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Naturwissenschaften

, Volume 92, Issue 7, pp 305–309 | Cite as

New symbiotic hypothesis on the origin of eukaryotic flagella

  • Jing Yan Li
  • Chuan Fen Wu
Review

Abstract

The origin of eukaryotic flagella has long been a mystery. Here we review the possibility that flagella sprouted evolutionarily from the eukaryotic cell proper seems very unlikely because it is hard to imagine what function and benefit in natural selection the flagella would have provided to the cells when they first emerged as simple buds. Lynn Margulis’ 1970 spirochete hypothesis, though popular still, has never been confirmed. Moreover, the absence of tubulin and axonemal dynein in the spirochetes and the incapability of the bacterial and eukaryotic membranes’ making a continuum now suggest that the hypothesis is outdated. Tubulin genes were recently identified in a new bacteria division, verrucomicrobia, and microtubules have also been found in one of these species, epixenosomes, the defensive ectosymbionts. On the basis of these data, we propose a new symbiotic hypothesis: that the mid-ancestor of eukaryotic cells obtained epixenosomelike verrucomicrobia as defensive ectosymbionts and the ectosymbionts later became endosymbiotic. They still, however, protruded from the surface of their host to play their role. Later, many genes were lost or incorporated into the host genome. Finally, the genome, the bacterial membrane, and the endosymbiotic vesicle membrane were totally lost, and fingerlike protrusions with microtubules formed. As the cells grew larger, the defensive function of the protrusions eventually weakened and then vanished. Some of the protrusions took on a new role in cell movement, which led them to evolve into flagella. The key step in this process was that the dynein obtained from the host evolved into axonemal dyneins, attaching onto the microtubules and forming motile axonemes. Our hypothesis is unproven, but it offers a possible explanation that is consistent with current scientific thought. We hope that our ideas will stimulate additional studies on the origin of eukaryotic flagella and on investigations of verrucomicrobia. Whether such studies confirm, refine, or replace our hypothesis, they should nevertheless further our understanding of the origin of eukaryotic cells.

Keywords

Verrucomicrobia Bacterial Plasma Membrane Cytoplasmic Dynein Tubulin Gene Cytoplasmic Microtubule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We are deeply grateful to Dr Malgosia Kloc for her comments on the manuscript and to Mr Wen Ke Li for his help in creating the figures. We thank Ms Gayle Nesom, Ms Kate Ó’Súilleabháin, and Mr David Galloway of the Department of Scientific Publications at The University of Texas M. D. Anderson Cancer Center for their editing help. We especially thank Dr James T. Staley for allowing us to diagram the phylogenetic tree

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Key Laboratory of Cellular and Molecular EvolutionKunming Institute of Zoology, Chinese Academy of SciencesKunmingPeople’s Republic of China
  2. 2.Department of Molecular GeneticsThe University of Texas M. D. Anderson Cancer CenterHoustonUSA

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