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Journal of Molecular Medicine

, Volume 91, Issue 7, pp 803–809 | Cite as

Role of dynamin 2 in the disassembly of focal adhesions

  • Laura Briñas
  • Stéphane Vassilopoulos
  • Gisèle Bonne
  • Pascale Guicheney
  • Marc BitounEmail author
Review

Abstract

Dynamin 2 (DNM2) is involved in endocytosis and intracellular membrane trafficking through its function in vesicle formation from distinct membrane compartments. During the last decade, several studies pointed out an important role of DNM2-dependent trafficking in turnover of focal adhesions which represent a physical link between the extracellular matrix and the intracellular actin cytoskeleton, and a platform for several signalling pathways. Here, we review the involvement of DNM2 in structural and functional aspects of the focal adhesion sites. Mutations in the DNM2 gene cause two hereditary neuromuscular disorders: dominant centronuclear myopathy and Charcot–Marie–Tooth peripheral neuropathy. Potential impairment of focal adhesions as a pathophysiological hypothesis in DNM2-related human diseases is discussed.

Keywords

Dynamin 2 Focal adhesion Endocytosis Focal adhesion disassembly 

Notes

Acknowledgments

This work was supported by the Institut National de la Santé et de la Recherche Médicale, the Association Institut de Myologie (AIM), the Université Pierre et Marie Curie-Paris6 and the Centre National de la Recherche Scientifique. LB is recipient of an AIM fellowship.

Conflict of interest

There is no conflict of interest to disclose.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Laura Briñas
    • 1
    • 2
    • 3
    • 4
  • Stéphane Vassilopoulos
    • 1
    • 2
    • 3
    • 4
  • Gisèle Bonne
    • 1
    • 2
    • 3
    • 4
    • 5
  • Pascale Guicheney
    • 6
  • Marc Bitoun
    • 1
    • 2
    • 3
    • 4
    Email author
  1. 1.Université Pierre et Marie Curie-Paris 6, UM76ParisFrance
  2. 2.Inserm, U974ParisFrance
  3. 3.CNRS, UMR 7215ParisFrance
  4. 4.Institut de MyologieParisFrance
  5. 5.Service de Biochimie Métabolique, U.F. Cardiogénétique et Myogénétique, Groupe Hospitalier Pitié-SalpêtrièreAP-HPParisFrance
  6. 6.Inserm, U956ParisFrance

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