Journal of Molecular Medicine

, Volume 83, Issue 7, pp 504–513

SUMO wrestling with type 1 diabetes

  • Manyu Li
  • Dehuang Guo
  • Carlos M. Isales
  • Decio L. Eizirik
  • Mark Atkinson
  • Jin-Xiong She
  • Cong-Yi Wang


Post-translational modification of proteins by phosphorylation, methylation, acetylation, or ubiquitylation represent central mechanisms through which various biological processes are regulated. Reversible covalent modification (i.e., sumoylation) of proteins by the small ubiquitin-like modifier (SUMO) has also emerged as an important mechanism contributing to the dynamic regulation of protein function. Sumoylation has been linked to the pathogenesis of a variety of disorders including Alzheimer’s disease (AD), Huntington’s disease (HD), and type 1 diabetes (T1D). Advances in our understanding of the role of sumoylation suggested a novel regulatory mechanism for the regulation of immune responsive gene expression. In this review, we first update recent advances in the field of sumoylation, then specifically evaluate its regulatory role in several key signaling pathways for immune response and discuss its possible implication in T1D pathogenesis.


SUMO Sumoylation Immune Regulation Transcription Autoimmunity 



Extracellular signal-regulated protein kinase


Janus kinase


c-Jun N-terminal kinase


Protein inhibitors of activated stats


Ran binding protein


Signal transducers and activators of transcription


Type 1 diabetes


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Manyu Li
    • 1
  • Dehuang Guo
    • 1
  • Carlos M. Isales
    • 2
  • Decio L. Eizirik
    • 3
  • Mark Atkinson
    • 4
  • Jin-Xiong She
    • 1
  • Cong-Yi Wang
    • 1
  1. 1.Center for Biotechnology and Genomic MedicineMedical College of GeorgiaAugustaUSA
  2. 2.Department of MedicineMedical College of GeorgiaAugustaUSA
  3. 3.Laboratory of Experimental MedicineUniversite Libre de BruxellesBrusselsBelgium
  4. 4.Department of Pathology, Immunology and Laboratory Medicine, College of MedicineUniversity of FloridaGainesvilleUSA

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