Journal of Molecular Medicine

, Volume 91, Issue 9, pp 1109–1115 | Cite as

Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations

  • Sébastien Robiou-du-Pont
  • Loïc Yengo
  • Emmanuel Vaillant
  • Stéphane Lobbens
  • Emmanuelle Durand
  • Fritz Horber
  • Olivier Lantieri
  • Michel Marre
  • Beverley Balkau
  • Philippe Froguel
  • David Meyre
Original Article

Abstract

We investigated the effect of 24 obesity-predisposing single nucleotide polymorphisms (SNPs), separately and in combination, on snacking behavior in three European populations. The 24 SNPs were genotyped in 7,502 subjects (1,868 snackers and 5,634 non-snackers). We tested the hypothesis that obesity risk variants or a genetic risk score increases snacking using a logistic regression adjusted for sex, age, and body mass index. The obesity genetic risk score was not associated with snacking (odds ratio (OR) = 1.00 [0.98–1.02], P value = 0.48). The obesity risk variants of two SNPs (rs925946 and rs7498665) close to the BDNF and SH2B1 genes showed nominal evidence of association with increased snacking (OR = 1.09 [1.01–1.17], P value = 0.0348 and OR = 1.11 [1.04–1.19], P value = 0.00703, respectively) but did not survive Bonferroni corrections for multiple testing. The associations of rs925946 and rs7498665 obesity risk variants with increased BMI (β = 0.180 [0.022–0.339], P value = 0.0258 and β = 0.166 [0.019–0.313], P value = 0.0271, respectively) were slightly attenuated after adjusting for snacking (β = 0.151 [−0.006 to 0.309], P value = 0.0591 and β = 0.152 [0.006–0.297], P value = 0.0413). Our data suggest that genetic predisposition to obesity does not significantly contribute to snacking behavior. The nominal associations of rs925946 and rs7498665 obesity risk variants near the BDNF and SH2B1 genes with increased snacking deserve further investigation.

Keywords

Obesity Genome-wide association Single nucleotide polymorphism Snacking behavior BDNF SH2B1 

Notes

Acknowledgments

We thank all the participants in the studies. This work was supported by the “Agence National de la Recherche” and by the “EU-funded EUROCHIP FP7 consortium.” D.M. is funded by a Tier 2 Canada Research Chair.

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

109_2013_1027_MOESM1_ESM.pdf (262 kb)
ESM 1 (PDF 261 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Sébastien Robiou-du-Pont
    • 1
    • 2
  • Loïc Yengo
    • 1
    • 2
  • Emmanuel Vaillant
    • 1
    • 2
  • Stéphane Lobbens
    • 1
    • 2
  • Emmanuelle Durand
    • 1
    • 2
  • Fritz Horber
    • 3
    • 4
  • Olivier Lantieri
    • 5
  • Michel Marre
    • 6
    • 7
  • Beverley Balkau
    • 8
    • 9
  • Philippe Froguel
    • 1
    • 2
    • 10
    • 12
  • David Meyre
    • 1
    • 2
    • 11
  1. 1.CNRS-UMR8199Lille Pasteur InstituteLilleFrance
  2. 2.Lille Nord de France UniversityLilleFrance
  3. 3.Department of Internal MedicineLiechtensteinisches LandesspitalVaduzLiechtenstein
  4. 4.Faculty of MedicineUniversity of BernBernSwitzerland
  5. 5.Institut inter Régional pour la SantéLa RicheFrance
  6. 6.Endocrinology–Diabetology–NutritionBichat-Claude Bernard HospitalParisFrance
  7. 7.University Denis Diderot ParisParisFrance
  8. 8.INSERM Centre de recherche en Epidémiologie et Santé des Populations U1018VillejuifFrance
  9. 9.University ParisVillejuifFrance
  10. 10.Genomic Medicine, Hammersmith HospitalImperial College LondonLondonUK
  11. 11.Department of Clinical Epidemiology and BiostatisticsMcMaster UniversityHamiltonCanada
  12. 12.Department of Genomics of Common Diseases, School of Public Health, Hammersmith HospitalImperial College LondonLondonUK

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