Journal of Molecular Medicine

, Volume 88, Issue 9, pp 873–880 | Cite as

Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors

Review

Abstract

Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.

Keywords

Dendritic cells Toll-like receptors CD14 Innate immunity Apoptosis 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Biotechnology and BioscienceUniversity of Milano-BicoccaMilanItaly

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