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Journal of Molecular Medicine

, Volume 94, Issue 1, pp 5–11 | Cite as

Molecules in medicine mini-review: isoforms of PI3K in biology and disease

  • Bart VanhaesebroeckEmail author
  • Maria A. Whitehead
  • Roberto Piñeiro
Molecules in Medicine

Abstract

The PI3K lipid kinases are involved in signal transduction and intracellular vesicular traffic, endowing these enzymes with multiple cellular functions and important roles in normal physiology and disease. In this mini-review, we aim to distill from the vast PI3K literature the key relevant concepts for successful targeting of this pathway in disease. Of the eight isoforms of PI3K, the class I PI3Ks have been implicated in the aetiology and maintenance of various diseases, most prominently cancer, overgrowth syndromes, inflammation and autoimmunity, with emerging potential roles in metabolic and cardiovascular disorders. The development of class I PI3K inhibitors, mainly for use in cancer and inflammation, is a very active area of drug development. In 2014, an inhibitor of the p110δ isoform of PI3K was approved for the treatment of specific human B cell malignancies. The key therapeutic indications of targeting each class I PI3K isoform are summarized and discussed.

Keywords

PI3K Signalling Vesicular traffic Cancer Overgrowth syndrome Immunity Inflammation Autoimmunity Diabetes Obesity Metabolic syndrome Pharmacological inhibitor 

Notes

Acknowledgments

Work in the laboratory of B.V. was supported by Cancer Research UK [C23338/A15965], the UK Biotechnology and Biological Sciences Research Council [BB/I007806/1], the Ludwig Institute for Cancer Research and the National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre.

The authors apologize to those authors whose work could not be cited due to space constraints.

Compliance with ethical standards

Competing interests

BV is a consultant to Karus Therapeutics (Oxford, UK).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Bart Vanhaesebroeck
    • 1
    Email author
  • Maria A. Whitehead
    • 1
  • Roberto Piñeiro
    • 1
  1. 1.UCL Cancer InstituteUniversity College LondonLondonUK

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