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, Volume 78, Issue 10, pp 1200–1208 | Cite as

FTY720 (Fingolimod) als neue Therapiemöglichkeit der Multiplen Sklerose

  • J. Klatt
  • H.-P. Hartung
  • R. Hohlfeld
Aktuelles

Zusammenfassung

Sämtliche zurzeit für die Behandlung der Multiplen Sklerose zugelassenen Substanzen stehen nur in parenteraler Applikationsform zur Verfügung. Verschiedene orale Substanzen befinden sich in der klinischen Entwicklung. Eine dieser Substanzen, FTY720 (auch bekannt als Fingolimod), wird in dieser Übersicht näher beleuchtet. Es werden zunächst die biologischen Effekte von FTY720 dargestellt, im Anschluss folgen tierexperimentelle und klinische Daten. FTY720 als ein Sphingosin-1-Phosphat-Rezeptor-Agonist basiert auf einem innovativen Ansatz und greift an verschiedenen Stellen in die pathogenetische Kaskade der Multiplen Sklerose ein. In einer bislang vorliegenden Phase-II-Studie zeigt FTY720 eine viel versprechende Wirksamkeit mit einer Schubreduktion von über 50% im Vergleich zu Plazebo bei akzeptabler Verträglichkeit. Diese Ergebnisse sollen in zwei laufenden internationalen Phase-III-Studien bestätigt werden.

Schlüsselwörter

Multiple Sklerose Sphingosin-1-Phosphat FTY720 Fingolimod Orale Behandlung 

FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis

Summary

All currently available therapeutic options for multiple sclerosis have to be administered parenterally. Several oral substances are currently in the late clinical development stage. One of them, FTY720 (also known as fingolimod) is highlighted in this review. The biological effects of FTY720 are presented as well as animal data and first clinical data from a phase II trial in multiple sclerosis patients. The effects of FTY720 are based on an innovative approach and apparently target several key elements in the pathogenesis of multiple sclerosis. The first clinical data with FTY720 show very promising results, with a relapse reduction of over 50% compared to placebo and an acceptable safety profile. These results currently await confirmation in two international phase III studies which are recruiting patients worldwide.

Keywords

Multiple sclerosis Oral treatment FTY720 Fingolimod Sphingosine-1-phosphate 

Notes

Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung/en hin: J. Klatt arbeitet in der klinischen Forschung bei der Novartis GmbH und leitet das Studienprogramm in Deutschland für FTY720. Prof. H.-P. Hartung und Prof. R. Hohlfeld sind beide als Leiter der klinischen Prüfung für FTY720 tätig und haben von der Novartis Pharma GmbH eine entsprechende Honorierung hierfür sowie für Beratungstätigkeiten erhalten.

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Copyright information

© Springer Medizin Verlag 2007

Authors and Affiliations

  1. 1.Novartis Pharma GmbH NürnbergNürnbergDeutschland
  2. 2.Neurologische KlinikHeinrich-Heine-Universität DüsseldorfDüsseldorfDeutschland
  3. 3.Institut für Klinische NeuroimmunologieKlinikum der LMU München, GroßhadernMünchenDeutschland

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