Journal of Molecular Medicine

, Volume 79, Issue 7, pp 390–398 | Cite as

Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcification

  • Darrell L. Ellsworth
  • Lawrence F. Bielak
  • Stephen T. Turner
  • Patrick F. Sheedy
  • Eric Boerwinkle
  • Patricia A. Peyser
Original Article

Abstract

Development and progression of atherosclerosis involves recruitment and binding of circulating leukocytes to areas of inflammation within the vascular endothelium mediated by a diverse array of cellular adhesion molecules. A polymorphism in the endothelial-leukocyte adhesion molecule 1 (E-selectin) gene has been implicated in early-onset, angiographically defined, severe atherosclerotic disease because it profoundly affects ligand recognition and binding specificity, resulting in a significant increase in cellular adhesion. Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40–88 years and 314 asymptomatic men aged 30–80 years from the Epidemiology of Coronary Artery Calcification Study. The E-selectin polymorphism was not associated with presence of CAC in men of any age or in women over age 50. In women 50 years of age or younger the E-selectin polymorphism was significantly associated with presence of CAC after adjustment for age, body mass index, systolic blood pressure, ratio of total cholesterol to high-density lipoprotein cholesterol, and smoking. The significant association between E-selectin and CAC in women 50 years of age or younger may suggest that the 128R allele is a risk factor for coronary atherosclerosis in younger asymptomatic women, who typically have lower levels of traditional risk factors and reduced adhesion molecule expression due to the presence of higher levels of endogenous hormones.

Atherosclerosis (coronary) Calcium Cellular adhesion molecules Computed tomography Genetics Heart disease 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Darrell L. Ellsworth
    • 1
  • Lawrence F. Bielak
    • 2
  • Stephen T. Turner
    • 3
  • Patrick F. Sheedy
    • 4
  • Eric Boerwinkle
    • 5
  • Patricia A. Peyser
    • 2
  1. 1.Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive MSC 7934, Bethesda, MD 20892-7934USA
  2. 2.Department of Epidemiology, University of Michigan, 109 Observatory, Ann Arbor, MI 48109USA
  3. 3.Division of Hypertension and Department of Internal Medicine, Mayo Clinic, Rochester, MNUSA
  4. 4.Department of Diagnostic Radiology, Mayo Clinic, Rochester, MNUSA
  5. 5.Human Genetics Center, University of Texas Health Science Center, Houston, TXUSA

Personalised recommendations