Journal of Molecular Medicine

, Volume 87, Issue 9, pp 859–864

The interaction between ischemia–reperfusion and immune responses in the kidney

  • Hye Ryoun Jang
  • Gang Jee Ko
  • Barbara A. Wasowska
  • Hamid Rabb
Review

Abstract

Kidney ischemia–reperfusion injury (IRI) engages both the innate and adaptive immune responses. Cellular mediators of immunity, such as dendritic cells, neutrophils, macrophages, natural killer T, T, and B cells, contribute to the pathogenesis of renal injury after IRI. Postischemic kidneys express increased levels of adhesion molecules on endothelial cells and toll-like receptors on tubular epithelial cells. Soluble components of the immune system, such as complement activation proteins and cytokines, also participate in injury/repair of postischemic kidneys. Experimental studies on the immune response in kidney IRI have resulted in better understanding of the mechanisms underlying IRI and led to the discovery of novel therapeutic and diagnostic targets.

Keywords

Ischemia–reperfusion injury Immune response Inflammation 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Hye Ryoun Jang
    • 1
  • Gang Jee Ko
    • 1
  • Barbara A. Wasowska
    • 2
  • Hamid Rabb
    • 1
  1. 1.Nephrology Division, Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of PathologyJohns Hopkins University School of MedicineBaltimoreUSA

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