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Wie Schlaf und Alzheimer-Krankheit zusammenhängen

Insomnie, Amnesie und Amyloid

Connections between sleep and Alzheimerʼs disease

Insomnia, amnesia and amyloid

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Zusammenfassung

Schlaf spielt eine essenzielle Rolle bei der Gedächtniskonsolidierung. Störungen des Schlafs sind im Verlauf der Alzheimer-Krankheit zwar häufig, gelten bislang aber eher als „Nebenschauplatz“ und nicht als wesentliches Merkmal der Krankheit. Neueste Erkenntnisse der experimentellen Forschung zeigen jedoch, dass Schlafstörungen nicht nur den typischen kognitiven Defiziten vorangehen, sondern sogar im Zusammenhang mit der Pathogenese der Alzheimer-Krankheit stehen sowie Symptome und Verlauf entscheidend beeinflussen können. Schlafstörungen verdienen daher als potenziell modifizierbare Risikofaktoren der Alzheimer-Krankheit mehr Aufmerksamkeit in Forschung, Diagnostik und Therapie.

Abstract

Sleep plays an essential role in memory consolidation. Although sleep problems are common in Alzheimerʼs disease, they are not usually thought to be key features of the disease; however, new experimental research has shown that sleep disturbances not only occur before the onset of typical cognitive deficits but are also associated with the pathogenesis of Alzheimerʼs disease and may have a decisive influence on the symptoms and course. Thus, sleep disturbances may be potentially modifiable risk factors for Alzheimerʼs disease that deserve more attention in research, diagnostics and treatment.

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Authors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, München, Deutschland

    M. A. Busche & H. Förstl

  2. Institut für Neurowissenschaften, Technische Universität München, München, Deutschland

    M. A. Busche & M. Kekuš

  3. Munich Cluster for Systems Neurology (SyNergy), München, Deutschland

    M. A. Busche & M. Kekuš

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  1. M. A. Busche
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  2. M. Kekuš
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Correspondence to M. A. Busche.

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M.A. Busche und M. Kekuš und H. Förstl geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Busche, M.A., Kekuš, M. & Förstl, H. Wie Schlaf und Alzheimer-Krankheit zusammenhängen. Nervenarzt 88, 215–221 (2017). https://doi.org/10.1007/s00115-016-0122-0

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