Horses and cows might teach us about human knees
- 443 Downloads
Our comparative study of the knees of horses and cows (paraphrased as highly evolved joggers and as domesticated couch-potatoes, respectively) demonstrates significant differences in the posterior sections of bovine and equine tibial cartilage, which are consistent with specialisation for gait. These insights were possible using a novel analytical measuring technique based on the shearing of small biopsy samples, called dynamic shear analysis. We assert that this technique could provide a powerful new tool to precisely quantify the pathology of osteoarthritis for the medical field.
KeywordsDynamic shear analysis Osteoarthritis Cartilage
We thank the United States Air Force Office of Scientific Research (FA9550-09-1-0111), Magdalen College Oxford, the European Research Council (SP2-GA-2008-233409), NIHR Biomedical Research Unit into Musculoskeletal Disease, Nuffield Orthopaedic Centre and University of Oxford for funding.
- Muraki S, Akune T, Oka H, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N (2010) Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: the ROAD study. Osteoarthr Cartil 18(9):1227–1234PubMedCrossRefGoogle Scholar
- Pough FH, Heiser JB, McFarland WN (1989) Vertebrate life, 3rd edn. MacMillan Publishing Company, New YorkGoogle Scholar
- Southwood R (2003) The story of life, 1st edn. Oxford University Press, OxfordGoogle Scholar
- White SH, Ludkowski PF, Goodfellow JW (1991) Anteromedial osteoarthritis of the knee. J Bone Joint Surg 73-B(4):582–586Google Scholar