Journal of Molecular Medicine

, Volume 97, Issue 1, pp 19–24 | Cite as

Emerging role of circadian rhythm in bone remodeling

  • Qian-Yuan Wu
  • Jian Wang
  • Xiao Tong
  • Jie Chen
  • Bei Wang
  • Zong-Ning Miao
  • Xia Li
  • Jun-Xing Ye
  • Feng-Lai YuanEmail author


The 24-h rhythm of behavioral and physiological processes is a typical biological phenomenon regulated by a group of circadian rhythm genes. Dysfunction of the circadian rhythm can cause a wide range of problems, such as cancer and metabolic diseases. In recent decades, increased understanding of the roles of circadian rhythm genes in the bone remodeling process have been documented, including osteoblastic bone formation, osteoclastic bone resorption, and osteoblast/osteoclast communication. A timely review of the current findings may help to facilitate the new field of circadian rhythmic bone remodeling research. Targeted pharmacological modulation of circadian rhythm genes is a possible therapeutic approach through which to overcome bone remodeling problems in the future.


Osteoblast Osteoclast Circadian rhythm Bone remodeling 


Funding information

This study was supported by the Natural Science Foundation of China (81270011; 81472125), the Natural Science Foundation of Jiangsu Province (Grant BK20151114), Foundation of Traditional Chinese Medicine of Jiangsu Province (YB201578), and Fundamental Research Funds for Medical Innovation Center of Health and Family Planning Commission of Wuxi (CXTD006).

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Qian-Yuan Wu
    • 1
  • Jian Wang
    • 1
  • Xiao Tong
    • 1
  • Jie Chen
    • 1
  • Bei Wang
    • 2
  • Zong-Ning Miao
    • 2
  • Xia Li
    • 2
  • Jun-Xing Ye
    • 2
  • Feng-Lai Yuan
    • 2
    Email author
  1. 1.Department of PediatricsThe Third Hospital Affiliated to Nantong UniversityWuxiChina
  2. 2.Department of Orthopaedics and Central LaboratoryThe Third Hospital Affiliated to Nantong UniversityWuxiChina

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