Journal of Molecular Medicine

, Volume 81, Issue 10, pp 613–626

Anti-inflammatory properties of lipid oxidation products

Review

DOI: 10.1007/s00109-003-0467-2

Cite this article as:
Bochkov, V.N. & Leitinger, N. J Mol Med (2003) 81: 613. doi:10.1007/s00109-003-0467-2

Abstract

Oxidative modification of lipids occurs during inflammatory processes and leads to the formation and accumulation of biologically active lipid oxidation products that induce specific cellular reactions. These reactions lead to a modulation of the inflammatory process and may determine the fate and outcome of the body's reaction in acute inflammation during host defense. The processes by which oxidized lipids may play an important role include resolution of inflammation involving apoptosis, chronic inflammatory processes, and innate and adaptive immune responses. The classical view of lipid oxidation products is that they can induce and propagate chronic inflammatory reactions. However, evidence is accumulating that cells and tissues respond towards these oxidatively formed stress signals also by activation of anti-inflammatory processes. These include defense strategies such as (a) induction of signaling pathways leading to the upregulation of anti-inflammatory genes, (b) inhibition of signaling pathways coupled to the expression of proinflammatory genes, and (c) preventing the interaction of proinflammatory bacterial products with host cells. This contribution summarizes recent findings on the anti-inflammatory action of oxidized lipoproteins and lipid oxidation products. We discuss confirmed and suggested mechanisms as well as the (patho)physiological significance of these findings.

Keywords

Anti-inflammatory processes Atherosclerosis Lipid oxidation products Oxidized lipoproteins Nuclear factor κB 

Abbreviations

AH

Acetylhydrolase

AP

Activator protein

COX

Cyclooxygenase

CRE

cAMP-response elements

CREB

cAMP-response element binding protein

Egr

Early growth response factor

HDL

High-density lipoprotein

HETE

Hydroxyeicosatetraenoic acid

HNE

Hydroxynonenal

HO

Heme oxygenase

HODE

Hydroxyoctadecadienoic acid

ICAM

Intercellular adhesion molecule

IFN

Interferon

IKK

IκB kinase

IL

Interleukin

LPS

Lipopolysaccharide

LXR

Liver X receptors

MCP

Monocyte chemotactic protein

MM-LDL

Minimally modified LDL

NF

Nuclear factor

NFAT

Nuclear factor activated T cells

OxLDL

Oxidized low-density lipoprotein

OxPAPC

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine

PAF

Platelet-activating factor

PG

Prostaglandin

PKA

Protein kinase A

POVPC

1-Palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine

PPAR

Peroxisome proliferator activated receptors

PPRE

Peroxisome proliferator activated receptor response element

ROS

Reactive oxygen species

STAT

Signal transducer and activator of transcription

TLR

Toll-like receptor

TNF

Tumor necrosis factor

VCAM

Vascular cell adhesion molecule

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Department of Vascular Biology and Thrombosis ResearchUniversity of ViennaViennaAustria

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