Journal of Molecular Medicine

, Volume 77, Issue 9, pp 656–665

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling

  • Geert J.P.L. Kops
  • Boudewijn M.T. Burgering
Review

Abstract.

The proto-oncogene protein kinase B (PKB), also known as c-Akt, is a central player in a signaling pathway of which many components have been linked to tumorigenesis. Active forms of PKB as well as of its upstream activator phosphatidylinositol 3-kinase (PI3K) have been found to be responsible for the transforming activities of certain viruses, and the negative regulator of this pathway, PTEN, is a tumor suppressor. The identification of particular downstream targets of PKB has provided us with new insights into the possible mechanism of PI3K/PKB-mediated tumorigenicity. Recently a subfamily of Forkhead transcription factors was identified as additional targets for PI3K/PKB signaling. This review discusses the studies that have led to this conclusion and the possible implications of this finding for our understanding of how PI3K/PKB activity could lead to oncogenesis.

Proto-oncogene Protein kinase B Transcription Forkheads Tumor suppression 

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Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • Geert J.P.L. Kops
    • 1
  • Boudewijn M.T. Burgering
    • 1
  1. 1.Laboratory for Physiological Chemistry and Center for Biomedical Genetics, University of Utrecht, Universiteitsweg 100, 3584 CG UtrechtThe Netherlands

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