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Approaches to therapeutic angiogenesis for ischemic heart disease

  • Takerra Johnson
  • Lina Zhao
  • Gygeria Manuel
  • Herman Taylor
  • Dong Liu
Review
  • 190 Downloads

Abstract

Ischemic heart disease (IHD) is caused by the narrowing of arteries that work to provide blood, nutrients, and oxygen to the myocardial tissue. The worldwide epidemic of IHD urgently requires innovative treatments despite the significant advances in medical, interventional, and surgical therapies for this disease. Angiogenesis is a physiological and pathophysiological process that initiates vascular growth from pre-existing blood vessels in response to a lack of oxygen. This process occurs naturally over time and has encouraged researchers and clinicians to investigate the outcomes of accelerating or enhancing this angiogenic response as an alternative IHD therapy. Therapeutic angiogenesis has been shown to revascularize ischemic heart tissue, reduce the progression of tissue infarction, and evade the need for invasive surgical procedures or tissue/organ transplants. Several approaches, including the use of proteins, genes, stem/progenitor cells, and various combinations, have been employed to promote angiogenesis. While clinical trials for these approaches are ongoing, microvesicles and exosomes have recently been investigated as a cell-free approach to stimulate angiogenesis and may circumvent limitations of using viable cells. This review summarizes the approaches to accomplish therapeutic angiogenesis for IHD by highlighting the advances and challenges that addresses the applicability of a potential pro-angiogenic medicine.

Keywords

Angiogenesis Ischemic heart disease Myocardial infarction 

Abbreviations

AMI

Acute myocardial infarction

ASC

Adipose-derived stem cell

BM

Bone marrow

CABG

Coronary artery bypass grafting

CCSAC

Canadian Cardiovascular Society Angina Classification

EC

Endothelial cells

EDV

End diastolic volume

EMT

Epithelial to mesenchymal transition

FGF

Fibroblast growth factor

EPC

Endothelial progenitor cell

EV

Extracellular vesicles

HIF-1α

Hypoxia inducible factor-1α

IC

Intracoronary infusion

IHD

Schemic heart disease

IM

Intramyocardial injection

IPSC

Induced pluripotent stem cell

IVPC

Induced vascular progenitor cell

LVEF

Left ventricle ejection fraction

LVESV

Left ventricle end systolic volume

MSC

Mesenchymal stem cells

MV

Microvesicle

PCI

Percutaneous injection

PlGF

Placental-derived growth factor

PDGF

Platelet-derived growth factor

SDF1

Stromal cell-derived factor 1

TV

tail vein

VEGF

Vascular endothelial growth factor

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Morehouse School of MedicineCardiovascular Research InstituteAtlantaUSA
  2. 2.Department of BiochemistrySpelman CollegeAtlantaUSA

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