Revisiting chronodisruption: when the physiological nexus between internal and external times splits in humans
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In this Concepts & Synthesis paper, we expand the definition of chronodisruption in humans by proposing that it can be operationalized as the split nexus of internal and external times. With this premise, we suggest how chronotype may be used as a temporal marker (chronomarker) of exposure to chronodisruption in studies of cancer, and beyond, offer cancer risk predictions for observational research on the basis of a chronotype-related hypothesis and corollary, and point to first empirical data in humans. In an a priori way, we examine possible outcomes and perspectives for preventive measures following from our rationale and the suggested chronobiology-driven studies and close with overall advances of chronodisruption research.
KeywordsChronodisruption Internal time External time Chronotype Health Disease Cancer Shift work
TCE and RJR conceived and developed this Concepts & Synthesis paper together and approve of the final manuscript. We thank anonymous reviewers for their constructive suggestions.
- Erren TC (2013) Shift work and cancer research: can chronotype predict susceptibility in night-shift and rotating-shift workers? Occup Environ Med (in press)Google Scholar
- Fontana A, Copetti M, Mazzoccoli G, Kypraios T, Pellegrini F (2012) A linear mixed model approach to compare the evolution of multiple biological rhythms. Stat Med. doi: 10.1002/sim.5712
- Juda M, Vetter C, Roenneberg T (2013) The Munich Chronotype Questionnaire for Shift-workers (MCTQShift). J Biol Rhythms In pressGoogle Scholar
- Kantermann T, Juda M, Vetter C, Roenneberg T (2010) Shift work research: where do we stand, where should we go? Sleep Biol Rhythms 8:95–105Google Scholar
- World Health Organization, International Agency for Research on Cancer (2010) IARC monographs on the evaluation of carcinogenic risks to humans. Volume 98. Painting firefighting, and shiftwork. IARC, LyonGoogle Scholar