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Journal of Molecular Medicine

, Volume 80, Issue 9, pp 549–561 | Cite as

Cathelicidins, essential gene-encoded mammalian antibiotics

  • Mohamed Zaiou
  • Richard L. Gallo
Review

Abstract.

Cathelicidins are a class of gene-encoded antibiotics found exclusively in mammals. In vitro and in vivo studies indicate they are effector molecules of mammalian innate immunity that can provide a first line of defense against an array of micro-organisms. Additional functions are described for some members of this class of antimicrobial peptides including chemotactic activity, mitogenesis, and angiogenesis. Therefore these peptides are considered to be multifunctional effector molecules. This review discusses recent progress in cathelicidin research and the functional properties of cathelicidins. Current work in this field suggests that understanding this component of the mammalian innate immune system and related natural antibiotic peptides offer an opportunity for the development of novel therapeutic agents with which to battle the continued problem of antimicrobial resistance.

Antimicrobial peptides Cathelicidins Innate immunity Infection Wound healing 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Mohamed Zaiou
    • 1
  • Richard L. Gallo
    • 1
  1. 1.Department of Medicine (Dermatology), University of California, 3350 la Jolla Village Drive, Mail Code 151, San Diego, CA 92161 USAUSA

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