, Volume 92, Issue 6, pp 293–296 | Cite as

Hormetic protection of Drosophila melanogaster middle-aged male flies from heat stress by mildly stressing them at young age

  • Éric Le BourgEmail author
Short Communication


Previous studies have shown that exposing flies to hypergravity (3g or 5g) for the first 2 weeks of adult life slightly increases longevity of male flies and survival time at 37°C for both sexes, and delays an age-linked behavioral change. The present experiment tested whether the hypergravity could also protect flies from four successive deleterious non-lethal heat shocks at 4 and 5 weeks of age. Males that lived in hypergravity for the first 2 weeks of adult life lived slightly longer (ca. +15% or 1.2 day) after heat shocks (30 min or 45 min at 37°C) than flies that always lived at 1g, but this positive effect of hypergravity was not observed in females. Therefore, hypergravity exposure at young age can help the male flies recovering from a heat shock at older ages.


Heat Shock Caloric Restriction Ischemic Precondition Mild Stress Gravity Level 
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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Centre de Recherche sur la Cognition Animale, UMR CNRS 5169Université Paul-SabatierToulouse cedex 4France

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