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Der Nervenarzt

, Volume 85, Issue 3, pp 336–343 | Cite as

Serotonintransportergen und Stressreagibilität bei unipolarer Depression

Rolle des HPA-Systems als Endophänotyp des Gens SLC6A4
  • H. WelperEmail author
  • A. Aller
  • V. Guttenthaler
  • S. Höfels
  • L. Lennertz
  • U. Pfeiffer
  • S. G. Schwab
  • A. Zobel
Originalien

Zusammenfassung

Hintergrund

Ein Längenpolymorphismus in der Promoterregion des Serotonintransportergens (5-HTTLPR) wird sowohl mit der Depression als auch mit der Stressreagibilität in Verbindung gebracht. Gleichzeitig gilt eine Dysregulation des Hypothalamic-pituitary-adrenal(HPA)-Systems als Endophänotypkandidat der Depression. Ziel der vorliegenden Studie war es, einen möglichen Einfluss des 5-HTTLPR-Genotyps auf die HPA-Systemaktivität bei akut depressiv erkrankten Patienten zu untersuchen und Aussagen hinsichtlich einer möglichen Gen-Endophänotypen-Interaktion zu treffen.

Material und Methoden

Es wurden 273 Patienten einer akuten Major-Depression hinsichtlich der 5-HTTLPR genotypisiert und nahmen an einem Dexamethason-corticotropin-releasing-hormone(Dex-CRH)-Test sowie einer Erhebung des Schweregrads psychopathologischer Merkmale mithilfe der Hamilton-Skala (Hamilton Rating Scale for Depression) teil.

Ergebnisse

Patienten mit einem ss-Genotyp zeigten eine signifikant höhere HPA-Systemaktivität als Patienten mit einem ll-Genotyp. Im Hinblick auf den Schweregrad psychopathologischer Merkmale konnte kein derartiger Effekt ermittelt werden.

Schlussfolgerung

Die Studienergebnisse zeigen einen Einfluss der 5-HTTLPR auf die HPA-Systemaktivität in einer Gruppe depressiv erkrankter Patienten und unterstützen die Hypothese einer Interaktion zwischen den 5-HTTLPR-Genotypen und der HPA-Systemaktivität bei der Pathophysiologie der Depression.

Schlüsselwörter

Depression Endophänotyp Serotonintransportergen HPA-System Dexamethason-corticotropin-releasing-hormone-Test 

Serotonin transporter gene and stress reactivity in unipolar depression

Role of the HPA system as endophenotype of the SLC6A4 gene

Summary

Background

A length polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) is associated with both depression and hypothalamic-pituitary-adrenal (HPA) system activity. A dysregulation of the HPA system is considered to be a candidate endophenotype of depression. The objective of the present study was an investigation of a possible gene-endophenotype-interaction between 5-HTTLPR and HPA system activity in a sample of inpatients with major depression.

Materials and methods

A total of 237 inpatients with major depression were genotyped for 5-HTTLPR and participated in a combined dexamethasone-corticotropin-releasing hormone test (Dex-CRH test) as well as using the Hamilton score (Hamilton rating scale for depression) to determine the severity of the psychopathology.

Results

Patients with the ss-genotype showed a significantly higher HPA -system activity in comparison to patients with the lI–genotype, but no association between 5-HTTLPR and the severity of psychopathology could be detected.

Conclusions

The results of the current study demonstrate an influence of 5-HTTLPR on dysregulation of the HPA system in patients with major depression and support the hypothesis that 5-HTTLPR- and HPA-system-interaction constitutes an important component in the pathogenesis of depression.

Keywords

Depression Endophenotype Serotonin transporter gene Hypothalamic-pituitary-adrenal axis  Dexamethasone-corticotropin-releasing hormone test 

Notes

Interessenkonflikt

Die korrespondierende Autorin gibt für sich und ihre Koautoren an, dass kein Interessenkonflikt besteht.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • H. Welper
    • 1
    • 2
    Email author
  • A. Aller
    • 1
  • V. Guttenthaler
    • 1
  • S. Höfels
    • 1
  • L. Lennertz
    • 1
  • U. Pfeiffer
    • 1
  • S. G. Schwab
    • 1
    • 3
  • A. Zobel
    • 1
  1. 1.Klinik und Poliklinik für Psychiatrie und PsychotherapieUniversitätsklinikum BonnBonnDeutschland
  2. 2.Klinik für Psychiatrie und Psychotherapie des Kindes- und JugendaltersUniversität LeipzigLeipzigDeutschland
  3. 3.Psychiatrische und Psychotherapeutische KlinikUniversität ErlangenErlangenDeutschland

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