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Beeinflussung des Mikrobioms durch Probiotika in der pädiatrischen Praxis

Sinn oder Unsinn?
  • C. U. Meyer
  • J. Klopp
  • R. L. Knoll
  • S. GehringEmail author
Leitthema
  • 103 Downloads

Zusammenfassung

Hintergrund und Fragestellung

Bahnbrechende Erkenntnisse bezüglich des humanen Mikrobioms und dessen Interaktion mit dem menschlichen Körper in Gesundheit und Krankheit werfen die Frage auf, ob und wie therapeutischer Einfluss auf dieses System genommen werden kann.

Material und Methoden

Überblick und Auswertung der für die Pädiatrie relevanten Fachpublikationen.

Ergebnisse

Der positive Nutzen von Probiotika auf den Verlauf oder die Prävention bestimmter Erkrankungen gilt als wahrscheinlich. Die Wirkung hängt jedoch von einer Vielzahl von Faktoren ab.

Schlussfolgerung

Probiotika stellen in vielen Fällen eine unbedenkliche, wenn auch nicht in allen Fällen erfolgversprechende Therapieoption dar. Fortschritte im Bereich der Mikrobiomforschung sowie ein besseres Verständnis der Interaktion einzelner Mikroorganismen und molekularer Wirkmechanismen werden die Qualität und die Indikation probiotischer Intervention zukünftig verbessern.

Schlüsselwörter

Sepsis Nekrotisierende Enterkolitis Formulanahrung Frühgeburtlichkeit Antibiotika 

Modulation of the microbiome by probiotics in pediatric practise

Sense or nonsense?

Abstract

Background and objective

Groundbreaking progress in the field of microbiome research, its role in diseases and its interactions with the human body to promote health have sparked an immense interest in the therapeutic possibilities of microbiome-modulating treatment.

Material and method

Review and analysis of the current scientific literature relevant for pediatrics.

Results

A benefit of probiotics in prevention or the course of several disease entities is likely. The impact is dependent on several influencing factors.

Conclusion

Probiotics constitute in many cases a harmless, even though not in all cases effective therapeutic option. Further improvements in the field of microbiome research and a better understanding of the interactions between different microorganisms and their molecular mechanism of action will yield improved application and increase the quality of probiotic interventions in the future.

Keywords

Sepsis Necrotizing enterocolitis Infant formula Premature birth Antibiotics 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

C.U. Meyer, J. Klopp, R.L. Knoll und S. Gehring geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  • C. U. Meyer
    • 1
  • J. Klopp
    • 1
  • R. L. Knoll
    • 1
  • S. Gehring
    • 1
    Email author
  1. 1.Zentrum für Kinder- und JugendmedizinUniversitätsmedizin, Johannes Gutenberg-UniversitätMainzDeutschland

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