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Monatsschrift Kinderheilkunde

, Volume 151, Supplement 1, pp S17–S20 | Cite as

Allergien: Genetisch determiniertes Schicksal oder durch Umwelteinflüsse bestimmte Krankheit?

  • R. P. Lauener
Die Ontogenese der Immunkompetenz und Allergieentstehung
  • 138 Downloads

Zusammenfassung

Umweltfaktoren spielen bei der Entstehung von Allergien eine wichtige Rolle. So leiden Bauernkinder weniger häufig an Allergien als ihre Schulkameraden, die nicht auf einem Bauernhof aufwachsen. Je mehr Endotoxin im täglichen Umfeld der Kinder nachweisbar war, desto seltener litten sie an Allergien. In Untersuchungen mit Kindern aus dem gleichen Studienkollektiv konnte ein direkter Effekt von Mikroben in der Umgebung auf das angeborene Immunsystem der Bauernkinder nachgewiesen werden. Die immunologischen Mechanismen, die der Entstehung von Allergien entgegenwirken, sind noch nicht klar. Manches weist darauf hin, dass die Interaktion zwischen Umweltfaktoren, wie z. B. Mikroben, und Genen, die die Antwort des Wirts auf diese Umweltfaktoren beeinflussen, für die Entstehung von allergischen Krankheiten entscheidend ist.

Schlüsselwörter

Allergieentstehung Umweltfaktoren Immunologische Mechanismen Bauernhof 

Abstract

Environmental factors play an important role in the pathogenesis of allergies. Farm children suffer from far fewer allergies than their classmates who do not grow up on a farm. The higher the endotoxin concentration in the children's environment was, the less frequently the children were afflicted by allergies. In studies on children from the same trial group, a direct effect of environmental microbes on the immatureimmune system of farmer's children could be demonstrated. The immunological mechanisms that prevent allergies remain unclear. There are some indications that the interaction between environmental factors, e.g., microbes, and genes that influence the response of the host to these environmental factors is decisive in the development of allergic diseases.

Keywords

Development of allergy Environmental factors Immunological mechanisms Farm 

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Universitätskinderklinik Zürich
  2. 2.Universitätskinderklinik ZürichZürichSchweiz

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