Journal of Molecular Medicine

, Volume 74, Issue 10, pp 589–607

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

  • A. J. Whitmarsh
  • R. J. Davis

DOI: 10.1007/s001090050063

Cite this article as:
Whitmarsh, A. & Davis, R. J Mol Med (1996) 74: 589. doi:10.1007/s001090050063


 Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that are activated by dual phosphorylation on threonine and tyrosine residues in response to a wide array of extracellular stimuli. Three distinct groups of MAP kinases have been identified in mammalian cells [extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38]. These MAP kinases are mediators of signal transduction from the cell surface to the nucleus. One nuclear target of these MAP kinase signaling pathways is the transcription factor AP-1. MAP kinases regulate AP-1 transcriptional activity by multiple mechanisms. Here we review recent progress towards understanding AP-1 regulation by the ERK, JNK, and p38 MAP kinase signal transduction pathways.

Key words Signal transduction Mitogen-activated protein kinase AP-1 c-Fos c-Jun 

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • A. J. Whitmarsh
    • 1
  • R. J. Davis
    • 1
  1. 1.Howard Hughes Medical Institute, and Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USAUS

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