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Hepatitis-C-Virusinfektion bei Kindern und Jugendlichen

Leitlinie der Deutschen Gesellschaft für Kinder- und Jugendmedizin e.V. und der Gesellschaft für Pädiatrische Gastroenterologie und Ernährung e. V.

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Literatur

  1. Schreier E, Höhne M (2001) Hepatitis C – Epidemiologie und Prävention. Bundesgesundheitsbl 44:7

    Article  Google Scholar 

  2. Gerner P, Wirth S, Wintermeyer P et al (2006) Prevalence of hepatitis C virus infection in children admitted to an urban hospital. J Infect 52:305–308

    Article  PubMed  Google Scholar 

  3. Bortolotti F, Iorio R, Resti M et al (2007) Epidemiological profile of 806 Italian children with hepatitis C virus infection over a 15-year period. J Hepatol 46:783–790

    Article  PubMed  Google Scholar 

  4. England K, Thorne C, Newell ML (2006) Vertically acquired paediatric coinfection with HIV and hepatitis C virus. Lancet Infect Dis 6:83–90

    Article  PubMed  Google Scholar 

  5. Davison SM, Mieli-Vergani G, Sira J, Kelly DA (2006) Perinatal hepatitis C virus infection: diagnosis and management. Arch Dis Child 91:781–785

    Article  CAS  PubMed  Google Scholar 

  6. Polywka S, Schroter M, Feucht HH et al (1999) Low risk of vertical transmission of hepatitis C virus by breast milk. Clin Infect Dis 29:1327–1329

    Article  CAS  PubMed  Google Scholar 

  7. Bortolotti F, Guido M, Zancan L, Gussetti N (2004) Long-term outcome of hepatitis C in children. Hepatology 39:1455

    Article  PubMed  Google Scholar 

  8. Broide E, Kimchi NA, Scapa E (2006) Chronic hepatitis C infection in children. Minerva Gastroenterol Dietol 52:187–193

    CAS  PubMed  Google Scholar 

  9. Goodman ZD, Makhlouf HR, Liu L et al (2008) Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial. Hepatology 47:836–843

    Article  PubMed  Google Scholar 

  10. Rerksuppaphol S, Hardikar W, Dore GJ (2004) Long-term outcome of vertically acquired and post-transfusion hepatitis C infection in children. J Gastroenterol Hepatol 19:1357–1362

    Article  PubMed  Google Scholar 

  11. Barshes NR, Udell IW, Lee TC et al (2006) The natural history of hepatitis C virus in pediatric liver transplant recipients. Liver Transpl 12:1119–1123

    Article  PubMed  Google Scholar 

  12. Bortolotti F, Iorio R, Nebbia G et al (2005) Interferon treatment in children with chronic hepatitis C: long-lasting remission in responders, and risk for disease progression in non-responders. Dig Liver Dis 37:336–341

    Article  CAS  PubMed  Google Scholar 

  13. Rumbo C, Fawaz RL, Emre SH et al (2006) Hepatitis C in children: a quaternary referral center perspective. J Pediatr Gastroenterol Nutr 43:209–216

    Article  PubMed  Google Scholar 

  14. Iorio R, Giannattasio A, Sepe A et al (2005) Chronic hepatitis C in childhood: an 18-year experience. Clin Infect Dis 41:1431–1437

    Article  PubMed  Google Scholar 

  15. Zuccotti GV, Torcoletti M, Salvini F et al (2004) Infants vertically infected with hepatitis C: a long term longitudinal follow-up. Pediatr Med Chir 26:50–52

    CAS  PubMed  Google Scholar 

  16. Slowik MK, Jhaveri R (2005) Hepatitis B and C viruses in infants and young children. Semin Pediatr Infect Dis 16:296–305

    Article  PubMed  Google Scholar 

  17. Wirth S, Pieper-Boustani H, Lang T et al (2005) Peginterferon alfa-2b plus ribavirin treatment in children and adolescents with chronic hepatitis C. Hepatology 41:1013–1018

    Article  CAS  PubMed  Google Scholar 

  18. Wirth S, Ribes-Koninckx C, Bortolotti F et al (2010) High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin. J Hepatol 52:501-507:501–507

    Google Scholar 

  19. Kelly D, Haber B, Gonzalez-Peralta RP et al (2008) Sustained virologic response to interferon alfa-2b plus ribavirin predicts long-term clearance of HCV in pediatric patients at 5 year follow-up. J Heaptol 48 [Suppl 2]:298–299

  20. Schwarz KB, Gonzalez-Peralta RP, Murray KF et al (2008) Peginterferon with or without ribavirin for chronic hepatitis C in children and adolescents: final results of the PEDS-C trial (abstract). Hepatology 48 [Suppl]:418A

  21. Figlerowicz M, Sluzewski W, Kowala-Piaskowska A, Mozer-Lisewska I (2004) Interferon alpha and ribavirin in the treatment of children with chronic hepatitis C. Eur J Pediatr 163:265–267

    Article  PubMed  Google Scholar 

  22. Gonzalez-Peralta RP, Kelly DA, Haber B et al (2005) Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokinetics. Hepatology 42:1010–1018

    Article  CAS  PubMed  Google Scholar 

  23. Kowala-Piaskowska A, Figlerowicz M, Mozer-Lisewska I, Sluzewski W (2005) Effects of treatment with pegylated interferon and ribavirin in children with chronic hepatitis C. Przegl Epidemiol 59:491–498

    PubMed  Google Scholar 

  24. Sluzewski W, Mozer-Lisewska I, Figlerowicz M et al (2005) Current trends and first clinical studies of therapy for chronic hepatitis C in children using pegylated interferon alpha and ribavirin. Przegl Epidemiol 59:595–599

    PubMed  Google Scholar 

  25. Wozniakowska-Gesicka T, Kups J, Wisniewska-Ligier M (2005) Sustained virological response in children with chronic Hepatitis C treated with interferon alpha and ribavirin. Przegl Lek 62:1405–1408

    PubMed  Google Scholar 

  26. Jara P, Hierro L, Vega A de la et al (2008) Efficacy and safety of peginterferon-alpha 2b and ribavirin combination therapy in children with chronic hepatitis C infection. Pediatr Infect Dis J 27:142–148

    PubMed  Google Scholar 

  27. Gehring S, Kullmer U, Koeppelmann S et al (2006) Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-alpha. World J Gastroenterol 12:5787–5792

    CAS  PubMed  Google Scholar 

  28. Kowala-Piaskowska A, Mozer-Lisewska I, Figlerowicz M, Sluzewski W (2007) Adverse effects during the treatment with pegylated interferon and ribavirin in children with chronic hepatitis C. Pharmacoepidemiol Drug Saf 16:1095–1103

    Article  CAS  PubMed  Google Scholar 

  29. Urganci N, Gulec S, Dogan S, Nuhoglu A (2006) Interferon and ribavirin treatment results of patients with HBV-HCV co-infection cured of childhood malignancies. Int J Infect Dis 10:453–457

    Article  CAS  PubMed  Google Scholar 

  30. Polywka S, Pembrey L, Tovo PA, Newell ML (2006) Accuracy of HCV-RNA PCR tests for diagnosis or exclusion of vertically acquired HCV infection. J Med Virol 78:305–310

    Article  CAS  PubMed  Google Scholar 

  31. England K, Pembrey L, Tovo PA, Newell ML (2005) Excluding hepatitis C virus (HCV) infection by serology in young infants of HCV-infected mothers. Acta Paediatr 94:444–450

    PubMed  Google Scholar 

  32. Bortolotti F, Verucchi G, Cammà C et al (2008) Italian observatory for HCV infection and hepatitis C in children. Long-term course of chronic hepatitis C in children: from viral clearance to end-stage liver disease. Gastroenterology 134:1900–1907

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Zentrum für Kinder- und Jugendmedizin, HELIOS Klinikum Wuppertal, Universität Witten/Herdecke, Heusnerstr. 40, 42283, Wuppertal, Deutschland

    S. Wirth

  2. Klinik für Kinder- und Jugendmedizin, St. Josef-Hospital Bochum, Bochum, Deutschland

    A. Schmidt-Choudhury

  3. Dr. von Haunersches Kinderspital, München, Deutschland

    P. Bufler

  4. Kinderklinik, Klinik 2, Universität Duisburg-Essen, Essen, Deutschland

    P. Gerner

  5. Abteilung für Allgemeine Pädiatrie und Neonatologie, Universitätsklinik für Kinder- und Jugendheilkunde Wien, Wien, Österreich

    W. Huber

  6. Klinik für Kinder- und Jugendmedizin, Klinikum Starnberg, Starnberg, Deutschland

    T. Lang

  7. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Regensburg, Regensburg, Deutschland

    M. Melter

  8. Zentrum Kinderheilkunde und Jugendmedizin, MHH Hannover, Hannover, Deutschland

    E. Pfister

Authors
  1. S. Wirth
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  2. A. Schmidt-Choudhury
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  3. P. Bufler
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  4. P. Gerner
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  5. W. Huber
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  6. T. Lang
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  7. M. Melter
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  8. E. Pfister
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Corresponding author

Correspondence to S. Wirth.

Additional information

______

Das vorliegende Konsensuspapier stellt einen Auszug aus folgender Leitlinie dar: Update der S3-Leitlinie Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus (HCV)-Infektion, AWMF-Register-Nr.: 021/012. Prophylaxis, Diagnosis and Therapy of Hepatitis C Virus (HCV) Infection: The German Guidelines on the Management of HCV Infection.

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Wirth, S., Schmidt-Choudhury, A., Bufler, P. et al. Hepatitis-C-Virusinfektion bei Kindern und Jugendlichen. Monatsschr Kinderheilkd 158, 593–596 (2010). https://doi.org/10.1007/s00112-010-2213-5

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  • DOI: https://doi.org/10.1007/s00112-010-2213-5

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