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Emerging role of circadian rhythm in bone remodeling

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Abstract

The 24-h rhythm of behavioral and physiological processes is a typical biological phenomenon regulated by a group of circadian rhythm genes. Dysfunction of the circadian rhythm can cause a wide range of problems, such as cancer and metabolic diseases. In recent decades, increased understanding of the roles of circadian rhythm genes in the bone remodeling process have been documented, including osteoblastic bone formation, osteoclastic bone resorption, and osteoblast/osteoclast communication. A timely review of the current findings may help to facilitate the new field of circadian rhythmic bone remodeling research. Targeted pharmacological modulation of circadian rhythm genes is a possible therapeutic approach through which to overcome bone remodeling problems in the future.

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Funding

This study was supported by the Natural Science Foundation of China (81270011; 81472125), the Natural Science Foundation of Jiangsu Province (Grant BK20151114), Foundation of Traditional Chinese Medicine of Jiangsu Province (YB201578), and Fundamental Research Funds for Medical Innovation Center of Health and Family Planning Commission of Wuxi (CXTD006).

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Authors and Affiliations

  1. Department of Pediatrics, The Third Hospital Affiliated to Nantong University, Wuxi, 214041, Jiangsu, China

    Qian-Yuan Wu, Jian Wang, Xiao Tong & Jie Chen

  2. Department of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, 214041, Jiangsu, China

    Bei Wang, Zong-Ning Miao, Xia Li, Jun-Xing Ye & Feng-Lai Yuan

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  1. Qian-Yuan Wu
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  2. Jian Wang
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  3. Xiao Tong
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  4. Jie Chen
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  5. Bei Wang
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  6. Zong-Ning Miao
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  7. Xia Li
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  9. Feng-Lai Yuan
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Correspondence to Feng-Lai Yuan.

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Wu, QY., Wang, J., Tong, X. et al. Emerging role of circadian rhythm in bone remodeling. J Mol Med 97, 19–24 (2019). https://doi.org/10.1007/s00109-018-1723-9

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  • DOI: https://doi.org/10.1007/s00109-018-1723-9

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