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Roles of PPARs on regulating myocardial energy and lipid homeostasis

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Abstract

Myocardial energy and lipid homeostasis is crucial for normal cardiac structure and function. Either shortage of energy or excessive lipid accumulation in the heart leads to cardiac disorders. Peroxisome proliferator-activated receptors (PPARα, -β/δ and -γ), members of the nuclear receptor transcription factor superfamily, play important roles in regulating lipid metabolic genes. All three PPAR subtypes are expressed in cardiomyocytes. PPARα has been shown to control transcriptional expression of key enzymes that are involved in fatty acid (FA) uptake and oxidation, triglyceride synthesis, mitochondrial respiration uncoupling, and glucose metabolism. Similarly, PPARβ/δ is a transcriptional regulator of FA uptake and oxidation, mitochondrial respiration uncoupling, and glucose metabolism. On the other hand, the role of PPARγ on transcriptional regulation of FA metabolism in the heart remains obscure. Therefore, both PPARα and PPARβ/δ are important transcriptional regulators of myocardial energy and lipid homeostasis. Moreover, it appears that the heart needs to have two PPAR subtypes with seemingly overlapping functions in maintaining myocardial lipid and energy homeostasis. Further studies on the potential distinctive roles of each PPAR subtype in the heart should provide new therapeutic targets for treating heart disease.

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Acknowledgments

This work was partially supported by grants from the NIH (S06GM08248 and 1R01HL085499-01), a scientist development award from the American Heart Association national center, and an institutional grant from NIH (NIH/NIHGMS S). We thank Kevin Yang for editing and proofreading the manuscript.

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  1. Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA, 30310, USA

    Qinglin Yang

  2. Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho Sakyo-ku, Kyoto, 606-8507, Japan

    Yuhao Li

  3. Faculty of Pharmacy A15, The University of Sydney, Sydney, NSW 2006, Australia

    Yuhao Li

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Correspondence to Qinglin Yang.

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Yang, Q., Li, Y. Roles of PPARs on regulating myocardial energy and lipid homeostasis. J Mol Med 85, 697–706 (2007). https://doi.org/10.1007/s00109-007-0170-9

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