Der Internist

, 50:1290 | Cite as

Sorafenib bei fortgeschrittenem hepatozellulärem Karzinom

  • T. Sauerbruch
  • A.M. Gonzalez-Carmona
  • S. Nitschmann
Klinische Studien
  • 88 Downloads

Sorafenib in advanced hepatocellular carcinoma

Notes

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Literatur

  1. 1.
    Cheng AL, Kang YK, Chen Z et al. (2009) Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 10: 25–34CrossRefPubMedGoogle Scholar
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    Hennenberg M, Trebicka J, Stark C et al. (2009) Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis. Br J Pharmacol 157: 258–270CrossRefPubMedGoogle Scholar
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    Liu L, Cao Y, Chen C et al. (2006) Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 66:11851–11858CrossRefPubMedGoogle Scholar
  4. 4.
    Llovet JM, Ricci S, Mazzaferro V et al.; SHARP Investigators Study Group (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359: 378–390CrossRefPubMedGoogle Scholar
  5. 5.
    Mejias M, Garcia-Pras E, Tiani C et al. (2009) Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats. Hepatology 49: 1245–1256CrossRefPubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag 2009

Authors and Affiliations

  • T. Sauerbruch
    • 1
  • A.M. Gonzalez-Carmona
    • 1
  • S. Nitschmann
    • 2
  1. 1.Medizinische Klinik und Poliklinik IUniversitätsklinikum BonnBonnDeutschland
  2. 2.Werl-WestönnenDeutschland

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