Journal of Molecular Medicine

, Volume 95, Issue 6, pp 575–588 | Cite as

The expansive role of oxylipins on platelet biology

  • Jennifer Yeung
  • Megan Hawley
  • Michael HolinstatEmail author


In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) from polyunsaturated fatty acids (PUFAs) which exhibit pro- or anti-thrombotic activity. Over the years, novel oxylipins generated from the interplay of theoxygenase activity in various cells, such as the specialized pro-resolving mediators (SPMs), have been identified and investigated in inflammatory disease models. Although platelets have been implicated in inflammation, the role and mechanism of these SPMs produced from immune cells on platelet function are still unclear. This review highlights the burgeoning classes of oxylipins that have been found to regulate platelet function; however, their mechanism of action still remains to be elucidated.


Lipoxygenase Cyclooxygenase Oxygenases Eicosanoids Prostaglandins Thrombosis 


Compliance with ethical standards

Sources of funding

This work was supported in part, by the National Institutes of Health Office of Dietary Supplement, R01 GM105671 (MH), R01 HL114405 (MH), and F31 HL129481 (JY).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of MichiganAnn ArborUSA
  2. 2.Department of Internal Medicine, Division of Cardiovascular MedicineUniversity of MichiganAnn ArborUSA

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