Journal of Molecular Medicine

, Volume 82, Issue 7, pp 434–448

Nuclear factor-κB: its role in health and disease

Review

DOI: 10.1007/s00109-004-0555-y

Cite this article as:
Kumar, A., Takada, Y., Boriek, A.M. et al. J Mol Med (2004) 82: 434. doi:10.1007/s00109-004-0555-y

Abstract

Nuclear factor-κB (NF-κB) is a major transcription factor that plays an essential role in several aspects of human health including the development of innate and adaptive immunity. The dysregulation of NF-κB is associated with many disease states such as AIDS, atherosclerosis, asthma, arthritis, cancer, diabetes, inflammatory bowel disease, muscular dystrophy, stroke, and viral infections. Recent evidence also suggests that the dysfunction of NF-κB is a major mediator of some human genetic disorders. Appropriate regulation and control of NF-κB activity, which can be achieved by gene modification or pharmacological strategies, would provide a potential approach for the management of NF-κB related human diseases. This review summarizes the current knowledge of the physiological and pathophysiological functions of NF-κB and its possible role as a target of therapeutic intervention

Keywords

Nuclear factor-κB Tumorigenesis Inflammation Immunity Therapy 

Abbreviations

aly

Alymphoplasia

HIV

Human immunodeficiency virus

IKK

IκB kinase

IL

Interleukin

MEKK

Mitogen-activated protein kinase kinase kinase

NEMO

Nuclear factor-κB essential modulator

NF-κB

Nuclear factor-κB

NIK

Nuclear factor-κB inducing kinase

TNF

Tumor necrosis factor

VCAM

Vascular cell adhesion molecules

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Department of MedicineBaylor College of MedicineHoustonUSA
  2. 2.Cytokine Research Laboratory, Department of BioimmunotherapyUniversity of Texas M. D. Anderson Cancer CenterHoustonUSA

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