The sarcomeric Z-disc: a nodal point in signalling and disease

  • Derk Frank
  • Christian Kuhn
  • Hugo A. Katus
  • Norbert Frey
Review

Abstract

The perception of the Z-disc in striated muscle has undergone significant changes in the past decade. Traditionally, the Z-disc has been viewed as a passive constituent of the sarcomere, which is important only for the cross-linking of thin filaments and transmission of force generated by the myofilaments. The recent discovery of multiple novel molecular components, however, has shed light on an emerging role for the Z-disc in signal transduction in both cardiac and skeletal muscles. Strikingly, mutations in several Z-disc proteins have been shown to cause cardiomyopathies and/or muscular dystrophies. In addition, the elusive cardiac stretch receptor appears to localize to the Z-disc. Various signalling molecules have been shown to interact with Z-disc proteins, several of which shuttle between the Z-disc and other cellular compartments such as the nucleus, underlining the dynamic nature of Z-disc-dependent signalling. In this review, we provide a systematic view on the currently known Z-disc components and the functional significance of the Z-disc as an interface between biomechanical sensing and signalling in cardiac and skeletal muscle functions and diseases.

Keywords

Striated muscle Sarcomere Z-disc Heart Skeletal muscle Myopathy Cardiomyopathy Stretch receptor Muscle dystrophy Cell biology 

Notes

Acknowledgements

N.F. was supported by grants of the Deutsche Forschungsgemeinschaft (Fr1289/3-1) as well as the Bundesministerium für Forschung und Technologie (BMBF). D.F. was supported by the Young Investigator Award of the University of Heidelberg.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Derk Frank
    • 1
  • Christian Kuhn
    • 1
  • Hugo A. Katus
    • 1
  • Norbert Frey
    • 1
    • 2
  1. 1.Department of Internal Medicine IIIUniversity of HeidelbergHeidelbergGermany
  2. 2.Department of CardiologyUniversity of HeidelbergHeidelbergGermany

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