Journal of Molecular Medicine

, 87:1053

ATF3 transcription factor and its emerging roles in immunity and cancer

  • Matthew R. Thompson
  • Dakang Xu
  • Bryan R. G. Williams
Review

DOI: 10.1007/s00109-009-0520-x

Cite this article as:
Thompson, M.R., Xu, D. & Williams, B.R.G. J Mol Med (2009) 87: 1053. doi:10.1007/s00109-009-0520-x

Abstract

Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Advances made in understanding the immunobiology of Toll-like receptors have recently generated new momentum for the study of ATF3 in immunity. Moreover, the role of ATF3 in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.

Keywords

ATF3 Transcriptional regulation Immunity TLRs Oncogenesis Gene expression 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Matthew R. Thompson
    • 1
  • Dakang Xu
    • 1
  • Bryan R. G. Williams
    • 1
  1. 1.Monash Institute of Medical ResearchMonash UniversityMelbourneAustralia

Personalised recommendations