Journal of Molecular Medicine

, Volume 89, Issue 6, pp 545–553

Recent developments in drug-eluting stents

Review

DOI: 10.1007/s00109-011-0729-3

Cite this article as:
Li, Y., Bhindi, R. & Khachigian, L.M. J Mol Med (2011) 89: 545. doi:10.1007/s00109-011-0729-3

Abstract

Percutaneous coronary intervention (PCI) is an important treatment approach in the management of symptomatic coronary artery disease (CAD). A significant development in PCI in the mid 1970s was balloon angioplasty, followed by bare-metal stents a decade later, and now, the widespread use of drug-eluting stents (DES). While PCI has conferred remarkable benefit to millions of CAD patients, restenosis, and late stent thrombosis associated with DES remain problematic, and improvements are keenly sought. This article reviews recent developments in DES.

Keywords

Drug-eluting stents Restenosis Late thrombosis Polymer Bioabsorbable stents Cardiovascular Cardiology Drug Delivery 

Abbreviations

BES

Biolimus-eluting stent

BMS

Bare-metal stent

BP

Biodegradable polymer

CABG

Coronary artery bypass grafting

CAD

Coronary artery disease

DES

Drug-eluting stents

EES

Everolimus-eluting stent

LLL

Late luminal loss

MACE

Major adverse cardiac events

MI

Myocardial infarction

MR

Moderate-release

OCT

Optical coherence tomography

PCI

Percutaneous coronary intervention

PES

Paclitaxel-eluting stent

PF

Polymer-free

PLLA

Poly-L-lactic acid

PP

Permanent polymer

RCT

Randomized controlled trial

SES

Sirolimus eluting stents

SR

Slow-release

TLR

Target lesion revascularization

TVR

Target vessel revascularization

ZES

Zotarolimus-eluting stent

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Centre for Vascular ResearchUniversity of New South WalesSydneyAustralia
  2. 2.Department of CardiologyRoyal North Shore HospitalSydneyAustralia

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