Journal of Molecular Medicine

, Volume 86, Issue 6, pp 697–703

AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia

  • Florian Herse
  • Anne Cathrine Staff
  • Lydia Hering
  • Dominik N. Müller
  • Friedrich C. Luft
  • Ralf Dechend
Review

DOI: 10.1007/s00109-008-0332-4

Cite this article as:
Herse, F., Staff, A.C., Hering, L. et al. J Mol Med (2008) 86: 697. doi:10.1007/s00109-008-0332-4

Abstract

Pre-eclampsia is a common, pregnancy-induced disorder, consisting of hypertension and proteinuria. The condition is one of the leading causes for maternal and perinatal morbidity and mortality. Nonetheless, the underlying molecular mechanisms remain unclear. Immunological mechanisms and the renin–angiotensin system have been implicated in the development of pre-eclampsia. Agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) have been identified in pre-eclamptic patients, unifying the two hypothesis. Evidence has also accumulated for the existence and importance of a local, utroplacental renin–angiotensin system. We summarize recent data emphasizing the pathophysiological role for the autoantibodies and the uteroplacental renin–angiotensin system.

Keywords

Pre-eclampsia Renin–angiotensin system Angiotensin receptor Hypertension 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Florian Herse
    • 1
  • Anne Cathrine Staff
    • 3
    • 4
  • Lydia Hering
    • 2
  • Dominik N. Müller
    • 2
  • Friedrich C. Luft
    • 1
    • 2
  • Ralf Dechend
    • 1
    • 2
    • 5
  1. 1.Medical Faculty of the CharitéFranz-Volhard ClinicBerlinGermany
  2. 2.Experimental and Clinical Research CenterMax-Delbrück-Center for Molecular MedicineBerlinGermany
  3. 3.Department of Obstetrics and GynaecologyUlleval University HospitalOsloNorway
  4. 4.Faculty of Medicine University of OsloOsloNorway
  5. 5.ChariteCampus-Buch and HELIOS Klinikum Berlin-BuchBerlinGermany

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