Naturwissenschaften

, Volume 94, Issue 7, pp 517–526

Getting ready for the manned mission to Mars: the astronauts’ risk from space radiation

Review

Abstract

Space programmes are shifting towards planetary exploration and, in particular, towards missions by human beings to the Moon and to Mars. Radiation is considered to be one of the major hazards for personnel in space and has emerged as the most critical issue to be resolved for long-term missions both orbital and interplanetary. The two cosmic sources of radiation that could impact a mission outside the Earth’s magnetic field are solar particle events (SPE) and galactic cosmic rays (GCR). Exposure to the types of ionizing radiation encountered during space travel may cause a number of health-related problems, but the primary concern is related to the increased risk of cancer induction in astronauts. Predictions of cancer risk and acceptable radiation exposure in space are extrapolated from minimal data and are subject to many uncertainties. The paper describes present-day estimates of equivalent doses from GCR and solar cosmic radiation behind various shields and radiation risks for astronauts on a mission to Mars.

Keywords

Space Galactic cosmic rays Solar cosmic radiation Astronauts’ radiation risk 

References

  1. Badhwar GD (1997) Deep space radiation sources, models, and environmental uncertainty. In: Wilson JW, Miller J, Konradi A, Cucinotta FA (eds) Shielding strategies for human space exploration. NASA Conference Publication 3360, NASA Langley Research Center, Hampton, VA, USA, pp 17–28Google Scholar
  2. Badhwar GD, O’Neill PM (1994) Long-term modulation of galactic cosmic radiation and its model for space exploration. Adv Space Res 14:749–757PubMedCrossRefGoogle Scholar
  3. Badhwar GD, O’Neill PM (1996) Galactic cosmic radiation model and its applications. Adv Space Res 17:7–17PubMedCrossRefGoogle Scholar
  4. Badhwar GD, Nachtwey DS, Yang TC (1992) Radiation issues for piloted Mars mission. Adv Space Res 12:195–200PubMedCrossRefGoogle Scholar
  5. Baranov DG, Dergachev VA, Gagarin YF, Lyagushin VI, Nymmik RA, Panasyuk MI, Solov’ev AV, Yakubovskii EA (2002) The high-energy heavy-particle fluences in the orbits of manned space stations. Radiat Meas 35:423–431PubMedCrossRefGoogle Scholar
  6. Baumstark-Khan C (1993) X-ray-induced DNA double-strand breaks as lethal lesions in diploid human fibroblasts compared to Chinese hamster ovary cells. Int J Radiat Biol 63:305–311PubMedGoogle Scholar
  7. Baumstark-Khan C, Hellweg CE, Arenz A, Meier MM (2005) Cellular monitoring of the nuclear factor κB pathway for assessment of space environmental radiation. Radiat Res 164:527–530PubMedCrossRefGoogle Scholar
  8. Bazilevskaya GA, Krainev MB, Stozhkov YI, Svirzhevskaya AK, Svirzhevsky NS (1994) Stratospheric measurements of cosmic rays in the 19th–22nd solar activity cycles. Adv Space Res 14:779–782PubMedCrossRefGoogle Scholar
  9. Brooks AL (2003) Developing a scientific basis for radiation risk estimates: major goal of the DOE low dose radiation research program. Intern Cong Ser 1258:287–295CrossRefGoogle Scholar
  10. Brucer M (1964) Definition of the radiation complex. C: the acute radiation syndrome. Conn Med 28:192–202PubMedGoogle Scholar
  11. Casolino M, Bidoli V, Morselli A, Narici L, De Pascale MP, Picozza P, Reali E, Sparvoli R, Mazzenga G, Ricci M, Spillantini P, Boezio M, Bonvicini V, Vacchi A, Zampa N, Castellini G, Sannita WG, Carlson P, Galper A, Korotkov M, Popov A, Vavilov N, Avdeev S, Fuglesang C (2003) Dual origins of light flashes seen in space. Nature 422:680PubMedCrossRefGoogle Scholar
  12. Chaillet MP, Cosset JM, Socie G, Pico JL, Grimaud E, Dubray B, Alapetite C, Girinsky T (1993) Prospective study of the clinical symptoms of therapeutic whole body irradiation. Health Phys 64:370–374PubMedCrossRefGoogle Scholar
  13. Chaudhry MA, Chodosh LA, McKenna WG, Muschel RJ (2003) Gene expression profile of human cells irradiated in G1 and G2 phases of cell cycle. Cancer Lett 195:221–233PubMedGoogle Scholar
  14. Collis SJ, DeWeese TL, Jeggo PA, Parker AR (2005) The life and death of DNA-PK. Oncogene 24:949–961PubMedCrossRefGoogle Scholar
  15. Cronkite EP (1964) The diagnosis, treatment, and prognosis of human radiation injury from whole-body exposure. Ann NY Acad Sci 31:114–341Google Scholar
  16. Cucinotta F, Wilson JW, Williams JR, Dicello JF (2000) Analysis of Mir-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO. Radiat Meas 32:181–191PubMedCrossRefGoogle Scholar
  17. Curtis SB, Atwell W, Beever R, Hardy A (1986) Radiation environments and absorbed dose estimations on manned space missions. Adv Space Res 6:269–274PubMedCrossRefGoogle Scholar
  18. DeGroot RP, Rijken PJ, DenHertog J, Boonstra J, Verkleij AJ, DeLaat SW, Kruijer W (1991) Nuclear responses to protein kinase C signal transduction are sensitive to gravity changes. Exp Cell Res 197:87–90CrossRefGoogle Scholar
  19. Durante M, Snigiryova G, Akaeva E, Bogomazova A, Druzhinin S, Fedorenko B, Greco O, Novitskaya N, Rubanovich A, Shevchenko V, Von Recklinghausen U, Obe G (2006) Chromosome aberration dosimetry in cosmonauts after single or multiple space flights. Cytogenet Genome Res 103:40–46CrossRefGoogle Scholar
  20. Folkard M, Prise KM, Vojnovic B, Gilchrist S, Schettino G, Belyakov OV, Ozols A, Michael BD (2003) The impact of microbeams in radiation biology. Nucl Instrum Methods B 181:426–430CrossRefGoogle Scholar
  21. Friedberg EC (1996) Relationships between DNA repair and transcription. Ann Rev Biochem 65:15–42PubMedCrossRefGoogle Scholar
  22. Friedberg EC, Aguilera A, Gellert M, Hanawalt PC, Hays JB, Lehmann AR, Lindahl T, Lowndes N, Sarasin A, Wood RD (2006) DNA repair: from molecular mechanism to human disease. DNA Repair 5:986–996PubMedCrossRefGoogle Scholar
  23. Fry RJM (1994) Radiation protection guidelines for space activities. Acta Astronaut 32:735–737PubMedCrossRefGoogle Scholar
  24. George K, Durante M, Wu H, Willingham V, Cucinotta FA (2003) In vivo and in vitro measurements of complex-type chromosomal exchanges induced by heavy ions. Adv Space Res 36:1525–1535CrossRefGoogle Scholar
  25. George K, Willingham V, Cucinotta FA (2005) Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome painting. Radiat Res 164:474–480PubMedCrossRefGoogle Scholar
  26. Goodhead DT (1994) Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Radiat Res 65:7–17Google Scholar
  27. Hada M, Sutherland BM (2006) Spectrum of complex DNA damages depends on the incident radiation. Radiat Res 165:223–230PubMedCrossRefGoogle Scholar
  28. Hanawalt PC (1994) Transcription-coupled repair and human disease. Science 266:1957–1958PubMedCrossRefGoogle Scholar
  29. Heynderickx D (2002) Radiation belt modelling in the framework of space weather effects and forecasting. J Atmos Solar-Terr Phys 64:1687–1700CrossRefGoogle Scholar
  30. Horneck G (1998) Biological monitoring of radiation exposure. Adv Space Res 22:1631–1641PubMedCrossRefGoogle Scholar
  31. Horneck G, Facius R, Reichert M, Rettberg P, Seboldt W, Manzey D, Comet B, Maillet A, Preiss H, Schauer L, Dussap CG, Poughon L, Belyavin A, Heer M, Reitz G, Baumstark-Khan C, Gerzer R (2003) HUMEX, a study on the survivability and adaptation of humans to long-duration exploratory missions. ESA-SP1264, ESA Publication DivisionGoogle Scholar
  32. Huntress W, Stetson D, Farquhar R, Zimmerman J, Clark B, O’Neil W, Bourke R, Foing B (2006) The next steps in exploring deep space—a cosmic study by the IAA. Acta Astron 58:304–377CrossRefGoogle Scholar
  33. IARC Study Group on Cancer Risk Among Nuclear Industry Workers (1994) Direct estimates of cancer mortality due to low doses of ionising radiation: an international study. Lancet 344:1039–1043Google Scholar
  34. Karagiannis TC, El-Osta A (2004) Double-strand breaks: signaling pathways and repair mechanisms. Cell Mol Life Sci 61:2137–2147PubMedCrossRefGoogle Scholar
  35. Katz R, Ackerson B, Homayoonfar M, Sharma SC (1971) Inactivation of cells by heavy ion bombardment. Radiat Res 47:402–425PubMedCrossRefGoogle Scholar
  36. Kiefer J, Pross HD (1999) Space radiation effects and microgravity. Mutat Res 430:299–305PubMedGoogle Scholar
  37. Kraft G (1987) Radiobiological effects of very heavy ions: inactivation, induction of chromosome aberrations and strand breaks. Nucl Sci Appl 3:1–28Google Scholar
  38. Lambert B, Holmberg K, Hackman P, Wennborg A (1998) Radiation induced chromosomal instability in human T-lymphocytes. Mutat Res 405:161–170PubMedGoogle Scholar
  39. Lett JT, Lee AC, Cox AB (1994) Risks of radiation cataracts from interplanetary space missions. Acta Astronaut 32:739–748PubMedCrossRefGoogle Scholar
  40. National Council on Radiation Protection and Measurements (1989) Guidance on radiation received in space activities. NCRP, report no. 98Google Scholar
  41. Obe G, Johannes I, Johannes C, Hallman K, Reitz G, Facius R (1997) Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. Int J Radiat Biol 72:727–734PubMedCrossRefGoogle Scholar
  42. Park WY, Hwang CI, Im CN, Kang MJ, Woo JH, Kim JH, Kim YS, Kim JH, Kim H, Kim KA, Yu HJ, Lee SJ, Lee YS, Seo JS (2002) Identification of radiation-specific responses from gene expression profile. Oncogene 21:8521–8528PubMedCrossRefGoogle Scholar
  43. Pellis NR, Goodwin TJ, Risin D, McIntyre BW, Pizzini RP, Cooper D, Baker TL, Spaulding GF (1997) Changes in gravity inhibit lymphocyte locomotion through type I collagen. In Vitro Cell Dev Biol Anim 33:393–405CrossRefGoogle Scholar
  44. Pierce DA, Shimizu Y, Preston DL, Vaeth M, Mabuchi K (1996) Studies of the mortality of atomic bomb survivors. Report 12, part I. Cancer: 1950–1990. Radiat Res 146:l–27Google Scholar
  45. Pippia P, Sciola L, Cogoli-Greuter M, Meloni MA, Spano A, Cogoli A (1996) Activation signals of T-lymphocytes in microgravity. J Biotechnol 47:215–222PubMedCrossRefGoogle Scholar
  46. Pissarenko NF (1994) Radiation environment due to galactic and solar cosmic rays during manned mission to Mars in the periods between maximum and minimum solar activity cycles. Adv Space Res 14:771–778PubMedCrossRefGoogle Scholar
  47. Rashi-Elkeles S, Elkon R, Weizman N, Linhart C, Amariglio N, Sternberg G, Rechavi G, Barzilai A, Shamir R, Shiloh Y (2006) Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue. Oncogene 25:1584–1952PubMedCrossRefGoogle Scholar
  48. Rastegar N, Eckart P, Mertz M (2002) Radiation-induced cataract in astronauts and cosmonauts. Graefe Arch Clin Exp Ophthalmol 240:543–547Google Scholar
  49. Reddy MC, Vasquez KM (2005) Repair of genome destabilizing lesions. Radiat Res 164:345–356PubMedCrossRefGoogle Scholar
  50. Reeves GI, Ainsworth EJ (1995) Description of the chronic radiation syndrome in humans irradiated in the former Soviet Union. Radiat Res 142:242–243PubMedCrossRefGoogle Scholar
  51. Ron E (1998) Ionizing radiation and cancer risk: evidence from epidemiology. Radiat Res 150:S30–S41PubMedCrossRefGoogle Scholar
  52. Schmitt DA, Hatton JP, Emond C, Chaput D, Paris H, Levade T, Cazenave JP, Schaffar L (1996) The distribution of protein kinase C is altered in microgravity. FASEB J 10:1627–1634PubMedGoogle Scholar
  53. Shea MA, Smart DF (1994) Significant proton events of solar cycle 22 and a comparison with events of previous solar cycles. Adv Space Res 14:631–638PubMedCrossRefGoogle Scholar
  54. Shea MA, Smart DF (1998) Space weather: the effects on operations in space. Adv Space Res 22:29–38CrossRefGoogle Scholar
  55. Simonsen LC, Wilson JW, Kim MH, Cucinotta FA (2000) Radiation exposure for human Mars exploration. Health Phys 79:515–525PubMedCrossRefGoogle Scholar
  56. Smart DF, Shea MA (2002) A review of solar proton events during the 22nd solar cycle. Adv Space Res 30:1033–1044PubMedCrossRefGoogle Scholar
  57. Smart DF, Shea MA (2003) The local time dependence of the anisotropic solar cosmic ray flux. Adv Space Res 32:109–114PubMedCrossRefGoogle Scholar
  58. Smiraldo PG, Gruver AM, Osborn JC, Pittman DL (2005) Extensive chromosomal instability in Rad51d-deficient Mouse Cells. Cancer Res 65:2089–2096PubMedCrossRefGoogle Scholar
  59. Snyder AR, Morgan WF (2004) Gene expression profiling after irradiation: Clues to understanding acute and persistent responses? Cancer Metastasis Rev 23:259–268PubMedCrossRefGoogle Scholar
  60. Sonnenfeld G (1999) Space flight, microgravity, stress, and immune responses. Adv Space Res 23:1945–1953PubMedCrossRefGoogle Scholar
  61. Spjeldvik WN, Bourdarie S, Boscher D (2002) Towards multi-dimensional space weather modeling for energetic oxygen ions in the Earth’s inner magnetosphere: equilibrium configuration. Adv Space Res 30:2839–2842CrossRefGoogle Scholar
  62. Sundaresan A, Risin D, Pellis NR (2004) Modeled microgravity-induced protein kinase C isoform expression in human lymphocytes. J Appl Physiol 96:2028–2033PubMedCrossRefGoogle Scholar
  63. Testard I, Sabatier L (1999) Biological dosimetry for astronauts: a real challenge. Mutat Res 430:315–326PubMedGoogle Scholar
  64. Todd P, Pecaut MJ, Fleshner M (1999) Combined effects of space flight factors and radiation on humans. Mutat Res 430:211–219PubMedGoogle Scholar
  65. Townsend LW, Cucinotta FA, Wilson JW (1992) Interplanetary crew exposure estimates for galactic cosmic rays. Radiat Res 129:48–52PubMedCrossRefGoogle Scholar
  66. Virtanen A (2006) The use of particle accelerators for space projects. J Physics Conf Ser 41:101–114CrossRefGoogle Scholar
  67. Weiss JF, Landauer MR (2003) Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology 189:1–20PubMedCrossRefGoogle Scholar
  68. Wilson JW, Townsend LW, Nealy JE, Chun SY, Hong BS, Buck WW, Lamkin SL, Ganapol BD, Khan F, Cucinotta FA (1989) BRYNTRN: a Baryon Transport model. NASA TP 2887. National Aeronautics and Space Administration PressGoogle Scholar
  69. Wilson JW, Cucinotta FA, Shinn JL, Simonsen LC, Dubey RR, Jordan WR, Jones TD, Chang CK, Kim MY (1999) Shielding from solar particle event exposures in deep space. Radiat Meas 30:361–382CrossRefGoogle Scholar
  70. Wood RD (1996) Repair in eukaryotes. Ann Rev Biochem 65:135–167PubMedCrossRefGoogle Scholar
  71. Wu B, Medvedovsky C, Worgul BV (1994) Non-subjective cataract analysis and its application in space radiation risk assessment. Adv Space Res 14:493–500PubMedCrossRefGoogle Scholar
  72. Zaider M (2001) The risk of leukemia from low doses of low-LET radiation. Math Comp Model 33:1307–1313CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.DLR, Institut für Luft-und RaumfahrtmedizinCologneGermany

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