Journal of Molecular Medicine

, Volume 90, Issue 8, pp 865–875

Circulating microRNAs: novel biomarkers for cardiovascular diseases

Review

Abstract

MicroRNAs (miRNAs) are a novel class of small, non-coding, single-stranded RNAs that negatively regulate gene expression via translational inhibition or mRNA degradation followed by protein synthesis repression. Many miRNAs are expressed in a tissue- and/or cell-specific manner and their expression patterns are reflective of underlying patho-physiologic processes. miRNAs can be detected in serum or in plasma in a remarkably stable form, making them attractive biomarkers for human diseases. This review describes the progress of identifying circulating miRNAs as novel biomarkers for diverse cardiovascular diseases, including acute myocardial infarction, heart failure, coronary artery disease, diabetes, stroke, essential hypertension, and acute pulmonary embolism. In addition, the origin and function and the different strategies to identify circulating miRNAs as novel biomarkers for cardiovascular diseases are also discussed. Rarely has an opportunity arisen to advance such new biology for the diagnosis of cardiac diseases.

Keywords

MicroRNAs Plasma Serum Biomarker Cardiovascular diseases 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of Cardiology, Tongji HospitalTongji University School of MedicineShanghaiChina
  2. 2.Key Laboratory of Arrhythmias, Ministry of EducationChina (Shanghai East Hospital, Tongji University School of Medicine)ShanghaiChina
  3. 3.Department of RadiologyShanghai Third People’s Hospital, Shanghai Jiaotong University School of MedicineShanghaiChina
  4. 4.Cardiovascular InstituteBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  5. 5.Department of Psychiatry, Tongji HospitalTongji University School of MedicineShanghaiChina

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