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Der Hautarzt

, Volume 60, Issue 8, pp 627–632 | Cite as

Dermatitis herpetiformis

Aktuelle Aspekte der Pathogenese
Leitthema

Zusammenfassung

Dieser Beitrag gibt eine detaillierte Übersicht über die multifaktorielle Pathogenese der Dermatitis herpetiformis, basierend auf den aktuellen experimentellen Daten. Eine genetische Veranlagung, eine glutenreiche Diät sowie krankhafte Immun- und Autoimmunreaktionen sind die wichtigsten pathogenetischen Faktoren, aber auch andere können die Erkrankung beeinflussen. Die prädisponierenden und induzierenden Faktoren werden im Beitrag zusammengefasst, und die zu den Hautveränderungen führenden pathophysiologischen Schritte werden ausführlich dargestellt.

Schlüsselwörter

Dermatitis herpetiformis Zöliakie Gewebstransglutaminase Epidermale Transglutaminase Gluten 

Abkürzungen

DH

Dermatitis herpetiformis

GSK

Glutensensitive Krankheit

TG

Transglutaminase

TGc

Gewebstransglutaminase (= TG2)

TGe

Epidermale Transglutaminase (= TG3)

TGy

Transglutaminase y (= TG6)

Dermatitis herpetiformis

An update of the pathogenesis

Abstract

The multifactorial pathogenesis of dermatitis herpetiformis is reviewed in light of current experimental data. Genetic background, gluten consumption, and abnormal immune and autoimmune reactions are the most important pathogenetic factors, but other agents also participate in the disease development. The predisposing and inducing factors are summarized, while the pathophysiological steps leading to the development of skin symptoms are detailed.

Keywords

Dermatitis herpetiformis Coeliac disease Tissue transglutaminase Epidermal transglutaminase Gluten 

Notes

Danksagung

Wir bedanken uns bei Herrn Dr. Michael Flaig für die Anfertigung der Abb. 5.

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

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Copyright information

© Springer Medizin Verlag 2009

Authors and Affiliations

  1. 1.Klinik und Poliklinik für Dermatologie und AllergologieLudwig-Maximilans-Universität MünchenMünchenDeutschland

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