Der Hautarzt

, Volume 61, Issue 7, pp 561–566 | Cite as

UV-Strahlung und Pigmentierung

Arylhydrocarbonrezeptor – „a new kid on the block“
Leitthema
First Online:

Zusammenfassung

UV-Strahlung ist der wichtigste Modulator der Hautpigmentierung. In diesem Beitrag berichten wir über neue Studien, die zeigen, dass der Arylhydrocarbonrezeptor, der durch UV-generierte Photoprodukte aktiviert werden kann, einen wesentlichen Teil der UVB-induzierten Pigmentierungsreaktion vermittelt. Dieser neu entdeckte Mechanismus eröffnet interessante Möglichkeiten, Pigmentstörungen kosmetisch oder therapeutisch zu beeinflussen.

Schlüsselwörter

Arylhydrocarbonrezeptor Melanozyten Differenzierung Umwelt UV-Strahlung 

UV radiation and skin pigmentation

Aryl hydrocarbon receptor – a “new kid on the block”

Abstract

UV radiation is the most important modulator of skin pigmentation. In this article we report on novel studies which show that the aryl hydrocarbon receptor, which can be activated by UV-generated photoproducts, mediates a substantial part of UVB-induced skin pigmentation reaction. This newly discovered mechanism opens interesting possibilities for cosmetic and therapeutic treatment of pigment disorders.

Keywords

Aryl hydrocarbon receptor Melanocytes Differentiation Environment UV radiation 
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Notes

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Leibniz-Institut für Umweltmedizinische Forschung (IUF) gGmbHHeinrich-Heine-Universität DüsseldorfDüsseldorfDeutschland

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