Journal of Molecular Medicine

, Volume 92, Issue 9, pp 913–924

Molecular and cellular basis of scleroderma

  • Beate Eckes
  • Pia Moinzadeh
  • Gerhard Sengle
  • Nico Hunzelmann
  • Thomas Krieg
Review

Abstract

Systemic sclerosis (scleroderma) is a chronic inflammatory disease that leads to fibrosis of the skin and involved internal organs. No efficient therapy is currently available. This review summarizes recent progress made in basic as well as clinical science and concludes with a concept that therapy targeting fibrosis in scleroderma needs to take into account the global microenvironment in the skin with its diverse cellular players interacting with a complex extracellular matrix environment and matrix-associated growth factors.

Keywords

Systemic sclerosis Scleroderma Extracellular microenvironment Pathophysiology Signaling 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Beate Eckes
    • 1
  • Pia Moinzadeh
    • 1
  • Gerhard Sengle
    • 2
    • 3
  • Nico Hunzelmann
    • 1
  • Thomas Krieg
    • 1
    • 3
    • 4
  1. 1.Department of DermatologyUniversity of CologneCologneGermany
  2. 2.Center for BiochemistryUniversity of CologneCologneGermany
  3. 3.Center for Molecular Medicine Cologne (CMMC)University of CologneCologneGermany
  4. 4.Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)University of CologneCologneGermany

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