Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations
- 369 Downloads
We investigated the effect of 24 obesity-predisposing single nucleotide polymorphisms (SNPs), separately and in combination, on snacking behavior in three European populations. The 24 SNPs were genotyped in 7,502 subjects (1,868 snackers and 5,634 non-snackers). We tested the hypothesis that obesity risk variants or a genetic risk score increases snacking using a logistic regression adjusted for sex, age, and body mass index. The obesity genetic risk score was not associated with snacking (odds ratio (OR) = 1.00 [0.98–1.02], P value = 0.48). The obesity risk variants of two SNPs (rs925946 and rs7498665) close to the BDNF and SH2B1 genes showed nominal evidence of association with increased snacking (OR = 1.09 [1.01–1.17], P value = 0.0348 and OR = 1.11 [1.04–1.19], P value = 0.00703, respectively) but did not survive Bonferroni corrections for multiple testing. The associations of rs925946 and rs7498665 obesity risk variants with increased BMI (β = 0.180 [0.022–0.339], P value = 0.0258 and β = 0.166 [0.019–0.313], P value = 0.0271, respectively) were slightly attenuated after adjusting for snacking (β = 0.151 [−0.006 to 0.309], P value = 0.0591 and β = 0.152 [0.006–0.297], P value = 0.0413). Our data suggest that genetic predisposition to obesity does not significantly contribute to snacking behavior. The nominal associations of rs925946 and rs7498665 obesity risk variants near the BDNF and SH2B1 genes with increased snacking deserve further investigation.
KeywordsObesity Genome-wide association Single nucleotide polymorphism Snacking behavior BDNF SH2B1
We thank all the participants in the studies. This work was supported by the “Agence National de la Recherche” and by the “EU-funded EUROCHIP FP7 consortium.” D.M. is funded by a Tier 2 Canada Research Chair.
Conflict of interest
The authors declare no conflict of interest.
- 1.Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN et al (2011) National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 377:557–567PubMedCrossRefGoogle Scholar
- 7.Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, van Vliet-Ostaptchouk JV, Wijmenga C, van der Schouw YT (2009) Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr 90:951–959PubMedCrossRefGoogle Scholar
- 15.Rouskas K, Kouvatsi A, Paletas K, Papazoglou D, Tsapas A, Lobbens S, Vatin V, Durand E, Labrune Y, Delplanque J et al (2012) Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population. Obesity (Silver Spring) 20:389–395CrossRefGoogle Scholar
- 21.Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, Wihler C, Koliatsos VE, Tessarollo L (1999) Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A 96:15239–15244PubMedCrossRefGoogle Scholar
- 26.Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YC et al (2006) Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 55:3366–3371PubMedCrossRefGoogle Scholar
- 31.Monteleone P, Zanardini R, Tortorella A, Gennarelli M, Castaldo E, Canestrelli B, Maj M (2006) The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder. Neurosci Lett 406:133–137PubMedCrossRefGoogle Scholar