Journal of Molecular Medicine

, Volume 82, Issue 4, pp 223–231

Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers



The Kapsosi’s sarcoma-associated herpesvirus, KSHV, is associated with cancers that have increased incidence in patients who are also HIV positive or who have undergone organ transplantation. It has recently been observed that β-catenin is overexpressed in two KSHV-associated cancers, Kaposi’s sarcoma and primary effusion lymphoma. Investigation of the underlying defect in β-catenin regulation revealed that the KSHV-encoded LANA protein stabilizes β-catenin by binding to the negative regulator GSK-3, causing a cell-cycle-dependent nuclear accumulation of GSK-3. Thus, redistribution of GSK-3 has been identified as yet another mechanism through which β-catenin can be dysregulated and contribute to human cancer.


Kaposi’s sarcoma-associated herpesvirus Latency-associated nuclear antigen GSK-3 β-Catenin Wnt pathway 



Adenomatous polyposis coli


Cyclin D1




Epstein-Barr virus


Frequently rearranged in advanced T cell lymphomas


Glycogen synthase kinase-3


Kaposi’s sarcoma


Kaposi’s sarcoma-associated herpesvirus


Latency-associated nuclear antigen


Lymphoid enhancer binding factor


Primary effusion lymphoma


T-cell transcription factor


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Viral Oncology Program, Sidney Kimmel Cancer CenterJohns Hopkins School of MedicineBaltimoreUSA
  2. 2.The Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins School of MedicineBaltimoreUSA

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