ATF3 transcription factor and its emerging roles in immunity and cancer
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Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Advances made in understanding the immunobiology of Toll-like receptors have recently generated new momentum for the study of ATF3 in immunity. Moreover, the role of ATF3 in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.
KeywordsATF3 Transcriptional regulation Immunity TLRs Oncogenesis Gene expression
This work was supported in part by a grant from the National Institutes of Health (P01 CA062220). MT was supported by a scholarship from the Australian Rotary Health Research Fund/Rotary District 9650 Bowelscan.
Conflict of interest statement
The authors declare that they have no conflict of interests.
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