, Volume 60, Issue 2, pp 141–162

Leitlinie „Rhinosinusitis“ – Langfassung

S2-Leitlinie der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
  • B.A. Stuck
  • C. Bachert
  • P. Federspil
  • W. Hosemann
  • L. Klimek
  • R. Mösges
  • O. Pfaar
  • C. Rudack
  • H. Sitter
  • M. Wagenmann
  • R. Weber
  • K. Hörmann

Rhinosinusitis guidelines—unabridged version

S2 guidelines from the German Society of Otorhinolaryngology, Head and Neck Surgery


  1. 1.
    Adam P, Stiffman M, Blake RL Jr (1998) A clinical trial of hypertonic saline nasal spray in subjects with the common cold or rhinosinusitis. Arch Fam Med 7:39–43PubMedCrossRefGoogle Scholar
  2. 2.
    Ahovuo-Saloranta A, Borisenko OV, Kovanen N et al (2008) Antibiotics for acute maxillary sinusitis. Cochrane Database Syst Rev:CD000243 (EL Ia)Google Scholar
  3. 3.
    Alkire BC, Bhattacharyya N (2010) An assessment of sinonasal anatomic variants potentially associated with recurrent acute rhinosinusitis. Laryngoscope 120(3):631–634PubMedCrossRefGoogle Scholar
  4. 4.
    American Thoracic Society Workshop (1999) American Thoracic Society Workshop. Immunobiology of asthma and rhinitis. Pathogenic factors and therapeutic options. Am J Respir Crit Care Med 160:1778–1787Google Scholar
  5. 5.
    Anand VK (2004) Epidemiology and economic impact of rhinosinusitis. Ann Otol Rhinol Laryngol Suppl 193:3–5PubMedGoogle Scholar
  6. 6.
    Anzai Y, Weymuller EA Jr, Yueh B et al (2004) The impact of sinus computed tomography on treatment decisions for chronic sinusitis. Arch Otolaryngol Head Neck Surg 130:423–428PubMedCrossRefGoogle Scholar
  7. 7.
    Ashraf N, Bhattacharyya N (2001) Determination of the „incidental“ Lund score for the staging of chronic rhinosinusitis. Otolaryngol Head Neck Surg 125:483–486PubMedGoogle Scholar
  8. 8.
    AWMF (2001) Das Leitlinien-Manual von AWMF und ÄZQ. Z Ärztl Fortbild Qualitätssich 95:1–84Google Scholar
  9. 9.
    AWMF (2009) Leitlinien der Deutschen Röntgengesellschaft. Gesichtsschädel: Entzündungen. AWMF Leitlinienregister Nr. 039/037Google Scholar
  10. 10.
    Bachar G, Barker E, Nithiananthan S et al (2009) Three-dimensional tomosynthesis and cone-beam computed tomography: an experimental study for fast, low-dose intraoperative imaging technology for guidance of sinus and skull base surgery. Laryngoscope 119:434–441PubMedCrossRefGoogle Scholar
  11. 11.
    Bachert C, Gevaert P, Holtappels G et al (2001) Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol 107:607–614PubMedCrossRefGoogle Scholar
  12. 12.
    Bachert C, Gevaert P, Howarth P et al (2003) IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma. J Allergy Clin Immunol 111:1131–1132PubMedCrossRefGoogle Scholar
  13. 13.
    Bachert C, Patou J, Van Cauwenberge P (2006) The role of sinus disease in asthma. Curr Opin Allergy Clin Immunol 6:29–36PubMedCrossRefGoogle Scholar
  14. 14.
    Bachert C, Schapowal A, Funk P et al (2009) Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial. Rhinology 47:51–58PubMedGoogle Scholar
  15. 15.
    Bachert C, Van Bruaene N, Toskala E et al (2009) Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis – a GALEN study. Allergy 64:520–533PubMedCrossRefGoogle Scholar
  16. 16.
    Bachert C, Wagenmann M, Hauser U et al (1997) IL-5 synthesis is upregulated in human nasal polyp tissue. J Allergy Clin Immunol 99:837–842PubMedCrossRefGoogle Scholar
  17. 17.
    Bachert C, Wagenmann M, Rudack C et al (1998) The role of cytokines in infectious sinusitis and nasal polyposis. Allergy 53:2–13PubMedCrossRefGoogle Scholar
  18. 18.
    Bachmann G, Hommel G, Michel O (2000) Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. Eur Arch Otorhinolaryngol 257:537–541PubMedCrossRefGoogle Scholar
  19. 19.
    Badia L, Lund V (2001) Topical corticosteroids in nasal polyposis. Drugs 61:573–578PubMedCrossRefGoogle Scholar
  20. 20.
    Baenkler HW (2008) Salicylate intolerance: pathophysiology, clinical spectrum, diagnosis and treatment. Dtsch Arztebl Int 105:137–142PubMedGoogle Scholar
  21. 21.
    Bajaj Y, Sethi N, Carr S et al (2009) Endoscopic sinus surgery as day-case procedure. J Laryngol Otol 123:619–622PubMedCrossRefGoogle Scholar
  22. 22.
    Bauchau V, Durham SR (2004) Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 24:758–764PubMedCrossRefGoogle Scholar
  23. 23.
    Baumann I, Blumenstock G, Zalaman IM et al (2007) Impact of gender, age, and comorbidities on quality of life in patients with chronic rhinosinusitis. Rhinology 45:268–272PubMedGoogle Scholar
  24. 24.
    Bayonne E, Kania R, Tran P et al (2009) Intracranial complications of rhinosinusitis. A review, typical imaging data and algorithm of management. Rhinology 47:59–65PubMedGoogle Scholar
  25. 25.
    Becker SS, Bomeli SR, Gross CW et al (2006) Limits of endoscopic visualization and instrumentation in the frontal sinus. Otolaryngol Head Neck Surg 135:917–921PubMedCrossRefGoogle Scholar
  26. 26.
    Behrbohm H, Kaschke O, Sydow K (1995) Der Einfluss des pflanzlichen Sekretolytikums Gelomyrtol forte auf die mukoziliäre Clearance der Kieferhöhle. Laryngorhinootologie 74:733–737PubMedCrossRefGoogle Scholar
  27. 27.
    Benninger MS, Ferguson BJ, Hadley JA et al (2003) Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg 129:1–32CrossRefGoogle Scholar
  28. 28.
    Benninger MS, Payne SC, Ferguson BJ et al (2006) Endoscopically directed middle meatal cultures versus maxillary sinus taps in acute bacterial maxillary rhinosinusitis: a meta-analysis. Otolaryngol Head Neck Surg 134:3–9 (EL Ia)PubMedCrossRefGoogle Scholar
  29. 29.
    Benninger MS, Sedory Holzer SE, Lau J (2000) Diagnosis and treatment of uncomplicated acute bacterial rhinosinusitis: summary of the Agency for Health Care Policy and Research evidence-based report. Otolaryngol Head Neck Surg 122:1–7PubMedCrossRefGoogle Scholar
  30. 30.
    Berg O, Carenfelt C (1988) Analysis of symptoms and clinical signs in the maxillary sinus empyema. Acta Otolaryngol 105:343–349PubMedCrossRefGoogle Scholar
  31. 31.
    Berg O, Carenfelt C (1985) Etiological diagnosis in sinusitis: ultrasonography as clinical complement. Laryngoscope 95:851–853PubMedGoogle Scholar
  32. 32.
    Berg O, Carenfelt C, Kronvall G (1988) Bacteriology of maxillary sinusitis in relation to character of inflammation and prior treatment. Scand J Infect Dis 20:511–516PubMedCrossRefGoogle Scholar
  33. 33.
    Berg O, Carenfelt C, Rystedt G et al (1986) Occurrence of asymptomatic sinusitis in common cold and other acute ENT-infections. Rhinology 24:223–225PubMedGoogle Scholar
  34. 34.
    Berges-Gimeno MP, Simon RA, Stevenson DD (2003) Long-term treatment with aspirin desensitization in asthmatic patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol 111:180–186PubMedCrossRefGoogle Scholar
  35. 35.
    Bhattacharyya N (2010) Ambulatory sinus and nasal surgery in the United States: demographics and perioperative outcomes. Laryngoscope 120:635–638PubMedCrossRefGoogle Scholar
  36. 36.
    Bhattacharyya N (2009) Contemporary assessment of the disease burden of sinusitis. Am J Rhinol Allergy 23:392–395PubMedCrossRefGoogle Scholar
  37. 37.
    Bhattacharyya N (2003) The economic burden and symptom manifestations of chronic rhinosinusitis. Am J Rhinol 17:27–32PubMedGoogle Scholar
  38. 38.
    Bhattacharyya N (1999) Test-retest reliability of computed tomography in the assessment of chronic rhinosinusitis. Laryngoscope 109:1055–1058PubMedCrossRefGoogle Scholar
  39. 39.
    Bousquet J, Bachert C, Canonica GW et al (2009) Unmet needs in severe chronic upper airway disease (SCUAD). J Allergy Clin Immunol 124:428–433PubMedCrossRefGoogle Scholar
  40. 40.
    Bousquet J, Khaltaev N, Cruz AA et al (2008) Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 63(Suppl 86):8–160PubMedCrossRefGoogle Scholar
  41. 41.
    Braun JJ, Alabert JP, Michel FB et al (1997) Adjunct effect of loratadine in the treatment of acute sinusitis in patients with allergic rhinitis. Allergy 52:650–655PubMedCrossRefGoogle Scholar
  42. 42.
    Braunstahl GJ (2007) The united airways concept: from bench to bedside. Monaldi Arch Chest Dis 67:95–101PubMedGoogle Scholar
  43. 43.
    Bresciani M, Paradis L, Des Roches A et al (2001) Rhinosinusitis in severe asthma. J Allergy Clin Immunol 107:73–80PubMedCrossRefGoogle Scholar
  44. 44.
    Brook I (2001) Sinusitis – overcoming bacterial resistance. Int J Pediatr Otorhinolaryngol 58:27–36PubMedCrossRefGoogle Scholar
  45. 45.
    Brook I, Thompson DH, Frazier EH (1994) Microbiology and management of chronic maxillary sinusitis. Arch Otolaryngol Head Neck Surg 120:1317–1320PubMedCrossRefGoogle Scholar
  46. 46.
    Brook I, Yocum P, Frazier EH (1996) Bacteriology and beta-lactamase activity in acute and chronic maxillary sinusitis. Arch Otolaryngol Head Neck Surg 122:418–422 (discussion 423)PubMedCrossRefGoogle Scholar
  47. 47.
    Browne JP, Hopkins C, Slack R et al (2006) Health-related quality of life after polypectomy with and without additional surgery. Laryngoscope 116:297–302PubMedCrossRefGoogle Scholar
  48. 48.
    Bucher HC, Tschudi P, Young J et al (2003) Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis: a placebo-controlled, double-blind, randomized trial in general practice. Arch Intern Med 163:1793–1798PubMedCrossRefGoogle Scholar
  49. 49.
    Bugten V, Nordgard S, Steinsvag S (2006) The effects of debridement after endoscopic sinus surgery. Laryngoscope 116:2037–2043PubMedCrossRefGoogle Scholar
  50. 50.
    Bugten V, Nordgard S, Steinsvag S (2008) Long-term effects of postoperative measures after sinus surgery. Eur Arch Otorhinolaryngol 265:531–537PubMedCrossRefGoogle Scholar
  51. 51.
    Burke TF, Guertler AT, Timmons JH (1994) Comparison of sinus x-rays with computed tomography scans in acute sinusitis. Acad Emerg Med 1:235–239PubMedCrossRefGoogle Scholar
  52. 52.
    Canonica GW, Bousquet J, Mullol J et al (2007) A survey of the burden of allergic rhinitis in Europe. Allergy 62(Suppl 85):17–25PubMedCrossRefGoogle Scholar
  53. 53.
    Casiano RR (1997) Correlation of clinical examination with computer tomography in paranasal sinus disease. Am J Rhinol 11:193–196PubMedCrossRefGoogle Scholar
  54. 54.
    Cervin A, Kalm O, Sandkull P et al (2002) One-year low-dose erythromycin treatment of persistent chronic sinusitis after sinus surgery: clinical outcome and effects on mucociliary parameters and nasal nitric oxide. Otolaryngol Head Neck Surg 126:481–489PubMedCrossRefGoogle Scholar
  55. 55.
    Cervin A, Wallwork B (2009) Macrolides and their role in the treatment of CRS. In: Stucker F (ed) Rhinology and Facial Plastic Surgery. Springer, New York, p 295–303Google Scholar
  56. 56.
    Chakrabarti A, Denning DW, Ferguson BJ et al (2009) Fungal rhinosinusitis: a categorization and definitional schema addressing current controversies. Laryngoscope 119:1809–1818PubMedCrossRefGoogle Scholar
  57. 57.
    Chalton R, Mackay I, Wilson R et al (1985) Double blind, placebo controlled trial of betamethasone nasal drops for nasal polyposis. Br Med J (Clin Res Ed) 291:788CrossRefGoogle Scholar
  58. 58.
    Chen Y, Dales R, Lin M (2003) The epidemiology of chronic rhinosinusitis in Canadians. Laryngoscope 113:1199–1205PubMedCrossRefGoogle Scholar
  59. 59.
    Cherry DK, Woodwell DA, Rechtsteiner EA (2007) National Ambulatory Medical Care Survey: 2005 summary. Adv Data:1–39Google Scholar
  60. 60.
    Chester AC, Antisdel JL, Sindwani R (2009) Symptom-specific outcomes of endoscopic sinus surgery: a systematic review. Otolaryngol Head Neck Surg 140:633–639PubMedCrossRefGoogle Scholar
  61. 61.
    Chester AC, Sindwani R, Smith TL et al (2008) Fatigue improvement following endoscopic sinus surgery: a systematic review and meta-analysis. Laryngoscope 118:730–739PubMedCrossRefGoogle Scholar
  62. 62.
    Chester AC, Sindwani R, Smith TL et al (2008) Systematic review of change in bodily pain after sinus surgery. Otolaryngol Head Neck Surg 139:759–765PubMedCrossRefGoogle Scholar
  63. 63.
    Church CA, Chiu AG, Vaughan WC (2003) Endoscopic repair of large skull base defects after powered sinus surgery. Otolaryngol Head Neck Surg 129:204–209PubMedCrossRefGoogle Scholar
  64. 64.
    Clayman GL, Adams GL, Paugh DR et al (1991) Intracranial complications of paranasal sinusitis: a combined institutional review. Laryngoscope 101:234–239PubMedCrossRefGoogle Scholar
  65. 65.
    Coffey CS, Sonnenburg RE, Melroy CT et al (2006) Endoscopically guided aerobic cultures in postsurgical patients with chronic rhinosinusitis. Am J Rhinol 20:72–76PubMedGoogle Scholar
  66. 66.
    Cohen AN, Wang MB (2007) Minitrephination as an adjunctive measure in the endoscopic management of complex frontal sinus disease. Am J Rhinol 21:629–636PubMedCrossRefGoogle Scholar
  67. 67.
    Cohen M, Kofonow J, Nayak JV et al (2009) Biofilms in chronic rhinosinusitis: a review. Am J Rhinol Allergy 23:255–260PubMedCrossRefGoogle Scholar
  68. 68.
    Cohen NA, Kennedy DW (2006) Revision endoscopic sinus surgery. Otolaryngol Clin North Am 39:417–435, viiPubMedCrossRefGoogle Scholar
  69. 69.
    Collins JG (1997) Prevalence of selected chronic conditions: United States, 1990–1992. Vital Health Stat 10:1–89Google Scholar
  70. 70.
    Corriveau MN, Zhang N, Holtappels G et al (2009) Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization. Am J Rhinol Allergy 23:461–465PubMedCrossRefGoogle Scholar
  71. 71.
    Cutler JL, Duncavage JA, Matheny K et al (2003) Results of Caldwell-Luc after failed endoscopic middle meatus antrostomy in patients with chronic sinusitis. Laryngoscope 113:2148–2150PubMedCrossRefGoogle Scholar
  72. 72.
    Dalziel K, Stein K, Round A et al (2006) Endoscopic sinus surgery for the excision of nasal polyps: A systematic review of safety and effectiveness. Am J Rhinol 20:506–519PubMedCrossRefGoogle Scholar
  73. 73.
    Dalziel K, Stein K, Round A et al (2003) Systematic review of endoscopic sinus surgery for nasal polyps. Health Technol Assess 7:1–159, iiiGoogle Scholar
  74. 74.
    Dammann F (2007) Bildgebung der Nasennebenhohlen (NNH) in der heutigen Zeit. Radiologe 47:576, 578–583PubMedCrossRefGoogle Scholar
  75. 75.
    Bock GH de, Dekker FW, Stolk J et al (1997) Antimicrobial treatment in acute maxillary sinusitis: a meta-analysis. J Clin Epidemiol 50:881–890 (EL Ia)PubMedCrossRefGoogle Scholar
  76. 76.
    Bock GH de, Houwing-Duistermaat JJ, Springer MP et al (1994) Sensitivity and specificity of diagnostic tests in acute maxillary sinusitis determined by maximum likelihood in the absence of an external standard. J Clin Epidemiol 47:1343–1352PubMedCrossRefGoogle Scholar
  77. 77.
    Ferranti SD de, Ioannidis JP, Lau J et al (1998) Are amoxycillin and folate inhibitors as effective as other antibiotics for acute sinusitis? A meta-analysis. BMJ 317:632–637 (EL Ia)PubMedCrossRefGoogle Scholar
  78. 78.
    DeShazo RD, O’Brien M, Chapin K et al (1997) Criteria for the diagnosis of sinus mycetoma. J Allergy Clin Immunol 99:475–485PubMedCrossRefGoogle Scholar
  79. 79.
    Desrosiers M, Ferguson B, Klossek J et al (2006) Clinical efficacy, time to symptom resolution, and tolerability of telithromycin vs amoxicillin-clavulanate in acute bacterial sinusitis. In: Abstracts of the 46th international conference on antimicrobial agents and chemotherapy. San Francisco, CA, USA, p Abstract L-1448Google Scholar
  80. 80.
    Deuschl H, Drettner B (1977) Nasal polyps treated by beclomethasone nasal aerosol. Rhinology 15:17–23PubMedGoogle Scholar
  81. 81.
    Dixon AE (2009) Rhinosinusitis and asthma: the missing link. Curr Opin Pulm Med 15:19–24PubMedCrossRefGoogle Scholar
  82. 82.
    Dolor RJ, Witsell DL, Hellkamp AS et al (2001) Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial. JAMA 286:3097–3105PubMedCrossRefGoogle Scholar
  83. 83.
    Douglas RM, Hemila H, D’Souza R et al (2004) Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev:CD000980Google Scholar
  84. 84.
    Draf W (1991) Endonasal micro-endoscopic frontal sinus surgery, the Fulda concept. Oper Tech Otolaryngol Head Neck Surg 2:234–240CrossRefGoogle Scholar
  85. 85.
    Dubin MG, Kuhn FA, Melroy CT (2007) Radiographic resolution of chronic rhinosinusitis without polyposis after 6 weeks vs 3 weeks of oral antibiotics. Ann Allergy Asthma Immunol 98:32–35PubMedCrossRefGoogle Scholar
  86. 86.
    Durr DG, Desrosiers MY, Dassa C (2001) Impact of rhinosinusitis in health care delivery: the Quebec experience. J Otolaryngol 30:93–97PubMedCrossRefGoogle Scholar
  87. 87.
    Dykewicz MS, Hamilos DL (2010) Rhinitis and sinusitis. J Allergy Clin Immunol 125:103–115CrossRefGoogle Scholar
  88. 88.
    Ebbens FA, Scadding GK, Badia L et al (2006) Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 118:1149–1156PubMedCrossRefGoogle Scholar
  89. 89.
    Eccles R, Jawad MS, Morris S (1990) The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. J Pharm Pharmacol 42:652–654PubMedCrossRefGoogle Scholar
  90. 90.
    Eggers G, Klein J, Welzel T et al (2008) Geometric accuracy of digital volume tomography and conventional computed tomography. Br J Oral Maxillofac Surg 46:639–644PubMedCrossRefGoogle Scholar
  91. 91.
    Eggesbo HB (2006) Radiological imaging of inflammatory lesions in the nasal cavity and paranasal sinuses. Eur Radiol 16:872–888PubMedCrossRefGoogle Scholar
  92. 92.
    Eichner KG, Wimmer M (1987) Zur Akupunkturbehandlung bei Kindern und Erwachsenen. Akupunktur Theorie und Praxis 15:6–14Google Scholar
  93. 93.
    Elies W, Bestehorn M, Thate-Waschke I (2007) Häufigkeit und Therapie der Sinusitis Chemotherapie Journal 16:167–175Google Scholar
  94. 94.
    Engels EA, Terrin N, Barza M et al (2000) Meta-analysis of diagnostic tests for acute sinusitis. J Clin Epidemiol 53:852–862PubMedCrossRefGoogle Scholar
  95. 95.
    Esposito S, Bosis S, Bellasio M et al (2007) From clinical practice to guidelines: how to recognize rhinosinusitis in children. Pediatr Allergy Immunol 18(Suppl 18):53–55PubMedCrossRefGoogle Scholar
  96. 96.
    Federspil P (2009) Antibiotikatherapie der Infektionen an Kopf und Hals. Konsensusbericht, im Auftrag des Präsidiums der Deutschen Gesellschaft fur Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Laryngorhinootologie 88:329–338PubMedCrossRefGoogle Scholar
  97. 97.
    Federspil P, Federspil PA (2005) Antibiotikatherapie in der Hals-Nasen-Ohren-Heilkunde. HNO 53:11–28PubMedCrossRefGoogle Scholar
  98. 98.
    Federspil P, Elies W, Luckhaupt H et al (2003) Leitlinien zur Antibiotika-Therapie der bakteriellen Infektionen an Kopf und Hals. Arzneimitteltherapie 21:162–175Google Scholar
  99. 99.
    Federspil P, Wulkow R, Zimmermann T (1997) Wirkung von Myrtol standardisiert bei der Therapie der akuten Sinusitis – Ergebnisse einer doppelblinden, randomisierten Multicenterstudie gegen Plazebo. Laryngorhinootologie 76:23–27 (EL Ib)PubMedCrossRefGoogle Scholar
  100. 100.
    Felisati G, Ramadan H (2007) Rhinosinusitis in children: the role of surgery. Pediatr Allergy Immunol 18(Suppl 18):68–70PubMedCrossRefGoogle Scholar
  101. 101.
    Filiaci F, Passali D, Puxeddu R et al (2000) A randomized controlled trial showing efficacy of once daily intranasal budesonide in nasal polyposis. Rhinology 38:185–190PubMedGoogle Scholar
  102. 102.
    Fokkens W, Lund V, Bachert C et al (2005) EAACI position paper on rhinosinusitis and nasal polyps executive summary. Allergy 60:583–601PubMedCrossRefGoogle Scholar
  103. 103.
    Fokkens W, Lund V, Mullol J et al (2007) European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl (20):1–136Google Scholar
  104. 104.
    Foreman A, Psaltis AJ, Tan LW et al (2009) Characterization of bacterial and fungal biofilms in chronic rhinosinusitis. Am J Rhinol Allergy 23:556–561PubMedCrossRefGoogle Scholar
  105. 105.
    Foreman A, Singhal D, Psaltis AJ et al (2010) Targeted imaging modality selection for bacterial biofilms in chronic rhinosinusitis. Laryngoscope 120:427–431PubMedCrossRefGoogle Scholar
  106. 106.
    Foreman A, Wormald PJ (2010) Different biofilms, different disease? A clinical outcomes study. Laryngoscope 120:1701–1706PubMedCrossRefGoogle Scholar
  107. 107.
    Fox RW, Lockey RF (2003) The impact of rhinosinusitis on asthma. Curr Allergy Asthma Rep 3:513–518PubMedCrossRefGoogle Scholar
  108. 108.
    Fried MP, Moharir VM, Shin J et al (2002) Comparison of endoscopic sinus surgery with and without image guidance. Am J Rhinol 16:193–197PubMedGoogle Scholar
  109. 109.
    Fried MP, Sadoughi B, Gibber MJ et al (2010) From virtual reality to the operating room: the endoscopic sinus surgery simulator experiment. Otolaryngol Head Neck Surg 142:202–207PubMedCrossRefGoogle Scholar
  110. 110.
    Friese KH, Zabalotnyi DI (2007) Homoopathie bei akuter Rhinosinusitis: Eine doppelblinde, placebokontrollierte Studie belegt die Wirksamkeit und Vertraglichkeit eines homoopathischen Kombinationsarzneimittels. HNO 55:271–277PubMedCrossRefGoogle Scholar
  111. 111.
    Gaga M, Lambrou P, Papageorgiou N et al (2000) Eosinophils are a feature of upper and lower airway pathology in non-atopic asthma, irrespective of the presence of rhinitis. Clin Exp Allergy 30:663–669PubMedCrossRefGoogle Scholar
  112. 112.
    Gallagher RM, Gross CW, Phillips CD (1998) Suppurative intracranial complications of sinusitis. Laryngoscope 108:1635–1642PubMedCrossRefGoogle Scholar
  113. 113.
    Gevaert P, Claeys S, Bachert C (2009) ESS for nasal polyposis. In: Stucker F (ed) Rhinology and Facial Plastic Surgery. Springer, New York, p 593–599Google Scholar
  114. 114.
    Gevaert P, Holtappels G, Johansson SG et al (2005) Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue. Allergy 60:71–79PubMedCrossRefGoogle Scholar
  115. 115.
    Gliklich RE, Metson R (1998) Economic implications of chronic sinusitis. Otolaryngol Head Neck Surg 118:344–349PubMedCrossRefGoogle Scholar
  116. 116.
    Gliklich RE, Metson R (1995) The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg 113:104–109PubMedCrossRefGoogle Scholar
  117. 117.
    Gold SM, Tami TA (1997) Role of middle meatus aspiration culture in the diagnosis of chronic sinusitis. Laryngoscope 107:1586–1589PubMedCrossRefGoogle Scholar
  118. 118.
    Gosepath J, Hoffmann F, Schafer D et al (1999) Aspirin intolerance in patients with chronic sinusitis. ORL J Otorhinolaryngol Relat Spec 61:146–150PubMedCrossRefGoogle Scholar
  119. 119.
    Gosepath J, Pogodsky T, Mann WJ (2008) Characteristics of recurrent chronic rhinosinusitis after previous surgical therapy. Acta Otolaryngol 128:778–784PubMedCrossRefGoogle Scholar
  120. 120.
    Graham SM, Nerad JA (2003) Orbital complications in endoscopic sinus surgery using powered instrumentation. Laryngoscope 113:874–878PubMedCrossRefGoogle Scholar
  121. 121.
    Grosjean P, Weber R (2007) Fungus balls of the paranasal sinuses: a review. Eur Arch Otorhinolaryngol 264:461–470PubMedCrossRefGoogle Scholar
  122. 122.
    Gwaltney JM (1994) Microbiology of sinusitis. In: Druce HM (ed) Sinusitis: Pathophysiology and Treatment (Clinical Allergy and Immunology Series). Marcel Dekker, New YorkGoogle Scholar
  123. 123.
    Gwaltney JM Jr, Jones JG, Kennedy DW (1995) Medical management of sinusitis: educational goals and management guidelines. The International Conference on sinus Disease. Ann Otol Rhinol Laryngol Suppl 167:22–30PubMedGoogle Scholar
  124. 124.
    Gwaltney JM Jr, Phillips CD, Miller RD et al (1994) Computed tomographic study of the common cold. N Engl J Med 330:25–30PubMedCrossRefGoogle Scholar
  125. 125.
    Gwaltney JM Jr, Wiesinger BA, Patrie JT (2004) Acute community-acquired bacterial sinusitis: the value of antimicrobial treatment and the natural history. Clin Infect Dis 38:227–233PubMedCrossRefGoogle Scholar
  126. 126.
    Hackman TG, Ferguson BJ (2005) Powered instrumentation and tissue effects in the nose and paranasal sinuses. Curr Opin Otolaryngol Head Neck Surg 13:22–26PubMedCrossRefGoogle Scholar
  127. 127.
    Hahn S, Palmer JN, Purkey MT et al (2009) Indications for external frontal sinus procedures for inflammatory sinus disease. Am J Rhinol Allergy 23:342–347PubMedCrossRefGoogle Scholar
  128. 128.
    Han DH, An SY, Kim SW et al (2007) Primary and secondary fungal infections of the paranasal sinuses: clinical features and treatment outcomes. Acta Otolaryngol Suppl:78–82CrossRefGoogle Scholar
  129. 129.
    Hansen JG, Schmidt H, Rosborg J et al (1995) Predicting acute maxillary sinusitis in a general practice population. BMJ 311:233–236PubMedCrossRefGoogle Scholar
  130. 130.
    Hartwig S, Linden M, Laurent C et al (1988) Budesonide nasal spray as prophylactic treatment after polypectomy (a double blind clinical trial). J Laryngol Otol 102:148–151PubMedCrossRefGoogle Scholar
  131. 131.
    Harvey R, Hannan SA, Badia L et al (2007) Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev:CD006394Google Scholar
  132. 132.
    Hashiba M, Baba S (1996) Efficacy of long-term administration of clarithromycin in the treatment of intractable chronic sinusitis. Acta Otolaryngol Suppl 525:73–78PubMedGoogle Scholar
  133. 133.
    Healy DY, Leid JG, Sanderson AR et al (2008) Biofilms with fungi in chronic rhinosinusitis. Otolaryngol Head Neck Surg 138:641–647PubMedCrossRefGoogle Scholar
  134. 134.
    Heatley DG, McConnell KE, Kille TL et al (2001) Nasal irrigation for the alleviation of sinonasal symptoms. Otolaryngol Head Neck Surg 125:44–48PubMedCrossRefGoogle Scholar
  135. 135.
    Hedman J, Kaprio J, Poussa T et al (1999) Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 28:717–722PubMedCrossRefGoogle Scholar
  136. 136.
    Heikkinen T, Jarvinen A (2003) The common cold. Lancet 361:51–59PubMedCrossRefGoogle Scholar
  137. 137.
    Hellquist HB (1996) Nasal polyps update. Histopathology. Allergy Asthma Proc 17:237–242PubMedCrossRefGoogle Scholar
  138. 138.
    Hissaria P, Smith W, Wormald PJ et al (2006) Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures. J Allergy Clin Immunol 118:128–133 (EL Ib)PubMedCrossRefGoogle Scholar
  139. 139.
    Hochstim CJ, Choi JY, Lowe D et al (2010) Biofilm detection with hematoxylin-eosin staining. Arch Otolaryngol Head Neck Surg 136:453–456PubMedCrossRefGoogle Scholar
  140. 140.
    Holmberg K, Juliusson S, Balder B et al (1997) Fluticasone propionate aqueous nasal spray in the treatment of nasal polyposis. Ann Allergy Asthma Immunol 78:270–276PubMedCrossRefGoogle Scholar
  141. 141.
    Holzmuller A, Gudziol H, Muller A (2009) Lebensqualität nach funktionell-endoskopischer Nasennebenhöhlen-Operation bei Polyposis nasi (Eine Langzeitstudie). Laryngorhinootologie 88:174–180PubMedCrossRefGoogle Scholar
  142. 142.
    Hopkins C, Browne J, Slack R et al (2007) Variation in day-case nasal surgery – why cannot we improve our day-case rates? Clin Otolaryngol 32:12–18PubMedCrossRefGoogle Scholar
  143. 143.
    Hopkins C, Slack R, Lund V et al (2009) Long-term outcomes from the English national comparative audit of surgery for nasal polyposis and chronic rhinosinusitis. Laryngoscope 119:2459–2465PubMedCrossRefGoogle Scholar
  144. 144.
    Hosemann W (2001) Innere Nase und Nasennebenhöhlen. In: Strutz J, Mann W (Hrsg) Praxis der HNO-Heilkunde, Kopf- und Halschirurgie. Thieme, Stuttgart, S 342–390Google Scholar
  145. 145.
    Hosemann W (2003) Postoperative Rezidivprophylaxe bei chronischer Pansinusitis und Polyposis nasi. HNO 51:279–283PubMedCrossRefGoogle Scholar
  146. 146.
    Hosemann W (2009) Stellungnahme der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie zur Ballon-Dilatation der Ostien bzw. der Drainagewege von Nasennebenhöhlen („Ballon-Sinuplasty, balloon catheter sinusotomy, balloon catheter sinus ostial dilation“). HNO-Informationen 34:48–49Google Scholar
  147. 147.
    Hosemann W, Fanghänel J (2005) Präparierkurs zur endoskopischen endonasalen Nasennebenhöhlenchirurgie. Endo-Press, TuttlingenGoogle Scholar
  148. 148.
    Hosemann W, Schwab N, Praetner L et al (2003) Lebensqualität nach funktionell-endoskopischer Nasennebenhöhlen-Operation bei Polyposis nasi (Eine Langzeitstudie). Laryngorhinootologie 82:341–346PubMedCrossRefGoogle Scholar
  149. 149.
    Hosemann W, Scotti O, Bentzien S (2003) Evaluation of telescopes and forceps for endoscopic transnasal surgery on the maxillary sinus. Am J Rhinol 17:311–316PubMedGoogle Scholar
  150. 150.
    Hosemann W, Weber R, Keerl R et al (2000) Minimally invasive endonasal sinus surgery – principles, techniques, results, complications, revision surgery. Thieme, StuttgartGoogle Scholar
  151. 151.
    Hosemann W, Wigand ME, Gode U et al (1991) Normal wound healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol 248:390–394PubMedCrossRefGoogle Scholar
  152. 152.
    Huang BY, Lloyd KM, DelGaudio JM et al (2009) Failed endoscopic sinus surgery: spectrum of CT findings in the frontal recess. Radiographics 29:177–195PubMedCrossRefGoogle Scholar
  153. 153.
    Hwang PH, Irwin SB, Griest SE et al (2003) Radiologic correlates of symptom-based diagnostic criteria for chronic rhinosinusitis. Otolaryngol Head Neck Surg 128:489–496PubMedCrossRefGoogle Scholar
  154. 154.
    Iinuma T, Hirota Y, Kase Y (1994) Radio-opacity of the paranasal sinuses. Conventional views and CT. Rhinology 32:134–136PubMedGoogle Scholar
  155. 155.
    IMS (2002) Institut für medizinische Statistik GmbH. FrankfurtGoogle Scholar
  156. 156.
    Jankowski R, Bodino C (2003) Evolution of symptoms associated to nasal polyposis following oral steroid treatment and nasalization of the ethmoid–radical ethmoidectomy is functional surgery for NPS. Rhinology 41:211–219PubMedGoogle Scholar
  157. 157.
    Jankowski R, Pigret D, Decroocq F (1997) Comparison of functional results after ethmoidectomy and nasalization for diffuse and severe nasal polyposis. Acta Otolaryngol 117:601–608PubMedCrossRefGoogle Scholar
  158. 158.
    Jankowski R, Pigret D, Decroocq F et al (2006) Comparison of radical (nasalisation) and functional ethmoidectomy in patients with severe sinonasal polyposis. A retrospective study. Rev Laryngol Otol Rhinol (Bord) 127:131–140Google Scholar
  159. 159.
    Joe SA, Thambi R, Huang J (2008) A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis. Otolaryngol Head Neck Surg 139:340–347PubMedCrossRefGoogle Scholar
  160. 160.
    Jones NS (2002) CT of the paranasal sinuses: a review of the correlation with clinical, surgical and histopathological findings. Clin Otolaryngol Allied Sci 27:11–17PubMedCrossRefGoogle Scholar
  161. 161.
    Jones NS, Walker JL, Bassi S et al (2002) The intracranial complications of rhinosinusitis: can they be prevented? Laryngoscope 112:59–63PubMedCrossRefGoogle Scholar
  162. 162.
    Kaiser L, Lew D, Hirschel B et al (1996) Effects of antibiotic treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. Lancet 347:1507–1510PubMedCrossRefGoogle Scholar
  163. 163.
    Kalish LH, Arendts G, Sacks R et al (2009) Topical steroids in chronic rhinosinusitis without polyps: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 141:674–683PubMedCrossRefGoogle Scholar
  164. 164.
    Kaplan BA, Kountakis SE (2004) Role of nasal endoscopy in patients undergoing endoscopic sinus surgery. Am J Rhinol 18:161–164PubMedGoogle Scholar
  165. 165.
    Karageorgopoulos DE, Giannopoulou KP, Grammatikos AP et al (2008) Fluoroquinolones compared with beta-lactam antibiotics for the treatment of acute bacterial sinusitis: a meta-analysis of randomized controlled trials. CMAJ 178:845–854 (EL Ia)PubMedCrossRefGoogle Scholar
  166. 166.
    Karlsson G, Rundcrantz H (1982) A randomized trial of intranasal beclomethasone dipropionate after polypectomy. Rhinology 20:144–148PubMedGoogle Scholar
  167. 167.
    Kassel JC, King D, Spurling GK (2010) Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Database Syst Rev 3:CD006821PubMedGoogle Scholar
  168. 168.
    Keerl R, Stankiewicz J, Weber R et al (1999) Surgical experience and complications during endonasal sinus surgery. Laryngoscope 109:546–550PubMedCrossRefGoogle Scholar
  169. 169.
    Keerl R, Weber R, Drees G et al (1996) Individuelle Lernkurven der endonasalen mikro-endoskopischen Pansinusoperation. Laryngorhinootologie 75:338–343PubMedCrossRefGoogle Scholar
  170. 170.
    Kehrl W, Sonnemann U, Dethlefsen U (2004) Therapy for acute nonpurulent rhinosinusitis with cineole: results of a double-blind, randomized, placebo-controlled trial. Laryngoscope 114:738–742PubMedCrossRefGoogle Scholar
  171. 171.
    Keith P, Nieminen J, Hollingworth K et al (2000) Efficacy and tolerability of fluticasone propionate nasal drops 400 μg once daily compared with placebo for the treatment of bilateral polyposis in adults. Clin Exp Allergy 30:1460–1468PubMedCrossRefGoogle Scholar
  172. 172.
    Kenny TJ, Duncavage J, Bracikowski J et al (2001) Prospective analysis of sinus symptoms and correlation with paranasal computed tomography scan. Otolaryngol Head Neck Surg 125:40–43PubMedCrossRefGoogle Scholar
  173. 173.
    Kern RC, Conley DB, Walsh W et al (2008) Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis. Am J Rhinol 22:549–559PubMedCrossRefGoogle Scholar
  174. 174.
    Khalil HS, Nunez DA (2006) Functional endoscopic sinus surgery for chronic rhinosinusitis. Cochrane Database Syst Rev 3:CD004458PubMedGoogle Scholar
  175. 175.
    Kilty SJ, Desrosiers MY (2008) The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis. Curr Allergy Asthma Rep 8:227–233PubMedCrossRefGoogle Scholar
  176. 176.
    Klimek L, Bachert C (2000) Aktuelle Aspekte der nasalen Glukokortikosteroidtherapie. HNO 48:544–555PubMedCrossRefGoogle Scholar
  177. 177.
    Klimek L, Pfaar O (2009) Aspirin intolerance: does desensitization alter the course of the disease? Immunol Allergy Clin North Am 29:669–675PubMedCrossRefGoogle Scholar
  178. 178.
    Klossek JM, Dubreuil L, Richet H et al (1998) Bacteriology of chronic purulent secretions in chronic rhinosinusitis. J Laryngol Otol 112:1162–1166PubMedCrossRefGoogle Scholar
  179. 179.
    Klossek JM, Federspil P (2005) Update on treatment guidelines for acute bacterial sinusitis. Int J Clin Pract 59:230–238PubMedCrossRefGoogle Scholar
  180. 180.
    Kosling S, Knipping S, Stoevesandt D (2007) Tumoren und tumorahnliche Erkrankungen. Radiologe 47:613–620PubMedCrossRefGoogle Scholar
  181. 181.
    Kountakis S, Jacobs J, Gosepath J (2008) Revision Sinus Surgery. Springer, HeidelbergGoogle Scholar
  182. 182.
    Krouse JH, Brown RW, Fineman SM et al (2007) Asthma and the unified airway. Otolaryngol Head Neck Surg 136:75–106CrossRefGoogle Scholar
  183. 183.
    Kuhnel T, Hosemann W, Wagner W et al (1996) Wie traumatisierend ist die mechanische Schleimhautpflege nach Eingriffen an den Nasennebenhohlen? Eine histologisch-immunhistochemische Untersuchung. Laryngorhinootologie 75:575–579PubMedCrossRefGoogle Scholar
  184. 184.
    Lacroix JS, Ricchetti A, Lew D et al (2002) Symptoms and clinical and radiological signs predicting the presence of pathogenic bacteria in acute rhinosinusitis. Acta Otolaryngol 122:192–196PubMedCrossRefGoogle Scholar
  185. 185.
    Lambrou P, Zervas E, Oikonomidou E et al (2007) Eosinophilic infiltration in the nasal mucosa of rhinitis patients: is it affected by the presence of asthma or the allergic status of the patients? Ann Allergy Asthma Immunol 98:567–572PubMedCrossRefGoogle Scholar
  186. 186.
    Lane AP, Pine HS, Pillsbury HC 3rd (2001) Allergy testing and immunotherapy in an academic otolaryngology practice: a 20-year review. Otolaryngol Head Neck Surg 124:9–15PubMedCrossRefGoogle Scholar
  187. 187.
    Lang S, Jager L, Grevers G (2002) Zur Aussagefähigkeit koronarer Sekundärrekonstruktionen computertomographischer Sequenzen der Nasennebenhöhlen. Laryngorhinootologie 81:418–421PubMedCrossRefGoogle Scholar
  188. 188.
    Lange B, Bachert C (2003) Die topische intranasale Therapie der allergischen Rhintis. Eine Wirksamkeits- und Kostenanalyse. Allergologie 26:177–195Google Scholar
  189. 189.
    Lanza DC, Kennedy DW (1992) Current concepts in the surgical management of chronic and recurrent acute sinusitis. J Allergy Clin Immunol 90:505–510 (discussion 511)PubMedCrossRefGoogle Scholar
  190. 190.
    Larsen PL, Tingsgaard PK, Harcourt J et al (1998) Nasal polyps and their relation to polyps/hypertrophic polypoid mucosa in the paranasal sinuses: a macro-, endo-, and microscopic study of autopsy materials. Am J Rhinol 12:45–51PubMedCrossRefGoogle Scholar
  191. 191.
    Larsen PL, Tos M (1991) Origin of nasal polyps. Laryngoscope 101:305–312PubMedCrossRefGoogle Scholar
  192. 192.
    Lee JY, Byun JY (2008) Relationship between the frequency of postoperative debridement and patient discomfort, healing period, surgical outcomes, and compliance after endoscopic sinus surgery. Laryngoscope 118:1868–1872PubMedCrossRefGoogle Scholar
  193. 193.
    Lee JY, Lee SH, Hong HS et al (2008) Is the canine fossa puncture approach really necessary for the severely diseased maxillary sinus during endoscopic sinus surgery? Laryngoscope 118:1082–1087PubMedCrossRefGoogle Scholar
  194. 194.
    Lee JY, Simon RA, Stevenson DD (2007) Selection of aspirin dosages for aspirin desensitization treatment in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol 119:157–164PubMedCrossRefGoogle Scholar
  195. 195.
    Legent F, Bordure P, Beauvillain C et al (1994) A double-blind comparison of ciprofloxacin and amoxycillin/clavulanic acid in the treatment of chronic sinusitis. Chemotherapy 40(Suppl 1):8–15PubMedCrossRefGoogle Scholar
  196. 196.
    Leunig A (2007) Endoskopische Chirurgie der lateralen Nasenwand, der Nasennebenhöhlen und vorderen Schädelbasis. Grundlagen und klinische Beispiele. Endo-Press, TuttlingenGoogle Scholar
  197. 197.
    Leunig A, Braunschweig F, Havel M et al (2009) Bronchospasmus nach ASS-Einnahme. Ist es eine Aspirinintoleranz? MMW Fortschr Med 151:44–45PubMedGoogle Scholar
  198. 198.
    Levine H, Clemente M (2004) Sinus surgery, endoscopic and microscopic approaches. Thieme, StuttgartGoogle Scholar
  199. 199.
    Lewison E (1970) Comparison of the effectiveness of topical and oral nasal decongestants. Eye Ear Nose Throat Mon 49:16–18PubMedGoogle Scholar
  200. 200.
    Leynaert B, Neukirch F, Demoly P et al (2000) Epidemiologic evidence for asthma and rhinitis comorbidity. J Allergy Clin Immunol 106:201–205CrossRefGoogle Scholar
  201. 201.
    Liang X, Jacobs R, Hassan B et al (2009) A comparative evaluation of Cone Beam Computed Tomography (CBCT) and Multi-Slice CT (MSCT) Part I. On subjective image quality. Eur J Radiol 75:265–269PubMedCrossRefGoogle Scholar
  202. 202.
    Liang X, Lambrichts I, Sun Y et al (2009) A comparative evaluation of Cone Beam Computed Tomography (CBCT) and Multi-Slice CT (MSCT). Part II: On 3D model accuracy. Eur J Radiol 75:270–274PubMedCrossRefGoogle Scholar
  203. 203.
    Lildholdt T, Rundcrantz H, Bende M et al (1997) Glucocorticoid treatment for nasal polyps. The use of topical budesonide powder, intramuscular betamethasone, and surgical treatment. Arch Otolaryngol Head Neck Surg 123:595–600PubMedCrossRefGoogle Scholar
  204. 204.
    Lildholdt T, Rundcrantz H, Lindqvist N (1995) Efficacy of topical corticosteroid powder for nasal polyps: a double-blind, placebo-controlled study of budesonide. Clin Otolaryngol Allied Sci 20:26–30PubMedCrossRefGoogle Scholar
  205. 205.
    Lim M, Citardi MJ, Leong JL (2008) Topical antimicrobials in the management of chronic rhinosinusitis: a systematic review. Am J Rhinol 22:381–389PubMedCrossRefGoogle Scholar
  206. 206.
    Lindbaek M, Hjortdahl P, Johnsen UL (1996) Use of symptoms, signs, and blood tests to diagnose acute sinus infections in primary care: comparison with computed tomography. Fam Med 28:183–188PubMedGoogle Scholar
  207. 207.
    Ling FT, Kountakis SE (2007) Important clinical symptoms in patients undergoing functional endoscopic sinus surgery for chronic rhinosinusitis. Laryngoscope 117:1090–1093PubMedCrossRefGoogle Scholar
  208. 208.
    Low DE, Desrosiers M, McSherry J et al (1997) A practical guide for the diagnosis and treatment of acute sinusitis. CMAJ 156(Suppl 6):1–14Google Scholar
  209. 209.
    Lund VJ (2001) Evidence-based surgery in chronic rhinosinusitis. Acta Otolaryngol 121:5–9PubMedCrossRefGoogle Scholar
  210. 210.
    Lund VJ, Flood J, Sykes AP et al (1998) Effect of fluticasone in severe polyposis. Arch Otolaryngol Head Neck Surg 124:513–518PubMedGoogle Scholar
  211. 211.
    Lund VJ, Kennedy DW (1997) Staging for rhinosinusitis. Otolaryngol Head Neck Surg 117:35–40CrossRefGoogle Scholar
  212. 212.
    Lundeberg T, Laurell G, Thomas M (1988) Effect of acupuncture on sinus pain and experimentally induced pain. Ear Nose Throat J 67:565–566, 571–572, 574–575PubMedGoogle Scholar
  213. 213.
    Macdonald KI, McNally JD, Massoud E (2009) The health and resource utilization of Canadians with chronic rhinosinusitis. Laryngoscope 119:184–189PubMedCrossRefGoogle Scholar
  214. 214.
    Marple BF, Stankiewicz JA, Baroody FM et al (2009) Diagnosis and management of chronic rhinosinusitis in adults. Postgrad Med 121:121–139PubMedCrossRefGoogle Scholar
  215. 215.
    Marshall I (2000) Zinc for the common cold. Cochrane Database Syst Rev:CD001364Google Scholar
  216. 216.
    Matsui T, Arai H, Nakajo M et al (2003) Role of chronic sinusitis in cognitive functioning in the elderly. J Am Geriatr Soc 51:1818–1819PubMedCrossRefGoogle Scholar
  217. 217.
    McAlister WH, Lusk R, Muntz HR (1989) Comparison of plain radiographs and coronal CT scans in infants and children with recurrent sinusitis. AJR Am J Roentgenol 153:1259–1264PubMedGoogle Scholar
  218. 218.
    McCormick DP, John SD, Swischuk LE et al (1996) A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children. Clin Pediatr (Phila) 35:457–460Google Scholar
  219. 219.
    McMains KC (2008) Safety in endoscopic sinus surgery. Curr Opin Otolaryngol Head Neck Surg 16:247–251PubMedCrossRefGoogle Scholar
  220. 220.
    Melchart D, Linde K, Fischer P et al (2000) Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev:CD000530Google Scholar
  221. 221.
    Melroy CT, Kuhn FA (2009) Safety of ethmoid sinus drug-eluting catheter insertion. Ann Otol Rhinol Laryngol 118:708–713PubMedGoogle Scholar
  222. 222.
    Meltzer EO, Charous BL, Busse WW et al (2000) Added relief in the treatment of acute recurrent sinusitis with adjunctive mometasone furoate nasal spray. The Nasonex Sinusitis Group. J Allergy Clin Immunol 106:630–637PubMedCrossRefGoogle Scholar
  223. 223.
    Meltzer EO, Hamilos DL, Hadley JA et al (2004) Rhinosinusitis: Establishing definitions for clinical research and patient care. Otolaryngol Head Neck Surg 131:1–62CrossRefGoogle Scholar
  224. 224.
    Meltzer EO, Orgel HA, Backhaus JW et al (1993) Intranasal flunisolide spray as an adjunct to oral antibiotic therapy for sinusitis. J Allergy Clin Immunol 92:812–823 (EL Ib)PubMedCrossRefGoogle Scholar
  225. 225.
    Milewski M, Mastalerz L, Nizankowska E et al (1998) Nasal provocation test with lysine-aspirin for diagnosis of aspirin-sensitive asthma. J Allergy Clin Immunol 101:581–586PubMedCrossRefGoogle Scholar
  226. 226.
    Min YG, Jung HW, Kim HS et al (1996) Prevalence and risk factors of chronic sinusitis in Korea: results of a nationwide survey. Eur Arch Otorhinolaryngol 253:435–439PubMedCrossRefGoogle Scholar
  227. 227.
    Mosges R, Spaeth J, Berger K et al (2002) Topical treatment of rhinosinusitis with fusafungine nasal spray. A double-blind, placebo-controlled, parallel-group study in 20 patients. Arzneimittelforschung 52:877–883PubMedGoogle Scholar
  228. 228.
    Muntz HR, Lusk RP (1991) Bacteriology of the ethmoid bullae in children with chronic sinusitis. Arch Otolaryngol Head Neck Surg 117:179–181PubMedCrossRefGoogle Scholar
  229. 229.
    Murphy MP, Fishman P, Short SO et al (2002) Health care utilization and cost among adults with chronic rhinosinusitis enrolled in a health maintenance organization. Otolaryngol Head Neck Surg 127:367–376PubMedCrossRefGoogle Scholar
  230. 230.
    Mygind N, Dahl R, Nielsen LP et al (1997) Effect of corticosteroids on nasal blockage in rhinitis measured by objective methods. Allergy 52:39–44PubMedCrossRefGoogle Scholar
  231. 231.
    Namyslowski G, Misiolek M, Czecior E et al (2002) Comparison of the efficacy and tolerability of amoxycillin/clavulanic acid 875 mg b.i.d. with cefuroxime 500 mg b.i.d. in the treatment of chronic and acute exacerbation of chronic sinusitis in adults. J Chemother 14:508–517PubMedGoogle Scholar
  232. 232.
    Nayak AS, Settipane GA, Pedinoff A et al (2002) Effective dose range of mometasone furoate nasal spray in the treatment of acute rhinosinusitis. Ann Allergy Asthma Immunol 89:271–278PubMedCrossRefGoogle Scholar
  233. 233.
    Neubauer N, März R (1994) Placebo-controlled, randomized double-blind clinical trial with Sinupret sugar-coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1:177–181CrossRefGoogle Scholar
  234. 234.
    Nilssen EL, Wardrop P, El-Hakim H et al (2002) A randomized control trial of post-operative care following endoscopic sinus surgery: debridement versus no debridement. J Laryngol Otol 116:108–111PubMedCrossRefGoogle Scholar
  235. 235.
    Nizankowska-Mogilnicka E, Bochenek G, Mastalerz L et al (2007) EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity. Allergy 62:1111–1118PubMedCrossRefGoogle Scholar
  236. 236.
    Nizankowska E, Duplaga M, Bochenek G et al (1998) Clinical course of aspirin induced asthma: results of AIANE. In: Szczecklik A, Gryglewski RJ (eds) Eicosanoids, aspirin and asthma. Marcel Dekker, New York, p 451–471Google Scholar
  237. 237.
    O’Hara J, Jones NS (2006) „Post-nasal drip syndrome“: most patients with purulent nasal secretions do not complain of chronic cough. Rhinology 44:270–273Google Scholar
  238. 238.
    Ophir D, Elad Y (1987) Effects of steam inhalation on nasal patency and nasal symptoms in patients with the common cold. Am J Otolaryngol 8:149–153PubMedCrossRefGoogle Scholar
  239. 239.
    Orobello PW Jr, Park RI, Belcher LJ et al (1991) Microbiology of chronic sinusitis in children. Arch Otolaryngol Head Neck Surg 117:980–983PubMedCrossRefGoogle Scholar
  240. 240.
    Padberg J, Bauer T (2006) Erkältungskrankheiten. Dtsch Med Wochenschr 131:2341–2349 (quiz 2351–2342)PubMedCrossRefGoogle Scholar
  241. 241.
    Pang YT, Willatt DJ (1996) Do antral washouts have a place in the current management of chronic sinusitis? J Laryngol Otol 110:926–928PubMedGoogle Scholar
  242. 242.
    Pant H, Ferguson BJ, Macardle PJ (2009) The role of allergy in rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 17:232–238PubMedCrossRefGoogle Scholar
  243. 243.
    Parikh AA, Scadding GK (2005) Intranasal lysine-aspirin in aspirin-sensitive nasal polyposis: a controlled trial. Laryngoscope 115:1385–1390PubMedCrossRefGoogle Scholar
  244. 244.
    Patou J, Gevaert P, Van Zele T et al (2008) Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps. J Allergy Clin Immunol 121:110–115PubMedCrossRefGoogle Scholar
  245. 245.
    Patriarca G, Bellioni P, Nucera E et al (1991) Intranasal treatment with lysine acetylsalicylate in patients with nasal polyposis. Ann Allergy 67:588–592PubMedGoogle Scholar
  246. 246.
    Pawankar R, Zernotti ME (2009) Rhinosinusitis in children and asthma severity. Curr Opin Allergy Clin Immunol 9:151–153PubMedGoogle Scholar
  247. 247.
    Pearlman AN, Conley DB (2008) Review of current guidelines related to the diagnosis and treatment of rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 16:226–230PubMedCrossRefGoogle Scholar
  248. 248.
    Pelikan Z (2009) Diagnostic value of nasal allergen challenge combined with radiography and ultrasonography in chronic maxillary sinus disease. Arch Otolaryngol Head Neck Surg 135:1246–1255PubMedCrossRefGoogle Scholar
  249. 249.
    Penttila M, Poulsen P, Hollingworth K et al (2000) Dose-related efficacy and tolerability of fluticasone propionate nasal drops 400 μg once daily and twice daily in the treatment of bilateral nasal polyposis: a placebo-controlled randomized study in adult patients. Clin Exp Allergy 30:94–102PubMedCrossRefGoogle Scholar
  250. 250.
    Pfaar O, Klimek L (2006) Aspirin desensitization in aspirin intolerance: update on current standards and recent improvements. Curr Opin Allergy Clin Immunol 6:161–166PubMedGoogle Scholar
  251. 251.
    Pfaar O, Klimek L (2006) Eicosanoids, aspirin-intolerance and the upper airways – current standards and recent improvements of the desensitization therapy. J Physiol Pharmacol 57(Suppl 12):5–13PubMedGoogle Scholar
  252. 252.
    Pfaar O, Spielhaupter M, Wrede H et al (2006) Adaptive Desaktivierung bei ASS-intoleranten Patienten mit Polyposis nasi et sinuum. Allergologie 29:322–332Google Scholar
  253. 253.
    Piccirillo JF, Mager DE, Frisse ME et al (2001) Impact of first-line vs second-line antibiotics for the treatment of acute uncomplicated sinusitis. JAMA 286:1849–1856PubMedCrossRefGoogle Scholar
  254. 254.
    Pleis JR, Coles R (2002) Summary health statistics for U.S. adults: National Health Interview Survey, 1998. Vital Health Stat 10:1–113Google Scholar
  255. 255.
    Poetker DM, Litvack JR, Mace JC et al (2008) Recurrent acute rhinosinusitis: presentation and outcomes of sinus surgery. Am J Rhinol 22:329–333PubMedCrossRefGoogle Scholar
  256. 256.
    Ponikau JU, Sherris DA, Kern EB et al (1999) The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 74:877–884PubMedCrossRefGoogle Scholar
  257. 257.
    Ponikau JU, Sherris DA, Weaver A et al (2005) Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol 115:125–131PubMedCrossRefGoogle Scholar
  258. 258.
    Prince AA, Steiger JD, Khalid AN et al (2008) Prevalence of biofilm-forming bacteria in chronic rhinosinusitis. Am J Rhinol 22:239–245PubMedCrossRefGoogle Scholar
  259. 259.
    Rabago D, Zgierska A, Mundt M et al (2002) Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J Fam Pract 51:1049–1055PubMedGoogle Scholar
  260. 260.
    Ragab SM, Lund VJ, Scadding G (2004) Evaluation of the medical and surgical treatment of chronic rhinosinusitis: a prospective, randomised, controlled trial. Laryngoscope 114:923–930PubMedCrossRefGoogle Scholar
  261. 261.
    Ramadan HH (1995) What is the bacteriology of chronic sinusitis in adults? Am J Otolaryngol 16:303–306PubMedCrossRefGoogle Scholar
  262. 262.
    Ramadan HH, McLaughlin K, Josephson G et al (2010) Balloon catheter sinuplasty in young children. Am J Rhinol Allergy 24:e54–e56PubMedCrossRefGoogle Scholar
  263. 263.
    Rasp G (2010) Is there a role for leukotriene antagonists in the prevention of recurrent nasal polyps? Curr Opin Allergy Clin Immunol 10:200–205PubMedCrossRefGoogle Scholar
  264. 264.
    Rasp G, Kramer MF, Ostertag P et al (2000) Ein neues System zur Einteilung der Siebbeinpolyposis. Einfluss einer kombinierten lokalen und systemischen Steroidtherapie. Laryngorhinootologie 79:266–272PubMedCrossRefGoogle Scholar
  265. 265.
    Rawlings BA, Han JK (2010) Level of complete dissection of the ethmoid sinuses with a computed tomographic image guidance system. Ann Otol Rhinol Laryngol 119:17–21PubMedGoogle Scholar
  266. 266.
    Ray NF, Baraniuk JN, Thamer M et al (1999) Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders. J Allergy Clin Immunol 103:408–414PubMedCrossRefGoogle Scholar
  267. 267.
    Reardon EJ (2002) Navigational risks associated with sinus surgery and the clinical effects of implementing a navigational system for sinus surgery. Laryngoscope 112:1–19PubMedCrossRefGoogle Scholar
  268. 268.
    Rice D, Schaefer S (2004) Endoscopic paranasal sinus surgery. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  269. 269.
    Rohr AS, Spector SL, Siegel SC et al (1986) Correlation between A-mode ultrasound and radiography in the diagnosis of maxillary sinusitis. J Allergy Clin Immunol 78:58–61PubMedCrossRefGoogle Scholar
  270. 270.
    Rosbe KW, Jones KR (1998) Usefulness of patient symptoms and nasal endoscopy in the diagnosis of chronic sinusitis. Am J Rhinol 12:167–171PubMedCrossRefGoogle Scholar
  271. 271.
    Roseler S, Holtappels G, Wagenmann M et al (1995) Elevated levels of interleukins IL-1 beta, IL-6 and IL-8 in naturally acquired viral rhinitis. Eur Arch Otorhinolaryngol 252(Suppl 1):61–63CrossRefGoogle Scholar
  272. 272.
    Rosenfeld RM (2007) Clinical practice guideline on adult sinusitis. Otolaryngol Head Neck Surg 137:365–377PubMedCrossRefGoogle Scholar
  273. 273.
    Rosenfeld RM, Andes D, Bhattacharyya N et al (2007) Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg 137:1–31PubMedCrossRefGoogle Scholar
  274. 274.
    Rosenfeld RM, Singer M, Jones S (2007) Systematic review of antimicrobial therapy in patients with acute rhinosinusitis. Otolaryngol Head Neck Surg 137:32–45CrossRefGoogle Scholar
  275. 275.
    Rossberg E, Larsson PG, Birkeflet O et al (2005) Comparison of traditional Chinese acupuncture, minimal acupuncture at non-acupoints and conventional treatment for chronic sinusitis. Complement Ther Med 13:4–10PubMedCrossRefGoogle Scholar
  276. 276.
    Rudack C, Hauser U, Wagenmann M et al (1998) Zytokinmuster bei verschiedenen Formen der Nasennebenhöhlenentzündungen. Laryngorhinootologie 77:34–37PubMedCrossRefGoogle Scholar
  277. 277.
    Rudack C, Stoll W, Bachert C (1998) Cytokines in nasal polyposis, acute and chronic sinusitis. Am J Rhinol 12:383–388PubMedCrossRefGoogle Scholar
  278. 278.
    Ruhno J, Andersson B, Denburg J et al (1990) A double-blind comparison of intranasal budesonide with placebo for nasal polyposis. J Allergy Clin Immunol 86:946–953PubMedCrossRefGoogle Scholar
  279. 279.
    Samter M, Beers RF Jr (1968) Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Ann Intern Med 68:975–983PubMedGoogle Scholar
  280. 280.
    Sauer M, Lemmens W, Vauterin T et al (2007) Comparing the microdebrider and standard instruments in endoscopic sinus surgery: a double-blind randomised study. B-ENT 3:1–7Google Scholar
  281. 281.
    Savolainen S, Jousimies-Somer H, Kleemola M et al (1989) Serological evidence of viral or Mycoplasma pneumoniae infection in acute maxillary sinusitis. Eur J Clin Microbiol Infect Dis 8:131–135PubMedCrossRefGoogle Scholar
  282. 282.
    Savvateeva DM, Guldner C, Murthum T et al (2010) Digital volume tomography (DVT) measurements of the olfactory cleft and olfactory fossa. Acta Otolaryngol 130:398–404PubMedCrossRefGoogle Scholar
  283. 283.
    Schmitz-Schumann M, Schaub E, Virchow C (1982) Inhalative Provokation mit Lysin-Azetylsalizylsäure bei Analgetika-Asthma-Syndrom. Prax Klin Pneumol 36:17–21PubMedGoogle Scholar
  284. 284.
    Seiberling K, Jardeleza C, Wormald PJ (2009) Minitrephination of the frontal sinus: indications and uses in today’s era of sinus surgery. Am J Rhinol Allergy 23:229–231PubMedCrossRefGoogle Scholar
  285. 285.
    Seiberling K, Ooi E, MiinYip J et al (2009) Canine fossa trephine for the severely diseased maxillary sinus. Am J Rhinol Allergy 23:615–618PubMedCrossRefGoogle Scholar
  286. 286.
    Selivanova O, Kuehnemund M, Mann WJ et al (2003) Comparison of conventional instruments and mechanical debriders for surgery of patients with chronic sinusitis. Am J Rhinol 17:197–202PubMedGoogle Scholar
  287. 287.
    Seltzer AP (1967) Adjunctive use of bromelains in sinusitis: a controlled study. Eye Ear Nose Throat Mon 46:1281–1288PubMedGoogle Scholar
  288. 288.
    Senior BA, Kennedy DW, Tanabodee J et al (1998) Long-term results of functional endoscopic sinus surgery. Laryngoscope 108:151–157PubMedCrossRefGoogle Scholar
  289. 289.
    Setliff RC 3rd (1996) Minimally invasive sinus surgery: the rationale and the technique. Otolaryngol Clin North Am 29:115–124PubMedGoogle Scholar
  290. 290.
    Settipane GA (1996) Nasal polyps and immunoglobulin E (IgE). Allergy Asthma Proc 17:269–273PubMedCrossRefGoogle Scholar
  291. 291.
    Shapiro GG, Furukawa CT, Pierson WE et al (1986) Blinded comparison of maxillary sinus radiography and ultrasound for diagnosis of sinusitis. J Allergy Clin Immunol 77:59–64PubMedCrossRefGoogle Scholar
  292. 292.
    Shashy RG, Moore EJ, Weaver A (2004) Prevalence of the chronic sinusitis diagnosis in Olmsted County, Minnesota. Arch Otolaryngol Head Neck Surg 130:320–323PubMedCrossRefGoogle Scholar
  293. 293.
    Simasek M, Blandino DA (2007) Treatment of the common cold. Am Fam Physician 75:515–520PubMedGoogle Scholar
  294. 294.
    Simmen D, Jones N (2005) Chirurgie der Nasennebenhöhlen und der vorderen Schädelbasis. Thieme, StuttgartGoogle Scholar
  295. 295.
    Sindwani R (2008) Image-guided surgery of the paranasal sinuses and skull base. Mo Med 105:257–261PubMedGoogle Scholar
  296. 296.
    Smith TL, Batra PS, Seiden AM et al (2005) Evidence supporting endoscopic sinus surgery in the management of adult chronic rhinosinusitis: a systematic review. Am J Rhinol 19:537–543PubMedGoogle Scholar
  297. 297.
    Smith TL, Stewart MG, Orlandi RR et al (2007) Indications for image-guided sinus surgery: the current evidence. Am J Rhinol 21:80–83PubMedCrossRefGoogle Scholar
  298. 298.
    Smith WM, Davidson TM, Murphy C (2009) Regional variations in chronic rhinosinusitis, 2003–2006. Otolaryngol Head Neck Surg 141:347–352PubMedCrossRefGoogle Scholar
  299. 299.
    Soler ZM, Mace J, Smith TL (2008) Symptom-based presentation of chronic rhinosinusitis and symptom-specific outcomes after endoscopic sinus surgery. Am J Rhinol 22:297–301PubMedCrossRefGoogle Scholar
  300. 300.
    Soyka MB, Holzmann D (2005) Correlation of complications during endoscopic sinus surgery with surgeon skill level and extent of surgery. Am J Rhinol 19:274–281PubMedGoogle Scholar
  301. 301.
    Spector SL, Bernstein IL, Li JT et al (1998) Parameters for the diagnosis and management of sinusitis. J Allergy Clin Immunol 102:107–144CrossRefGoogle Scholar
  302. 302.
    Stamm A, Draf W (2000) Micro-endoscopic surgery of the paranasal sinuses and the skull base. Springer, BerlinGoogle Scholar
  303. 303.
    Stammberger H (1991) Functional endoscopic sinus surgery. The Messerklinger Technique. BC Decker, PhiladelphiaGoogle Scholar
  304. 304.
    Stankiewicz J (1997) Chronic sinusitis. In: Johnson J, Yu V (eds) Infectious Deseases and Antimicrobial Therapy of the Ears, Nose and Throat. W.B. Saunders Company, Philadelphia, p 350–360Google Scholar
  305. 305.
    Stankiewicz JA (1989) Complications in endoscopic intranasal ethmoidectomy: an update. Laryngoscope 99:686–690PubMedGoogle Scholar
  306. 306.
    Stankiewicz JA, Chow JM (2002) A diagnostic dilemma for chronic rhinosinusitis: definition accuracy and validity. Am J Rhinol 16:199–202PubMedGoogle Scholar
  307. 307.
    Stevenson DD (2009) Aspirin sensitivity and desensitization for asthma and sinusitis. Curr Allergy Asthma Rep 9:155–163PubMedCrossRefGoogle Scholar
  308. 308.
    Stevenson DD, Hankammer MA, Mathison DA et al (1996) Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: long-term outcomes. J Allergy Clin Immunol 98:751–758PubMedCrossRefGoogle Scholar
  309. 309.
    Stevenson DD, Pleskow WW, Simon RA et al (1984) Aspirin-sensitive rhinosinusitis asthma: a double-blind crossover study of treatment with aspirin. J Allergy Clin Immunol 73:500–507PubMedCrossRefGoogle Scholar
  310. 310.
    Stevenson DD, Simon RA, Mathison DA (1980) Aspirin-sensitive asthma: tolerance to aspirin after positive oral aspirin challenges. J Allergy Clin Immunol 66:82–88PubMedCrossRefGoogle Scholar
  311. 311.
    Strauss G (2009) Computerassistierte Chirurgie an der Rhinobasis. HNO 57:990–997PubMedCrossRefGoogle Scholar
  312. 312.
    Strauss G, Hofer M, Korb W et al (2006) Genauigkeit und Präzision in der Bewertung von chirurgischen Navigations- und Assistenzsystemen. Eine Begriffsbestimmung. HNO 54:78–84PubMedCrossRefGoogle Scholar
  313. 313.
    Strauss G, Limpert E, Strauss M et al (2009) Untersuchungen zur Effizienz eines Navigationssystems fur die HNO-Chirurgie: Auswertungen von 300 Patienten. Laryngorhinootologie 88:776–781PubMedCrossRefGoogle Scholar
  314. 314.
    Stuck BA, Bachert C, Federspil P et al (2007) Leitlinie „Rhinosinusitis“ der Deutschen Gesellschaft fur Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. HNO 55:758–760, 762–764, 766–777PubMedCrossRefGoogle Scholar
  315. 315.
    Sweet JM, Stevenson DD, Simon RA et al (1990) Long-term effects of aspirin desensitization – treatment for aspirin-sensitive rhinosinusitis-asthma. J Allergy Clin Immunol 85:59–65PubMedCrossRefGoogle Scholar
  316. 316.
    Szczeklik A, Nizankowska E (2000) Clinical features and diagnosis of aspirin induced asthma. Thorax 55(Suppl 2):42–44CrossRefGoogle Scholar
  317. 317.
    Szczeklik A, Nizankowska E, Duplaga M (2000) Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma. Eur Respir J 16:432–436PubMedCrossRefGoogle Scholar
  318. 318.
    Szczeklik A, Sanak M, Nizankowska-Mogilnicka E et al (2004) Aspirin intolerance and the cyclooxygenase-leukotriene pathways. Curr Opin Pulm Med 10:51–56PubMedCrossRefGoogle Scholar
  319. 319.
    Szczeklik A, Stevenson DD (2003) Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management. J Allergy Clin Immunol 111:913–921 (quiz 922)PubMedCrossRefGoogle Scholar
  320. 320.
    Tabaee A, Hsu AK, Shrime MG et al (2006) Quality of life and complications following image-guided endoscopic sinus surgery. Otolaryngol Head Neck Surg 135:76–80PubMedCrossRefGoogle Scholar
  321. 321.
    Taccariello M, Parikh A, Darby Y et al (1999) Nasal douching as a valuable adjunct in the management of chronic rhinosinusitis. Rhinology 37:29–32PubMedGoogle Scholar
  322. 322.
    Takeuchi H, Jawad MS, Eccles R (1999) The effects of nasal massage of the „yingxiang“ acupuncture point on nasal airway resistance and sensation of nasal airflow in patients with nasal congestion associated with acute upper respiratory tract infection. Am J Rhinol 13:77–79PubMedCrossRefGoogle Scholar
  323. 323.
    Talbot AR, Herr TM, Parsons DS (1997) Mucociliary clearance and buffered hypertonic saline solution. Laryngoscope 107:500–503PubMedCrossRefGoogle Scholar
  324. 324.
    Tan BK, Schleimer RP, Kern RC (2010) Perspectives on the etiology of chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 18:21–26PubMedCrossRefGoogle Scholar
  325. 325.
    Tantilipikorn P, Fritz M, Tanabodee J et al (2002) A comparison of endoscopic culture techniques for chronic rhinosinusitis. Am J Rhinol 16:255–260PubMedGoogle Scholar
  326. 326.
    Taub SJ (1967) The use of bromelains in sinusitis: a double-blind clinical evaluation. Eye Ear Nose Throat Mon 46:361–362 (passim)PubMedGoogle Scholar
  327. 327.
    Brinke A ten, Grootendorst DC, Schmidt JT et al (2002) Chronic sinusitis in severe asthma is related to sputum eosinophilia. J Allergy Clin Immunol 109:621–626PubMedCrossRefGoogle Scholar
  328. 328.
    Tesche S, Metternich F, Sonnemann U et al (2008) The value of herbal medicines in the treatment of acute non-purulent rhinosinusitis. Results of a double-blind, randomised, controlled trial. Eur Arch Otorhinolaryngol 265:1355–1359PubMedCrossRefGoogle Scholar
  329. 329.
    Teul I, Zbislawski W, Baran S et al (2007) Quality of life of patients with diseases of sinuses. J Physiol Pharmacol 58(Suppl 5):691–697PubMedGoogle Scholar
  330. 330.
    Tolsdorff B, Pommert A, Hohne KH et al (2010) Virtual reality: a new paranasal sinus surgery simulator. Laryngoscope 120:420–426PubMedGoogle Scholar
  331. 331.
    Tomooka LT, Murphy C, Davidson TM (2000) Clinical study and literature review of nasal irrigation. Laryngoscope 110:1189–1193PubMedCrossRefGoogle Scholar
  332. 332.
    Tos M, Svendstrup F, Arndal H et al (1998) Efficacy of an aqueous and a powder formulation of nasal budesonide compared in patients with nasal polyps. Am J Rhinol 12:183–189PubMedCrossRefGoogle Scholar
  333. 333.
    Tschopp KP, Thomaser EG (2008) Outcome of functional endonasal sinus surgery with and without CT-navigation. Rhinology 46:116–120PubMedGoogle Scholar
  334. 334.
    Turner BW, Cail WS, Hendley JO et al (1992) Physiologic abnormalities in the paranasal sinuses during experimental rhinovirus colds. J Allergy Clin Immunol 90:474–478PubMedCrossRefGoogle Scholar
  335. 335.
    Tyrrell D, Barrow I, Arthur J (1989) Local hyperthermia benefits natural and experimental common colds. BMJ 298:1280–1283PubMedCrossRefGoogle Scholar
  336. 336.
    Vairaktaris E, Moschos MM, Vassiliou S et al (2009) Orbital cellulitis, orbital subperiosteal and intraorbital abscess: report of three cases and review of the literature. J Craniomaxillofac Surg 37:132–136PubMedCrossRefGoogle Scholar
  337. 337.
    Van Bruaene N, Derycke L, Perez-Novo CA et al (2009) TGF-beta signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol 124:253–259, e251–e252CrossRefGoogle Scholar
  338. 338.
    Van Bruaene N, Perez-Novo CA, Basinski TM et al (2008) T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol 121:1435–1441, e1431–e1433CrossRefGoogle Scholar
  339. 339.
    Buchem L van, Peeters M, Beaumont J et al (1995) Acute maxillary sinusitis in general practice: the relation between clinical picture and objective findings. Eur J Gen Pract 1:155–160CrossRefGoogle Scholar
  340. 340.
    Camp C van, Clement PA (1994) Results of oral steroid treatment in nasal polyposis. Rhinology 32:5–9PubMedGoogle Scholar
  341. 341.
    Van Zele T, Claeys S, Gevaert P et al (2006) Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 61:1280–1289CrossRefGoogle Scholar
  342. 342.
    Van Zele T, Gevaert P, Holtappels G et al (2007) Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy 37:1840–1847CrossRefGoogle Scholar
  343. 343.
    Van Zele T, Gevaert P, Watelet JB et al (2004) Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol 114:981–983CrossRefGoogle Scholar
  344. 344.
    Van Zele T, Vaneechoutte M, Holtappels G et al (2008) Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients. Am J Rhinol 22:223–227CrossRefGoogle Scholar
  345. 345.
    Varonen H, Makela M, Savolainen S et al (2000) Comparison of ultrasound, radiography, and clinical examination in the diagnosis of acute maxillary sinusitis: a systematic review. J Clin Epidemiol 53:940–948PubMedCrossRefGoogle Scholar
  346. 346.
    Vaughan WC (2008) Review of balloon sinuplasty. Curr Opin Otolaryngol Head Neck Surg 16:2–9PubMedCrossRefGoogle Scholar
  347. 347.
    Vauterin T, Poorten VV, Jorissen M (2000) Cutting forceps in functional endoscopic sinus surgery. Acta Otorhinolaryngol Belg 54:29–37PubMedGoogle Scholar
  348. 348.
    Vauterin T, Vander Poorten V, Jorissen M (2006) Long term effects of cutting forceps in endoscopic sinus surgery. Rhinology 44:123–127PubMedGoogle Scholar
  349. 349.
    Vickers AJ, Rees RW, Zollman CE et al (2004) Acupuncture for chronic headache in primary care: large, pragmatic, randomised trial. BMJ 328:744PubMedCrossRefGoogle Scholar
  350. 350.
    Virolainen E, Puhakka H (1980) The effect of intranasal beclomethasone dipropionate on the recurrence of nasal polyps after ethmoidectomy. Rhinology 18:9–18PubMedGoogle Scholar
  351. 351.
    Wagenmann M (2004) Die allergische Pilzsinusitis. In: Schultze-Werninghaus G, Fuchs T, Bachert C, Wahn U (eds) Manuale allergologicum. Dustri, OberhachingGoogle Scholar
  352. 352.
    Wallwork B, Coman W, Mackay-Sim A et al (2006) A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope 116:189–193PubMedCrossRefGoogle Scholar
  353. 353.
    Weber R (2006) Persistierende chronische Sinusitis nach Nasennebenhöhlenoperation. Laryngorhinootologie 85:667–685PubMedCrossRefGoogle Scholar
  354. 354.
    Weber R, Draf W, Keerl R et al (1995) Aspekte zur Stirnhöhlenchirurgie. Teil III: Indikation und Ergebnisse der osteoplastischen Stirnhöhlenoperation. HNO 43:414–420PubMedGoogle Scholar
  355. 355.
    Weber R, Draf W, Kratzsch B et al (2001) Modern concepts of frontal sinus surgery. Laryngoscope 111:137–146PubMedCrossRefGoogle Scholar
  356. 356.
    Weber R, Hosemann W (2010) Nachbehandlung nach endonasaler Nasennebenhöhlenoperation. In: Weber R, Hosemann W (Hrsg) Nachbehandlung nach HNO-Operationen. Giebel, EiterfeldGoogle Scholar
  357. 357.
    Weber R, Keerl R, Hosemann W et al (1998) Komplikationen mit bleibenden Schäden bei endonasalen Nasennebenhöhlenoperationen – häufiger bei erfahrenen Operateuren? Laryngorhinootologie 77:398–401PubMedCrossRefGoogle Scholar
  358. 358.
    Weber R, Keerl R, Huppmann A et al (1996) Der Einfluss der Nachbehandlung auf die Wundheilung nach endonasaler Nasennebenhöhlenoperation. Laryngorhinootologie 75:208–214PubMedCrossRefGoogle Scholar
  359. 359.
    Weiss RL, Church CA, Kuhn FA et al (2008) Long-term outcome analysis of balloon catheter sinusotomy: two-year follow-up. Otolaryngol Head Neck Surg 139:38–46CrossRefGoogle Scholar
  360. 360.
    Welch KC, Stankiewicz JA (2009) A contemporary review of endoscopic sinus surgery: techniques, tools, and outcomes. Laryngoscope 119:2258–2268PubMedCrossRefGoogle Scholar
  361. 361.
    Weschta M, Rimek D, Formanek M et al (2004) Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 113:1122–1128PubMedCrossRefGoogle Scholar
  362. 362.
    West B, Jones NS (2001) Endoscopy-negative, computed tomography-negative facial pain in a nasal clinic. Laryngoscope 111:581–586PubMedCrossRefGoogle Scholar
  363. 363.
    Wiegand M (2008) Endoscopic surgery of the paranasal sinuses and anterior skull base. Thieme, StuttgartGoogle Scholar
  364. 364.
    Wiklund L, Stierna P, Berglund R et al (1994) The efficacy of oxymetazoline administered with a nasal bellows container and combined with oral phenoxymethyl-penicillin in the treatment of acute maxillary sinusitis. Acta Otolaryngol Suppl 515:57–64PubMedCrossRefGoogle Scholar
  365. 365.
    Williams JW Jr, Aguilar C, Cornell J et al (2003) Antibiotics for acute maxillary sinusitis. Cochrane Database Syst Rev:CD000243Google Scholar
  366. 366.
    Williams JW Jr, Simel DL (1993) Does this patient have sinusitis? Diagnosing acute sinusitis by history and physical examination. JAMA 270:1242–1246PubMedCrossRefGoogle Scholar
  367. 367.
    Williams JW Jr, Simel DL, Roberts L et al (1992) Clinical evaluation for sinusitis. Making the diagnosis by history and physical examination. Ann Intern Med 117:705–710PubMedGoogle Scholar
  368. 368.
    Williams JWJ, Aguilar C, Makela M et al (2000) Review: Penicillin V or amoxicillin is better than placebo and equal to non-penicillins for acute maxillary sinusitis. Evid Based Med 5:43 (EL Ia)CrossRefGoogle Scholar
  369. 369.
    Williamson IG, Rumsby K, Benge S et al (2007) Antibiotics and topical nasal steroid for treatment of acute maxillary sinusitis: a randomized controlled trial. JAMA 298:2487–2496PubMedCrossRefGoogle Scholar
  370. 370.
    Winther B, Gwaltney JM, Hendley JO (1990) Respiratory virus infection of monolayer cultures of human nasal epithelial cells. Am Rev Respir Dis 141:839–845PubMedGoogle Scholar
  371. 371.
    Wittkopf ML, Becker SS, Duncavage JA et al (2009) Balloon sinuplasty for the surgical management of immunocompromised and critically ill patients with acute rhinosinusitis. Otolaryngol Head Neck Surg 140:596–598PubMedCrossRefGoogle Scholar
  372. 372.
    Wormald P (2007) Endoscopic Sinus Surgery: Anatomy, Three-dimensional Reconstruction, and Surgical Technique. Thieme, StuttgartGoogle Scholar
  373. 373.
    Wynn R, Har-El G (2004) Recurrence rates after endoscopic sinus surgery for massive sinus polyposis. Laryngoscope 114:811–813PubMedCrossRefGoogle Scholar
  374. 374.
    Young J, De Sutter A, Merenstein D et al (2008) Antibiotics for adults with clinically diagnosed acute rhinosinusitis: a meta-analysis of individual patient data. Lancet 371:908–914PubMedCrossRefGoogle Scholar
  375. 375.
    Zalmanovici A, Yaphe J (2009) Intranasal steroids for acute sinusitis. Cochrane Database Syst Rev:CD005149Google Scholar
  376. 376.
    Zeiss CR, Lockey RF (1976) Refractory period to aspirin in a patient with aspirin-induced asthma. J Allergy Clin Immunol 57:440–448PubMedCrossRefGoogle Scholar
  377. 377.
    Zhang N, Gevaert P, Zele T van et al (2005) An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis. Rhinology 43:162–168PubMedGoogle Scholar
  378. 378.
    Zhang N, Van Zele T, Perez-Novo C et al (2008) Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol 122:961–968PubMedCrossRefGoogle Scholar
  379. 379.
    Zinreich SJ, Kennedy DW, Rosenbaum AE et al (1987) Paranasal sinuses: CT imaging requirements for endoscopic surgery. Radiology 163:769–775PubMedGoogle Scholar
  380. 380.
    Zoumalan RA, Lebowitz RA, Wang E et al (2009) Flat panel cone beam computed tomography of the sinuses. Otolaryngol Head Neck Surg 140:841–844PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • B.A. Stuck
    • 1
  • C. Bachert
    • 2
  • P. Federspil
    • 3
  • W. Hosemann
    • 4
  • L. Klimek
    • 1
    • 5
  • R. Mösges
    • 6
  • O. Pfaar
    • 1
    • 5
  • C. Rudack
    • 7
  • H. Sitter
    • 8
  • M. Wagenmann
    • 9
  • R. Weber
    • 10
  • K. Hörmann
    • 1
  1. 1.Universitäts-HNO-KlinikMannheimDeutschland
  2. 2.Kliniek voor Neus-, Keel- & Oorheelkunde, UZ GentGentBelgien
  3. 3.-Homburg/SaarDeutschland
  4. 4.Klinik und Poliklinik für Hals-, Nasen-, Ohrenkrankheiten, Kopf- und HalschirurgieGreifswaldDeutschland
  5. 5.Zentrum für Rhinologie und AllergologieWiesbadenDeutschland
  6. 6.Institut für Medizinische Statistik, Informatik und Epidemiologie, Universität zu KölnKölnDeutschland
  7. 7.Klinik und Poliklinik für Hals-, Nasen- und OhrenheilkundeMünsterDeutschland
  8. 8.Institut für Chirurgische ForschungMarburgDeutschland
  9. 9.HNO-Klinik, Universitätsklinikum DüsseldorfDüsseldorfDeutschland
  10. 10.Hals-Nasen-Ohrenklinik, Städtisches Klinikum KarlsruheKarlsruheDeutschland

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