Journal of Molecular Medicine

, Volume 77, Issue 5, pp 427–436

Carbohydrate/peptide mimics: effect on MUC1 cancer immunotherapy

  • V. Apostolopoulos
  • M. S. Sandrin
  • I. F. C. McKenzie
Review

DOI: 10.1007/s001090050373

Cite this article as:
Apostolopoulos, V., Sandrin, M. & McKenzie, I. J Mol Med (1999) 77: 427. doi:10.1007/s001090050373

Abstract

 Recent clinical studies with mannan mucin immunotherapeutic agents indicate that patients produce predominantly antibody responses while mice produce a high cytotoxic T lymphocyte response. In studying the reason for the ’immune deviation’ occurring in mice to humans from cellular to antibody responses, it has been found that natural anti-Galα(1,3)Gal antibodies, present in all humans, react with the mucin component of the agent, providing an example of a carbohydrate-peptide mimic. The immune deviation can be overcome by in vitro sensitization of antigen-presenting cells in the absence of anti-Gal antibodies – at least in mice. The review examines the background of these observations and discusses other peptide carbohydrate mimics and immune deviation

Key words Immune deviation Mimics Galactoseα(1 3)galactose MUC1 Immunotherapy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • V. Apostolopoulos
    • 1
  • M. S. Sandrin
    • 1
  • I. F. C. McKenzie
    • 1
  1. 1.Austin Research Institute, Studley Road, Heidelberg, 3084 Victoria, Australia e-mail: i.mckenzie@ari.unimelb.edu.au Tel.: +613-92870666, Fax: +613-92870601AU

Personalised recommendations