Journal of Molecular Medicine

, Volume 78, Issue 10, pp 575–579

Vitamin D receptor gene polymorphism is associated with serum total and ionized calcium concentration

  • Yukiko Nakano
  • Tetsuya Oshima
  • Shota Sasaki
  • Kazuko Yamaoka
  • Toshiyuki Matsumoto
  • Hidekazu Hirao
  • Ryoji Ozono
  • Hideo Matsuura
  • Goro Kajiyama
  • Masayuki Kambe
Original Article

Abstract

Restriction fragment length polymorphisms of the vitamin D receptor gene have recently been reported to be associated with changes in bone mineral density. Alterations in systemic calcium balance and Ca-regulating hormones such as 1,25(OH)2 vitamin D3 and parathyroid hormone have been demonstrated in essential hypertension. We investigated the relationship between polymorphisms of the vitamin D receptor gene and systemic Ca metabolism in patients with essential hypertension and in normotensives. We compared 147 subjects with essential hypertension and 100 normotensive control subjects. The genotype distribution and derived allele frequencies for the vitamin D receptor gene were similar in the two groups (genotype bb/Bb/BB and allele B/b: 60.1/32.6/7.2 and 0.24/0.76 in hypertensives vs. 56.0/36.0/8.0 and 0.26/0.74 in normotensive subjects). Serum concentrations of total Ca in the bb, Bb, and BB groups were, respectively, 4.5±0.3 vs. 4.5±0.4 vs. 4.4±0.5 mmol/l in normotensives and 4.6±0.3 vs. 4.6±0.4 vs. 4.4±0.5 mmol/l in hypertensives. Ionized Ca levels were 1.17±0.04 vs. 1.16±0.04 vs. 1.15±0.04 mmol/l in normotensives and 1.16±0.04 vs. 1.16±0.04 vs. 1.14±0.05 mmol/l in hypertensives, respectively. These results indicate that the BB genotype of the vitamin D receptor gene is associated with lower serum Ca levels but is not a useful predictive marker for the development of essential hypertension in Japanese subjects.

Vitamin D receptor gene Polymorphism Calcium 1,25(OH)2 vitamin D3 Hypertension 

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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Yukiko Nakano
    • 1
  • Tetsuya Oshima
    • 1
  • Shota Sasaki
    • 1
  • Kazuko Yamaoka
    • 1
  • Toshiyuki Matsumoto
    • 1
  • Hidekazu Hirao
    • 1
  • Ryoji Ozono
    • 1
  • Hideo Matsuura
    • 1
  • Goro Kajiyama
    • 1
  • Masayuki Kambe
    • 1
  1. 1.Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734Japan

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