dieser Beitrag erläutert zunächst die hierfür verwendeten MRA-Techniken, die Anwendungsmöglichkeiten und Limitationen. Anschließend wird die diagnostische Genauigkeit der MRA verglichen mit der DSA sowie dem Ultraschall. Die klinische Wertigkeit der MRA für die Diagnostik der Karotisstenosen wird dann anhand von Beispielen kritisch diskutiert.

Schlüsselwörter

MRA Karotisstenose Digitale Subtraktionsangiographie Ultraschall Parallele Bildgebung 

The significance of MR angiography for the diagnosis of carotid stenoses

Abstract

Arteriosclerosis of the supra-aortic vessels is a known risk factor for cerebrovascular disease. Large multicenter studies like NASCET and ECST have proven the protective effects of the surgical treatment of severe (>70%) carotid artery stenoses. The exact detection and grading of stenoses of the carotid arteries is a prerequisite for a successful therapy. Besides the gold-standard examination, digital subtraction angiography (DSA), MR angiography (MRA) is being used increasingly. MRA allows a non-invasive, high-resolution depiction of the supra-aortic vessels without ionizing radiation in only 20 s. This article first illustrates the MRA-techniques, and the indications and limitations of MRA. Next, the diagnostic accuracy of MRA is compared to DSA and ultrasound. The clinical value of MRA for the detection of stenoses of the carotid arteries is discussed on the basis of clinical examples.

Keywords

MRA Carotid artery stenosis Digital subtraction angiography Ultrasound Parallel imaging 

Notes

Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

Literatur

  1. 1.
    North American Symptomatic Carotid Endarterectomy Trial (NASCET) investigators (1991) Clinical alert: benefit of carotid endarterectomy for patients with high-grade stenosis of the internal carotid artery. National Institute of Neurological Disorders and Stroke and Trauma Division. Stroke 22: 816–817PubMedGoogle Scholar
  2. 2.
    Barer D (1998) Endarterectomy for recently symptomatic carotid stenosis. Lancet 352: 143–144CrossRefGoogle Scholar
  3. 3.
    U-King-Im JM, Hollingworth W, Trivedi RA et al. (2004) Contrast-enhanced MR angiography vs intra-arterial digital subtraction angiography for carotid imaging: activity-based cost analysis. Eur Radiol 14: 730–735Google Scholar
  4. 4.
    Willinsky RA, Taylor SM, TerBrugge K, Farb RI, Tomlinson G, Montanera W (2003) Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature. Radiology 227: 522–528PubMedGoogle Scholar
  5. 5.
    Waugh JR, Sacharias N (1992) Arteriographic complications in the DSA era. Radiology 182: 243–246Google Scholar
  6. 6.
    Wedeen VJ, Meuli RA, Edelman RR, Geller SC, Frank LR, Brady TJ, Rosen BR (1985) Projective imaging of pulsatile flow with magnetic resonance. Science 230: 946–948PubMedGoogle Scholar
  7. 7.
    Patel MR, Kuntz KM, Klufas RA et al. (1995) Preoperative assessment of the carotid bifurcation. Can magnetic resonance angiography and duplex ultrasonography replace contrast arteriography? Stroke 26: 1753–1758PubMedGoogle Scholar
  8. 8.
    Saloner D (1998) Determinants of image appearance in contrast-enhanced magnetic resonance angiography. A review. Invest Radiol 33: 488–495CrossRefPubMedGoogle Scholar
  9. 9.
    Krinsky GA, Kaminer E, Lee VS, Rofsky NM, Weinreb JC (1998) The effects of apnea on timing examinations for optimization of gadolinium-enhanced MRA of the thoracic aorta and arch vessels. J Comput Assist Tomogr 22: 677–681CrossRefPubMedGoogle Scholar
  10. 10.
    Riederer SJ, Bernstein MA, Breen JF et al. (2000) Three-dimensional contrast-enhanced MR angiography with real-time fluoroscopic triggering: design specifications and technical reliability in 330 patient studies. Radiology 215: 584–593PubMedGoogle Scholar
  11. 11.
    Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P (1999) SENSE: sensitivity encoding for fast MRI. Magn Reson Med 42: 952–962CrossRefPubMedGoogle Scholar
  12. 12.
    Griswold MA, Jakob PM, Heidemann RM et al. (2002) Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 47: 1202–1210CrossRefPubMedGoogle Scholar
  13. 13.
    Korosec FR, Frayne R, Grist TM, Mistretta CA (1996) Time-resolved contrast-enhanced 3D MR angiography. Magn Reson Med 36: 345–351PubMedGoogle Scholar
  14. 14.
    Kim DY, Park JW (2004) Computerized quantification of carotid artery stenosis using MRA axial images. Magn Reson Imaging 22: 353–359CrossRefPubMedGoogle Scholar
  15. 15.
    Schoenberg SO, Rieger J, Weber C, Michaely HJ, Waggershauser T, Nitka M, Reiser MF (2004) High-resolution MRA of the renal arteries using parallel acquisition techniques: value of isotropic cross-sectional reformats compared to digital subtraction angiography and intravascular ultrasound. Proc Int Soc Magn Reson Med 235Google Scholar
  16. 16.
    U-King-Im JM, Trivedi R, Cross J et al. (2004) Conventional digital subtraction x-ray angiography versus magnetic resonance angiography in the evaluation of carotid disease: patient satisfaction and preferences. Clin Radiol 59: 358–363CrossRefPubMedGoogle Scholar
  17. 17.
    U-King-Im JM, Trivedi RA, Graves MJ et al. (2004) Contrast-enhanced MR angiography for carotid disease: diagnostic and potential clinical impact. Neurology 62: 1282–1290PubMedGoogle Scholar
  18. 18.
    Nederkoorn PJ, van der Graaf Y, Hunink MG (2003) Duplex ultrasound and magnetic resonance angiography compared with digital subtraction angiography in carotid artery stenosis: a systematic review. Stroke 34: 1324–1332CrossRefGoogle Scholar
  19. 19.
    Back MR, Wilson JS, Rushing G, Stordahl N, Linden C, Johnson BL, Bandyk DF (2000) Magnetic resonance angiography is an accurate imaging adjunct to duplex ultrasound scan in patient selection for carotid endarterectomy. J Vasc Surg 32: 429–438; discussion 439–440CrossRefPubMedGoogle Scholar
  20. 20.
    Nederkoorn PJ, Elgersma OE, Mali WP, Eikelboom BC, Kappelle LJ, van der Graaf Y (2002) Overestimation of carotid artery stenosis with magnetic resonance angiography compared with digital subtraction angiography. J Vasc Surg 36: 806–813CrossRefPubMedGoogle Scholar
  21. 21.
    Anderson CM, Lee RE, Levin DL, de la Torre Alonso S, Saloner D (1994) Measurement of internal carotid artery stenosis from source MR angiograms. Radiology 193: 219–226PubMedGoogle Scholar
  22. 22.
    van Everdingen KJ, Klijn CJ, Kappelle LJ, Mali WP, van der Grond J (1997) MRA flow quantification in patients with a symptomatic internal carotid artery occlusion. The Dutch EC-IC Bypass Study Group. Stroke 28: 1595–1600PubMedGoogle Scholar
  23. 23.
    Vanninen R, Koivisto K, Tulla H, Manninen H, Partanen K (1995) Hemodynamic effects of carotid endarterectomy by magnetic resonance flow quantification. Stroke 26: 84–89PubMedGoogle Scholar
  24. 24.
    Aschenbach R, Eger C, Basche S, Vogl TJ (2004) Grading of carotid artery stenosis using high resolution dynamic magnetic resonance angiography in comparison to intraarterial digital subtraction angiography. Are stenoses over 70% reliably detectable? Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 176: 357–362CrossRefPubMedGoogle Scholar
  25. 25.
    Alvarez-Linera J, Benito-Leon J, Escribano J, Campollo J, Gesto R (2003) Prospective evaluation of carotid artery stenosis: elliptic centric contrast-enhanced MR angiography and spiral CT angiography compared with digital subtraction angiography. AJNR Am J Neuroradiol 24: 1012–1019PubMedGoogle Scholar
  26. 26.
    Troyer A, Saloner D, Pan XM, Velez P, Rapp JH (2002) Major carotid plaque surface irregularities correlate with neurologic symptoms. J Vasc Surg 35: 741–747CrossRefPubMedGoogle Scholar
  27. 27.
    Ersoy H, Watts R, Sanelli P, Zimmerman RD, Kent KC, Bush HL, Prince MR (2003) Atherosclerotic disease distribution in carotid and vertebrobasilar arteries: clinical experience in 100 patients undergoing fluoro-triggered 3D Gd-MRA. J Magn Reson Imaging 17: 545–558CrossRefPubMedGoogle Scholar
  28. 28.
    Slovut DP, Olin JW (2004) Fibromuscular dysplasia. N Engl J Med 350: 1862–1871CrossRefPubMedGoogle Scholar
  29. 29.
    Zuccoli G, Guidetti D, Nicoli F, Giovanardi F, Ferrozzi F (2002) Carotid and vertebral artery dissection: Magnetic resonance findings in 15 cases. Radiol Med (Torino) 104: 466–471Google Scholar

Copyright information

© Springer Medizin Verlag 2004

Authors and Affiliations

  • H. J. Michaely
    • 1
    • 3
  • K. A. Herrmann
    • 1
  • H. Kramer
    • 1
  • G. Laub
    • 2
  • M. F. Reiser
    • 1
  • S. O. Schoenberg
    • 1
  1. 1.Institut für Klinische RadiologieKlinikum der Universität München—Großhadern
  2. 2.Siemens Medical SolutionsMalvernUSA
  3. 3.Institut für Klinische RadiologieKlinikum der Universität München—GroßhadernMünchen

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