Der Hautarzt

, Volume 60, Issue 12, pp 956–960 | Cite as

Weizenabhängige anstrengungsinduzierte Anaphylaxie

Kurzkasuistiken

Zusammenfassung

Die weizenabhängige anstrengungsinduzierten Anaphylaxie (WDEIA) ist eine IgE-vermittelte anaphylaktische Reaktion gegenüber Weizen, die bei Sensibilisierten nach Verzehr von weizenmehlhaltigen Produkten auftritt, wenn der Nahrungsaufnahme körperliche Anstrengung folgt. Als Hauptallergen wurde das Weizenprotein Omega(ω)-5-Gliadin (Tri a 19) identifiziert. Wir präsentieren 3 Fallberichte von Patienten, bei denen die Diagnose einer WDEIA durch den Nachweis von spezifischem IgE gegen das rekombinante Protein Tri a 19 gesichert werden konnte.

Schlüsselwörter

Weizen Anstrengung Anaphylaxie Omega-5-Gliadin IgE 

Wheat-dependent, exercise-induced anaphylaxis

Abstract

Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare IgE-dependent anaphylaxis to wheat, which occurs in sensitized people after ingestion of wheat followed by physical exercise. The major allergen associated with WDEIA is the wheat protein Omega (ω)-5-Gliadin (Tri a 19). We present three cases of WDEIA, demonstrating that this disease might be more frequent than anticipated and that neither prick test nor specific IgE to allergen extracts but rather detection of specific IgE against the recombinant protein Tri a 19 leads to diagnosis.

Keywords

Wheat Exercise Anaphylaxis Omega-5-Gliadin IgE 

Notes

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

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Copyright information

© Springer Medizin Verlag 2009

Authors and Affiliations

  1. 1.Klinik für Allergologie und DermatologieUniversitätsklinikum RWTH AachenAachenDeutschland

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