, Volume 89, Issue 3, pp 120–124 | Cite as

Bioproduction strategies for rare hexose sugars

  • Ken Izumori
Short Communication


A new strategy for the bioproduction of all ketohexoses was developed using hexitols as intermediates. Biocatalysts used to employ the strategy were D-tagatose 3-epimerase, which epimerizes ketohexoses at the C-3 position, and oxidoreductases, which catalyze oxidation–reduction reactions between ketohexoses and the corresponding hexitols. Arranging all the ketohexoses and hexitols in a symmetric ring and connecting them with 20 biochemical reactions, I was able to construct a design for the bioproduction of all the rare ketohexoses. Various aldose isomerases transform ketohexoses into the corresponding aldohexoses, so the strategy is useful for the bioproduction of all the rare hexose sugars. Furthermore, the design revealed that there are four routes to the L-hexose world from the D-hexose one.


Galactitol Tagatose Lactitol Aldohexoses Ketohexoses 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Ken Izumori
    • 1
  1. 1.Department of Biochemistry and Food Science, Faculty of Agriculture, Kagawa University, Kagawa 761-0795, JapanJapan

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