Journal of Molecular Medicine

, Volume 88, Issue 3, pp 235–239

Structural traces of past experience in the cerebral cortex



It is widely assumed that changes in the connections between neurons mediate the integration and storage of information in the brain and thereby underlie our ability to learn and remember. In particular, long-term memory is thought to rely on a structural reorganisation of neuronal circuits, but the proof for such a mechanism in the complex mammalian brain remains elusive. Recent advances in scientists' ability to follow structural dynamics of neuronal networks in the intact brain in vivo by means of 2-photon laser scanning microscopy has provided new insight into how information about new experiences might be stored in brain circuits.


Long-term memory Structural plasticity Experience-dependent plasticity Spine dynamics 2-photon Monocular deprivation 


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Neuroscience, Physiology and PharmacologyUniversity College LondonLondonUK

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