Skip to main content
SpringerLink
Log in

Long-term changes in multimodal intensive tinnitus therapy

A 5‑year follow-up

Langzeitveränderung bei multimodaler Tinnitustherapie

5-Jahres-Katamnese

  • Original articles
  • Published:
HNO Aims and scope Submit manuscript

An Erratum to this article was published on 09 February 2018

This article has been updated

Abstract

Background

We present 5‑year follow-up data for tinnitus-specific and comorbid depressive symptoms as well as stress-related outcome variables of an intensive multimodal 7‑day tinnitus therapy.

Method

Tinnitus burden (Tinnitus Questionnaire), stress (Perceived Stress Questionnaire), and depressive symptomatology (General Depression Scale) were measured at the 5‑year follow-up after a multimodal intensive 7‑day intervention. In all, 94 patients participated in the study.

Results

All outcome variables showed significant improvement at the end of the 7‑day intensive treatment. These effects remained significant after 5 years.

Conclusion

The results of the present study support the effectiveness of the 7‑day multimodal intensive therapy for tinnitus. Posttreatment improvements were related to both tinnitus burden as well as stress and depressive symptoms and were maintained at the 5‑year follow-up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Change history

  • 09 February 2018

    Erratum to:

References

  1. Baguley D, McFerran D, Hall D (2013) Tinnitus. Lancet 382:1600–1607

    Article  PubMed  Google Scholar 

  2. Bauer CA, Brozoski TJ (2011) Effect of tinnitus retraining therapy on the loudness and annoyance of tinnitus: a controlled trial. Ear Hear 32:145–155

    Article  PubMed  Google Scholar 

  3. Bauer CA, Berry J, Brozoski TJ (2016) Clinical trials supported by the Tinnitus Research Consortium: Lessons learned, the Southern Illinois University experience. Hear Res 334:65–71

    Article  PubMed  Google Scholar 

  4. Biesinger EH, Greimel V, Lendle T, Höning R, Albegger K (1998) Strategien in der ambulaten Behandlung des Tinnitus. HNO 46:157–169

    Article  CAS  PubMed  Google Scholar 

  5. Brüggemann P, Szczepek AJ, Rose M, McKenna L, Olze H, Mazurek B (2016) Impact of multiple factors on the degree of tinnitus distress. Front Hum Neurosci 10:341

    Article  PubMed  PubMed Central  Google Scholar 

  6. Cima RF, Maes IH, Joore MA, Scheyen DJ, El Refaie A, Baguley DM, Anteunis LJ, van Breukelen GJ, Vlaeyen JW (2012) Specialised treatment based on cognitive behaviour therapy versus usual care for tinnitus: a randomised controlled trial. Lancet 379:1951–1959

    Article  PubMed  Google Scholar 

  7. De Ridder D, Vanneste S, Weisz N, Londero A, Schlee W, Elgoyhen AB, Langguth B (2014) An integrative model of auditory phantom perception: tinnitus as a unified percept of separable subnetworks. Neurosci Biobehav Rev 44:16–32

    Article  PubMed  Google Scholar 

  8. Eggermont JJ, Roberts LE (2012) The neuroscience of tinnitus: understanding abnormal and normal auditory perception. Front Syst Neurosci 6:53

    Article  PubMed  PubMed Central  Google Scholar 

  9. Fliege H, Rose M, Arck P et al (2001) Validation of the “Perceived StressvQuestionnaire” (PSQ) in a German sample. Diagnostika 47:142–152

    Article  Google Scholar 

  10. Forti S, Costanzo S, Crocetti A, Pignataro L, Del Bo L, Ambrosetti U (2009) Are results of tinnitus retraining therapy maintained over time? 18-month follow-up after completion of therapy. Audiol Neurootol 14(5):286–289

    Article  CAS  PubMed  Google Scholar 

  11. Goebel G, Hiller W (1998) Tinnitusfragebogen (TF)—Ein Instrument zur Erfassung von Belastung und Schweregrad bei Tinnitus, Handanweisung. Hogrefe, Göttingen

    Google Scholar 

  12. Goebel G, Hiller W (1999) Assessing audiological, pathophysiological, and psychological variables in chronic tinnitus: a study of reliability and search for prognostic factors. Int J Behav Med 6(4):312–330

    Article  PubMed  Google Scholar 

  13. Georgiewa P, Bohner G, Rothemund Y, Klingebiel R, Olze H, Klapp B, Mazurek B (2012) Affective processing in tinnitus patients assessed by functional magnetic resonance imaging. Otolaryngology S3:3, 2

    Article  Google Scholar 

  14. Hautzinger M, Bailer M (1993) Allgemeine Depressionsskala. Göttingen, Hogrefe

    Google Scholar 

  15. Hesse G (2015) Innenohrschwerhörigkeit. Thieme, Stuttgart

    Book  Google Scholar 

  16. Hesse G (2016) Evidence and lack of evidence in the treatment of tinnitus. Laryngorhinootologie 95((1):155–191

    Google Scholar 

  17. Hesse G, Rienhoff NK, Nelting N, Laubert A (2001) Ergebnisse stationärer Therapie bei Patienten mit chronisch komplexem Tinnitus. Laryngorhinootologie 80(9):503–508

    Article  CAS  PubMed  Google Scholar 

  18. Hoare DJ, Hall DA (2011) Clinical guidelines and practice: a commentary on the complexity of tinnitus management. Eval Health Prof 34:413–420

    Article  PubMed  PubMed Central  Google Scholar 

  19. Hoare DJ, Kowalkowski VL, Kang S et al (2011) Systematic review and meta-analyses of randomized controlled trials examining tinnitus management. Laryngoscope 121:1555–1564

    Article  PubMed  PubMed Central  Google Scholar 

  20. Jastreboff PJ (1999) Tinnitus retraining therapy. Br J Audiol 33(1):68–70

    CAS  PubMed  Google Scholar 

  21. Jastreboff PJ (2015) 25 years of tinnitus retraining therapy. HNO 63(4):307–311

    Article  CAS  PubMed  Google Scholar 

  22. Jastreboff PJ, Hazell JW (1993) A neurophysiological approach to tinnitus: clinical implications. Br J Audiol 27:7–17

    Article  CAS  PubMed  Google Scholar 

  23. Kroener-Herwig B, Biesinger E, Gerhards F, Goebel G, Verena Greimel K, Hiller W (2000) Retraining therapy for chronic tinnitus. A critical analysis of its status. Scand Audiol 29(2):67–78

    Article  CAS  PubMed  Google Scholar 

  24. Langguth B, Kreuzer PM, Kleinjung T, De Ridder D (2013) Tinnitus: causes and clinical management. Lancet Neurol 12(9):920–930

    Article  PubMed  Google Scholar 

  25. Lopez-Escamez JA, Bibas T, Cima RF, Van de Heyning P, Knipper M, Mazurek B, Szczepek A, Cederroth CR (2016) Genetics of tinnitus: an emerging area for molecular diagnosis and drug development. Front Neurosci 19(10):377–389

    Google Scholar 

  26. Martinez-Devesa P, Perera R, Theodoulou M, Waddell A (2010) Cognitive behavioural therapy for tinnitus. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD005233.pub3

    PubMed  Google Scholar 

  27. Mazurek B, Georgiewa P, Seydel C, Haupt H, Scherer H, Klapp BF, Reisshauer A (2005) Integrated intensive treatment of tinnitus: method and initial results. Gesundheitswesen 67:485–491

    Article  CAS  PubMed  Google Scholar 

  28. Mazurek B, Fischer F, Haupt H, Georgiewa P, Reisshauer A, Klapp BF (2006) A modified version of tinnitus retraining therapy: observing long-term outcome and predictors. Audiol Neurootol 11:276–286

    Article  PubMed  Google Scholar 

  29. Phillips JS, McFerran D (2010) Tinnitus Retraining Therapy (TRT) for tinnitus. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD007330.pub2

    Google Scholar 

  30. Rauschecker JP, May ES, Maudoux A, Ploner M (2015) Frontostriatal gating of tinnitus and chronic pain. Trends Cogn Sci (Regul Ed) 19(10):567–578

    Article  Google Scholar 

  31. Seydel C, Georgiewa P, Reisshauer A, Klapp BF, Mazurek B (2008) Group therapeutic concept for chronic tinnitus. HNO 56(3):332–339

    Article  CAS  PubMed  Google Scholar 

  32. Seydel C, Haupt H, Szczepek AJ, Klapp BF, Mazurek B (2010) Long-term improvement in tinnitus after modified tinnitus retraining therapy enhanced by a variety of psychological approaches. Audiol Neurootol 15:69–80

    Article  PubMed  Google Scholar 

  33. Seydel C, Haupt H, Szczepek AJ, Hartmann A, Rose M, Mazurek B (2015) Three years later: report on the state of well-being of patients with chronic tinnitus who underwent modified tinnitus retraining therapy. Audiol Neurootol 20(1):26–38

    Article  PubMed  Google Scholar 

  34. Zirke N, Seydel C, Szczepek AJ, Olze H, Haupt H, Mazurek B (2013) Psychological comorbidity in patients with chronic tinnitus: analysis and comparison with chronic pain, asthma or atopic dermatitis patients. Qual Life Res 22(2):263–272

    Article  CAS  PubMed  Google Scholar 

  35. Zenner HP, Delb W, Kroner-Herwig B et al (2015) On the interdisciplinary S3 guidelines for the treatment of chronic idiopathic tinnitus. HNO 63:419–427

    Article  PubMed  Google Scholar 

  36. Zenner HP, Delb W, Kröner-Herwig B, Jäger B, Peroz I, Hesse G, Mazurek B, Goebel G, Gerloff C, Trollmann R, Biesinger E, Seidler H, Langguth B (2017) A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus. Eur Arch Otorhinolaryngol 274(5):2079–2091

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Tinnituszentrum, Charité – Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany

    P. Brüggemann, J. Otto, N. Lorenz, S. Schorsch, B. Böcking &  B. Mazurek

  2. Department of Otorhinolaryngology, Charité – Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany

    A. J. Szczepek

Authors
  1. P. Brüggemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Otto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Lorenz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Schorsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. J. Szczepek
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. Böcking
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B. Mazurek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B. Mazurek.

Ethics declarations

Conflict of interest

P. Brüggemann, J. Otto, N. Lorenz, S. Schorsch, A. J. Szczepek, B. Böcking, and B. Mazurek declare that they have no competing interests.

Participants gave written consent for their data to be used for research purposes. The study was approved by the local ethics committee.

The supplement containing this article is not sponsored by industry.

Additional information

An erratum to this article is available at https://doi.org/10.1007/s00106-018-0484-7.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Brüggemann, P., Otto, J., Lorenz, N. et al. Long-term changes in multimodal intensive tinnitus therapy. HNO 66 (Suppl 1), 34–38 (2018). https://doi.org/10.1007/s00106-017-0463-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00106-017-0463-4

Keywords

Search

Navigation