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Journal of Molecular Medicine

, Volume 97, Issue 4, pp 451–462 | Cite as

Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure

  • You Wu
  • Yong-Ming YaoEmail author
  • Zhong-Qiu LuEmail author
Review
  • 433 Downloads

Abstract

Sepsis is a dysregulated response to severe infection characterized by life-threatening organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the central characteristic of sepsis and is associated with poor outcome of septic patients. Ultrastructural damage to the mitochondria and mitochondrial dysfunction are reported in sepsis. Mitochondrial dysfunction with subsequent ATP deficiency, excessive reactive oxygen species (ROS) release, and cytochrome c release are all considered to contribute to organ failure. Consistent mitochondrial dysfunction leads to reduced mitochondrial quality control capacity, which eliminates dysfunctional and superfluous mitochondria to maintain mitochondrial homeostasis. Mitochondrial quality is controlled through a series of processes including mitochondrial biogenesis, mitochondrial dynamics, mitophagy, and transport processes. Several studies have indicated that multiple organ failure is ameliorated by restoring mitochondrial quality control mechanisms and is further amplified by defective quality control mechanisms. This review will focus on advances concerning potential mechanisms in regulating mitochondrial quality control and impacts of mitochondrial quality control on the progression of sepsis.

Keywords

Sepsis Mitochondrial dysfunction Mitochondrial biogenesis Mitophagy Mitochondrial dynamics 

Notes

Funding information

This work was supported, in part, by grants from the National Natural Science Foundation (grant numbers 81571937 and 81772112).

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Emergency DepartmentThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouPeople’s Republic of China
  2. 2.Wenzhou Municipal Key Laboratory of Emergency, Critical Care and Disaster MedicineThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouPeople’s Republic of China
  3. 3.Trauma Research CenterFirst Hospital Affiliated to the Chinese PLA General HospitalBeijingPeople’s Republic of China
  4. 4.College of NursingWenzhou Medical UniversityWenzhouPeople’s Republic of China

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