Der Internist

, Volume 55, Issue 8, pp 906–917

Therapie chronisch-entzündlicher Darmerkrankungen

Standards, Kontroversen und Perspektiven
Schwerpunkt

Zusammenfassung

Morbus Crohn und Colitis ulcerosa sind die häufigsten chronisch-entzündlichen Darmerkrankungen. Ihre Behandlung wird zunehmend komplex und gerade bei komplizierten Krankheitsverläufen auch individualisierter. Dieser Beitrag gibt einen umfassenden Überblick über die Verlaufsformen und die Standardtherapie beider Erkrankungen. Weiterhin wird auf aktuelle Kontroversen wie die frühe Immunsuppression und Immunmodulation, aber auch auf neue Therapieziele wie die Mukosaheilung eingegangen. Schließlich wird ein Ausblick auf zukünftige Therapieoptionen gegeben. Hier steht insbesondere Vedolizumab, ein Antikörper gegen das darmspezifische α4β7-Integrin, im Fokus.

Schlüsselwörter

Morbus Crohn Colitis ulcerosa Azathioprin Anti-TNF-Antikörper Vedolizumab 

Therapy of chronic inflammatory bowel diseases

Standards, controversies and perspectives

Abstract

Crohn’s disease and ulcerative colitis are the most common forms of chronic inflammatory bowel disease. The therapeutic algorithm is complex and individualized especially in complicated courses of the disease. This article gives a comprehensive overview on the typical courses of disease and the standard therapy of both diseases. Furthermore, ongoing controversies will be highlighted including early immunosuppression and immunomodulation as well as new therapeutic goals, such as mucosal healing. Finally, a perspective on future therapeutic options is given focusing especially on vedolizumab, the new antibody against the bowel-specific α4β7-integrin.

Keywords

Crohn’s disease Colitis, ulcerative Azathioprine Anti-tumor necrosis factor antibodies Vedolizumab 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Abteilung Innere Medizin 1Asklepios Klinik Nord, Standort HeidbergHamburgDeutschland
  2. 2.Medizinische Klinik I, Bereich Gastroenterologie und HepatologieUniversitätsklinik Schleswig-Holstein, Campus LübeckLübeckDeutschland
  3. 3.Gastroenterologie, Hepatologie und EndokrinologieRobert-Bosch-KrankenhausStuttgartDeutschland

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