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Literatur-Update zu Staphylococcus-aureus-Ausbrüchen auf neonatologischen Intensivpflegestationen (2010–2013)

Update on outbreaks reported from neonatal intensive care units (2010–203): Staphylococcus aureus

  • Originalien und Übersichten
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Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Aims and scope

Zusammenfassung

Gehäufte Nachweise von S. aureus in klinischen Materialien (abgenommen bei Infektionsverdacht) und in Abstrichen zur mikrobiologischen Surveillance müssen in neonatologischen Intensivpflegestationen (NICUs) aufgrund der besonderen Patientencharakteristika, des klinischen Bildes und der hohen Pathogenität dieses Erregers bei Frühgeborenen separat von Ausbrüchen in anderen Intensivstationen betrachtet werden. Zur Verbesserung des Ausbruchsmanagements und der Prävention ist es sinnvoll, die aktuelle Literatur zu Ausbrüchen in NICUs für S. aureus inklusive MRSA regelmäßig zu analysieren. Der hier vorgelegte Beitrag aktualisiert und erweitert eine 2007 publizierte Übersicht von Gastmeier et al. und analysiert NICU-Ausbrüche durch S. aureus sowie deren Kontrolle.

Abstract

In terms of the unique risk profile of the patients and the morbidity associated with S. aureus infections in this vulnerable patient population, the literature on outbreaks of S. aureus (including MRSA) in neonatal intensive care units (NICUs) needs to be analyzed separately from reports derived from other intensive care units. With the objective of updating important information for those involved in outbreak management and fostering preventive efforts, this article summarizes the results of a systematic literature analysis, referring to an earlier publication by Gastmeier et al. It focuses on NICU outbreaks caused by S. aureus (including MRSA) and on controlling them.

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Notes

  1. Beim Känguruing wird das Kind direkt auf die Brust der Mutter oder des Vaters gelegt.

  2. caMRSA gehören in der Regel zu den SCCmec Typen IV, und seltener auch V.

  3. http://www.nrz-hygiene.de/surveillance/kiss/hand-kiss/ Der Median der NICU-Referenzdaten lag 2013 bei 113 ml = 38 Händedesinfektionen/Patiententag (Mittelwert 45).

  4. Letztendlich bei allen Mitarbeitern erfolgreich, eine Pflegekraft mit atopischer Dermatitis wurde erst nach 3 Dekolonisationszyklen MRSA-negativ.

  5. Anteil der in zeitlichem Kontext des Ausbruchs verstorbenen Kinder, kausaler Zusammenhang mit der Infektion nicht immer eindeutig.

  6. Alle Prozentangaben wurden zur besseren Lesbarkeit auf- oder abgerundet.

  7. Kausaler Zusammenhang nicht immer eindeutig.

  8. n. s. = nicht signifikant.

Literatur

  1. Gastmeier P, Loui A, Stamm-Balderjahn S, Hansen S, Zuschneid I, Sohr D, Behnke M, Obladen M, Vonberg RP, Ruden H (2007) Outbreaks in neonatal intensive care units – they are not like others. Am J Infect Control 35:172–176

    Article  PubMed  Google Scholar 

  2. Adams-Chapman I (2012) Long-term impact of infection on the preterm neonate. Semin Perinatol 36:462–470

    Article  PubMed  Google Scholar 

  3. Gastmeier P (2014) Serratia marcescens: an outbreak experience. Front Microbiol 5:81

    Article  PubMed Central  PubMed  Google Scholar 

  4. Tuffs A (2011) Poor hospital hygiene is blamed for deaths of three babies in Bremen. BMJ 343:d7396

    Article  PubMed  Google Scholar 

  5. Tuffs A (2012) Neonatal ward in Bremen is closed down again after two more deaths of babies. BMJ 344:e1680

    Article  PubMed  Google Scholar 

  6. Gortner L, Borkhardt A, Reiss I (2000) Consequences of scientific reports of complications. Lancet 356:2015

    Article  CAS  PubMed  Google Scholar 

  7. Reiss I, Borkhardt A, Fussle R, Sziegoleit A, Gortner L (2000) Disinfectant contaminated with Klebsiella oxytoca as a source of sepsis in babies. Lancet 356:310

    Article  CAS  PubMed  Google Scholar 

  8. Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (2007) Empfehlung zur Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1500 g. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 50:1265–1303

    Article  Google Scholar 

  9. Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (2012) Ergänzende Empfehlung (2012) zur „Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1.500 g“ (2007). Epid Bull 2:13–15

    Google Scholar 

  10. Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (2013) Praktische Umsetzung sowie krankenhaushygienische und infektionspräventive Konsequenzen des mikrobiellen Kolonisationsscreenings bei intensivmedizinisch behandelten Früh- und Neugeborenen -Ergänzende Empfehlung der KRINKO beim Robert Koch-Institut, Berlin, zur Implementierung der Empfehlungen zur Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1.500 g aus dem Jahr 2007 und 2012. Epid Bull 42:421–433

    Google Scholar 

  11. Simon A, Tenenbaum T (2013) Surveillance of multidrug-resistant gram-negative pathogens in high-risk neonates-does it make a difference? Pediatr Infect Dis J 32:407–409

    Article  PubMed  Google Scholar 

  12. Christoph J, Dame C, Eckmanns T, Gärtner B, Geffers C, Gille C, Haertel C, Haller S, Hartl D, Kraus-Haas M, Marschal M, Müller A, von Müller L, Simon A (2013) Risikocharakterisierung intensivmedizinisch behandelter Früh- und Neugeborener und Daten zur Ist-Situation in deutschen neonatologischen Intensivpflegestationen 2013 – Fachliche Erläuterungen zu folgender Empfehlung: Praktische Umsetzung sowie krankenhaushygienische und infektionspräventive Konsequenzen des mikrobiellen Kolonisationsscreenings bei intensivmedizinisch behandelten Früh- und Neugeborenen Ergänzende Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut, Berlin zur Implementierung der Empfehlungen zur Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1500 g aus dem Jahr 2007 und 2012. Epid Bull 42 (Suppl)

  13. Gerber SI, Jones RC, Scott MV, Price JS, Dworkin MS, Filippell MB, Rearick T, Pur SL, McAuley JB, Lavin MA, Welbel SF, Garcia-Houchins S, Bova JL, Weber SG, Arnow PM, Englund JA, Gavin PJ, Fisher AG, Thomson RB, Vescio T, Chou T, Johnson DC, Fry MB, Molloy AH, Bardowski L, Noskin GA (2006) Management of outbreaks of methicillin-resistant staphylococcus aureus infection in the neonatal intensive care unit: a consensus statement. Infect Control Hosp Epidemiol 27:139–145

    Article  PubMed  Google Scholar 

  14. Heinrich N, Mueller A, Bartmann P, Simon A, Bierbaum G, Engelhart S (2011) Successful management of an MRSA outbreak in a neonatal intensive care unit. Eur J Clin Microbiol Infect Dis 30:909–913

    Article  CAS  PubMed  Google Scholar 

  15. Scheithauer S, Trepels-Kottek S, Hafner H, Keller D, Ittel T, Wagner N, Heimann K, Schoberer M, Schwarz R, Haase G, Waitschies B, Orlikowsky T, Lemmen S (2014) Healthcare worker-related MRSA cluster in a German neonatology level III ICU: a true European story. Int J Hyg Environ Health 217:307–311

    Article  CAS  PubMed  Google Scholar 

  16. Carey AJ, Della-Latta P, Huard R, Wu F, Graham PL 3rd, Carp D, Saiman L (2010) Changes in the molecular epidemiological characteristics of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Infect Control Hosp Epidemiol 31:613–619

    Article  PubMed  Google Scholar 

  17. Grub C, Holberg-Petersen M, Medbo S, Andersen BM, Syversen G, Melby KK (2010) A multidrug-resistant, methicillin-susceptible strain of Staphylococcus aureus from a neonatal intensive care unit in Oslo, Norway. Scand J Infect Dis 42:148–151

    Article  PubMed  Google Scholar 

  18. Mongkolrattanothai K, Mankin P, Cranston J, Gray BM (2010) Molecular surveillance of Staphylococcus aureus colonization in a neonatal intensive care unit. Am J Infect Control 38:660–663

    Article  PubMed  Google Scholar 

  19. Murillo JL, Cohen M, Kreiswirth B (2010) Results of nasal screening for methicillin-resistant Staphylococcus aureus during a neonatal intensive care unit outbreak. Am J Perinatol 27:79–81

    Article  PubMed  Google Scholar 

  20. Schlebusch S, Price GR, Hinds S, Nourse C, Schooneveldt JM, Tilse MH, Liley HG, Wallis T, Bowling F, Venter D, Nimmo GR (2010) First outbreak of PVL-positive nonmultiresistant MRSA in a neonatal ICU in Australia: comparison of MALDI-TOF and SNP-plus-binary gene typing. Eur J Clin Microbiol Infect Dis 29:1311–1314

    Article  CAS  PubMed  Google Scholar 

  21. Song X, Cheung S, Klontz K, Short B, Campos J, Singh N (2010) A stepwise approach to control an outbreak and ongoing transmission of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Am J Infect Control 38:607–611

    Article  PubMed  Google Scholar 

  22. Ali H, Nash JQ, Kearns AM, Pichon B, Vasu V, Nixon Z, Burgess A, Weston D, Sedgwick J, Ashford G, Muhlschlegel FA (2012) Outbreak of a South West Pacific clone Panton-Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus infection in a UK neonatal intensive care unit. J Hosp Infect 80:293–298

    Article  CAS  PubMed  Google Scholar 

  23. Giuffre M, Cipolla D, Bonura C, Geraci DM, Aleo A, Di Noto S, Nociforo F, Corsello G, Mammina C (2012) Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy. BMC Pediatr 12:64

    Article  PubMed Central  PubMed  Google Scholar 

  24. Koser CU, Holden MT, Ellington MJ, Cartwright EJ, Brown NM, Ogilvy-Stuart AL, Hsu LY, Chewapreecha C, Croucher NJ, Harris SR, Sanders M, Enright MC, Dougan G, Bentley SD, Parkhill J, Fraser LJ, Betley JR, Schulz-Trieglaff OB, Smith GP, Peacock SJ (2012) Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak. N Engl J Med 366:2267–2275

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Nubel U, Nachtnebel M, Falkenhorst G, Benzler J, Hecht J, Kube M, Brocker F, Moelling K, Buhrer C, Gastmeier P, Piening B, Behnke M, Dehnert M, Layer F, Witte W, Eckmanns T (2013) MRSA transmission on a neonatal intensive care unit: epidemiological and genome-based phylogenetic analyses. PLoS ONE 8:e54898

    Article  PubMed Central  PubMed  Google Scholar 

  26. Layer F, Werner G, Cuny C, Strommenger B (2013) Eigenschaften, Häufigkeit und Verbreitung von MRSA in Deutschland – Update 2011/2012. Epid Bull 21:187–193

    Google Scholar 

  27. D'Souza N, Rodrigues C, Mehta A (2010) Molecular characterization of methicillin-resistant Staphylococcus aureus with emergence of epidemic clones of sequence type (ST) 22 and ST 772 in Mumbai, India. J Clin Microbiol 48:1806–1811

    Article  PubMed Central  PubMed  Google Scholar 

  28. Brennan GI, Shore AC, Corcoran S, Tecklenborg S, Coleman DC, O’Connell B (2012) Emergence of hospital- and community-associated panton-valentine leukocidin-positive methicillin-resistant Staphylococcus aureus genotype ST772-MRSA-V in Ireland and detailed investigation of an ST772-MRSA-V cluster in a neonatal intensive care unit. J Clin Microbiol 50:841–847

    Article  PubMed Central  PubMed  Google Scholar 

  29. Scheithauer S, Oude-Aost J, Heimann K, Haefner H, Schwanz T, Waitschies B, Kampf G, Orlikowsky T, Lemmen SW (2011) Hand hygiene in pediatric and neonatal intensive care unit patients: daily opportunities and indication- and profession-specific analyses of compliance. Am J Infect Control 39:732–737

    Article  PubMed  Google Scholar 

  30. Pinto AN, Seth R, Zhou F, Tallon J, Dempsey K, Tracy M, Gilbert GL, O’Sullivan MV (2013) Emergence and control of an outbreak of infections due to Panton-Valentine leukocidin positive, ST22 methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Clin Microbiol Infect 19:620–627

    Article  CAS  PubMed  Google Scholar 

  31. PVL Sub-Group of the Steering Group on Healthcare Associated Infection (2008) Guidance on the diagnosis and management of PVLassociated Staphylococcus aureus infections (PVL-SA) in the UK. Health Protection Agency, London, United Kingdom. http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1218699411960. Zugegriffen: 14. Juni 2013

  32. Grundmann H, Aanensen DM, van den Wijngaard CC, Spratt BG, Harmsen D, Friedrich AW (2010) Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis. PLoS Med 7:e1000215

    Article  PubMed Central  PubMed  Google Scholar 

  33. McAdams RM, Ellis MW, Trevino S, Rajnik M (2008) Spread of methicillin-resistant Staphylococcus aureus USA300 in a neonatal intensive care unit. Pediatr Int 50:810–815

    Article  PubMed  Google Scholar 

  34. Schaumburg F, Kock R, Mellmann A, Richter L, Hasenberg F, Kriegeskorte A, Friedrich AW, Gatermann S, Peters G, von Eiff C, Becker K (2012) Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period. J Clin Microbiol 50:3186–3192

    Article  PubMed Central  PubMed  Google Scholar 

  35. Carey AJ, Duchon J, Della-Latta P, Saiman L (2010) The epidemiology of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit, 2000–2007. J Perinatol 30:135–139

    Article  CAS  PubMed  Google Scholar 

  36. Kuint J, Barzilai A, Regev-Yochay G, Rubinstein E, Keller N, Maayan-Metzger A (2007) Comparison of community-acquired methicillin-resistant Staphylococcus aureus bacteremia to other staphylococcal species in a neonatal intensive care unit. Eur J Pediatr 166:319–325

    Article  PubMed  Google Scholar 

  37. Sax H, Posfay-Barbe K, Harbarth S, Francois P, Touveneau S, Pessoa-Silva CL, Schrenzel J, Dharan S, Gervaix A, Pittet D (2006) Control of a cluster of community-associated, methicillin-resistant Staphylococcus aureus in neonatology. J Hosp Infect 63:93–100

    Article  CAS  PubMed  Google Scholar 

  38. Arbeitsgruppe MRSA der Deutschen Gesellschaft für Pädiatrische Infektiologie und des Paed IC Projektes (2014) Umgang mit MRSA-Nachweisen bei ansonsten gesunden Kindern ohne Infektionszeichen (Neugeborene und ambulantes Betreuungsumfeld). Hygiene Medizin 39:344–357

    Google Scholar 

  39. McAdams RM, Mazuchowski E, Ellis MW, Rajnik M (2005) Necrotizing staphylococcal pneumonia in a neonate. J Perinatol 25:677–679

    Article  PubMed  Google Scholar 

  40. Yee-Guardino S, Kumar D, Abughali N, Tuohy M, Hall GS, Kumar ML (2008) Recognition and treatment of neonatal community-associated MRSA pneumonia and bacteremia. Pediatr Pulmonol 43:203–205

    Article  PubMed  Google Scholar 

  41. Dolapo O, Dhanireddy R, Talati AJ (2014) Trends of Staphylococcus aureus bloodstream infections in a neonatal intensive care unit from 2000–2009. BMC Pediatr 14:121

    Article  PubMed Central  PubMed  Google Scholar 

  42. Tripathi N, Cotten CM, Smith PB (2012) Antibiotic use and misuse in the neonatal intensive care unit. Clin Perinatol 39:61–68

    Article  PubMed Central  PubMed  Google Scholar 

  43. Stockmann C, Spigarelli MG, Campbell SC, Constance JE, Courter JD, Thorell EA, Olson J, Sherwin CM (2014) Considerations in the pharmacologic treatment and prevention of neonatal sepsis. Paediatr Drugs 16:67–81

    Article  PubMed  Google Scholar 

  44. Kim YH, Chang SS, Kim YS, Kim EA, Yun SC, Kim KS, Pi SY (2007) Clinical outcomes in methicillin-resistant Staphylococcus aureus-colonized neonates in the neonatal intensive care unit. Neonatology 91:241–247

    Article  CAS  PubMed  Google Scholar 

  45. Morioka I, Yahata M, Shibata A, Miwa A, Yokota T, Jikimoto T, Nakamura M, Lee JJ, Yoshida H, Yamada H, Arakawa S, Iijima K (2013) Impact of pre-emptive contact precautions for outborn neonates on the incidence of healthcare-associated meticillin-resistant Staphylococcus aureus transmission in a Japanese neonatal intensive care unit. J Hosp Infect 84:66–70

    Article  CAS  PubMed  Google Scholar 

  46. Nelson MU, Gallagher PG (2012) Methicillin-resistant Staphylococcus aureus in the neonatal intensive care unit. Semin Perinatol 36:424–430

    Article  PubMed Central  PubMed  Google Scholar 

  47. Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (2014) Empfehlungen zur Prävention und Kontrolle von Methicillin-resistenten Staphylococcus aureus-Stämmen (MRSA) in medizinischen und pflegerischen Einrichtungen. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 57:696–732

    Google Scholar 

  48. Myers PJ, Marcinak J, David MZ, Zychowski DL, Boyle-Vavra S, Weber S, Daum RS (2011) Universal admission screening for methicillin-resistant Staphylococcus aureus in a level IIID neonatal intensive care unit: the first 9 months. Infect Control Hosp Epidemiol 32:398–400

    Article  PubMed  Google Scholar 

  49. Lepelletier D, Corvec S, Caillon J, Reynaud A, Roze JC, Gras-Leguen C (2009) Eradication of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit: which measures for which success? Am J Infect Control 37:195–200

    Article  PubMed  Google Scholar 

  50. Klotz M, Zimmermann S, Opper S, Heeg K, Mutters R (2005) Possible risk for re-colonization with methicillin-resistant Staphylococcus aureus (MRSA) by faecal transmission. Int J Hyg Environ Health 208:401–405

    Article  CAS  PubMed  Google Scholar 

  51. Acton DS, Plat-Sinnige MJ, van Wamel W, de Groot N, van Belkum A (2009) Intestinal carriage of Staphylococcus aureus: how does its frequency compare with that of nasal carriage and what is its clinical impact? Eur J Clin Microbiol Infect Dis 28:115–127

    Article  CAS  PubMed  Google Scholar 

  52. Thorburn K, Taylor N, Saladi SM, van Saene HK (2006) Use of surveillance cultures and enteral vancomycin to control methicillin-resistant Staphylococcus aureus in a paediatric intensive care unit. Clin Microbiol Infect 12:35–42

    Article  CAS  PubMed  Google Scholar 

  53. Rosenthal A, White D, Churilla S, Brodie S, Katz KC (2006) Optimal surveillance culture sites for detection of methicillin-resistant Staphylococcus aureus in newborns. J Clin Microbiol 44:4234–4236

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  54. Geffers C, Gastmeier P (2011) Nosocomial infections and multidrug-resistant organisms in Germany: epidemiological data from KISS (the Hospital Infection Surveillance System). Dtsch Arztebl Int 108:87–93

    PubMed Central  PubMed  Google Scholar 

  55. Geffers C, Haller S, Heller G, Gortner L, Göpel W, Bührer C (2014) Nosokomiale Infektionen bei Neugeborenen – Wo stehen wir in Deutschland? Monatsschr Kinderheilkd 162:385–393

    Article  Google Scholar 

  56. Gregory ML, Eichenwald EC, Puopolo KM (2009) Seven-year experience with a surveillance program to reduce methicillin-resistant Staphylococcus aureus colonization in a neonatal intensive care unit. Pediatrics 123:e790–796

    Article  PubMed  Google Scholar 

  57. Karchmer TB, Durbin LJ, Simonton BM, Farr BM (2002) Cost-effectiveness of active surveillance cultures and contact/droplet precautions for control of methicillin-resistant Staphylococcus aureus. J Hosp Infect 51:126–132

    Article  CAS  PubMed  Google Scholar 

  58. Landelle C, Pagani L, Harbarth S (2013) Is patient isolation the single most important measure to prevent the spread of multidrug-resistant pathogens? Virulence 4:163–171

    Article  PubMed Central  PubMed  Google Scholar 

  59. Geva A, Wright SB, Baldini LM, Smallcomb JA, Safran C, Gray JE (2011) Spread of methicillin-resistant Staphylococcus aureus in a large tertiary NICU: network analysis. Pediatrics 128:e1173–1180

    Article  PubMed Central  PubMed  Google Scholar 

  60. Morel AS, Wu F, Della-Latta P, Cronquist A, Rubenstein D, Saiman L (2002) Nosocomial transmission of methicillin-resistant Staphylococcus aureus from a mother to her preterm quadruplet infants. Am J Infect Control 30:170–173

    Article  PubMed  Google Scholar 

  61. Chapman AK, Aucott SW, Gilmore MM, Advani S, Clarke W, Milstone AM (2013) Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates. J Perinatol 33:768–771

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  62. Chapman AK, Aucott SW, Milstone AM (2012) Safety of chlorhexidine gluconate used for skin antisepsis in the preterm infant. J Perinatol 32:4–9

    Article  CAS  PubMed  Google Scholar 

  63. Quach C, Milstone AM, Perpete C, Bonenfant M, Moore DL, Perreault T (2014) Chlorhexidine bathing in a tertiary care neonatal intensive care unit: impact on central line-associated bloodstream infections. Infect Control Hosp Epidemiol 35:158–163

    Article  PubMed  Google Scholar 

  64. Milstone AM, Budd A, Shepard JW, Ross T, Aucott S, Carroll KC, Perl TM (2010) Role of decolonization in a comprehensive strategy to reduce methicillin-resistant Staphylococcus aureus infections in the neonatal intensive care unit: an observational cohort study. Infect Control Hosp Epidemiol 31:558–560

    Article  PubMed Central  PubMed  Google Scholar 

  65. Sethi K, McKechnie L (2014) PC.28 changing epidemiology of Staphylococcus aureus in neonatal intensive care unit (NICU) at Leeds, 2008–2013. Arch Dis Child Fetal Neonatal Ed 99(Suppl 1):A45

    Article  Google Scholar 

  66. Milstone AM, Elward A, Song X, Zerr DM, Orscheln R, Speck K, Obeng D, Reich NG, Coffin SE, Perl TM (2013) Daily chlorhexidine bathing to reduce bacteraemia in critically ill children: a multicentre, cluster-randomised, crossover trial. Lancet 381:1099–1106

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  67. Bertin ML, Vinski J, Schmitt S, Sabella C, Danziger-Isakov L, McHugh M, Procop GW, Hall G, Gordon SM, Goldfarb J (2006) Outbreak of Methicillin-Resistant Staphylococcus aureus colonization and infection in a Neonatal Intensive Care Unit Epidemiologically linked to a healthcare worker with Chronic Otitis. Infect Control Hosp Epidemiol 27:581–585

    Article  PubMed  Google Scholar 

  68. Stein M, Navon-Venezia S, Chmelnitsky I, Kohelet D, Schwartz O, Agmon O, Somekh E (2006) An outbreak of new, nonmultidrug-resistant, methicillin-resistant Staphylococcus aureus strain (sccmec type iiia variant-1) in the neonatal intensive care unit transmitted by a staff member. Pediatr Infect Dis J 25:557–559

    Article  PubMed  Google Scholar 

  69. Hawkins G, Stewart S, Blatchford O, Reilly J (2011) Should healthcare workers be screened routinely for meticillin-resistant Staphylococcus aureus? A review of the evidence. J Hosp Infect 77:285–289

    Article  CAS  PubMed  Google Scholar 

  70. Park DA, Lee SM, Peck KR, Joo EJ, Oh EG (2013) Impact of methicillin-resistance on mortality in children and neonates with Staphylococcus aureus bacteremia: a meta-analysis. Infect Chemother 45:202–210

    Article  PubMed Central  PubMed  Google Scholar 

  71. Grant PS, Charns LG, Rawot BW, Benedetti SG (2008) Consideration to culture health care workers related to increased methicillin-resistant Staphylococcus aureus activity in a neonatal intensive care unit. Am J Infect Control 36:638–643

    Article  PubMed  Google Scholar 

  72. David MD, Kearns AM, Gossain S, Ganner M, Holmes A (2006) Community-associated meticillin-resistant Staphylococcus aureus: nosocomial transmission in a neonatal unit. J Hosp Infect 64:244–250

    Article  CAS  PubMed  Google Scholar 

  73. Healy CM, Hulten KG, Palazzi DL, Campbell JR, Baker CJ (2004) Emergence of new strains of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Clin Infect Dis 39:1460–1466

    Article  PubMed  Google Scholar 

  74. Vonberg RP, Stamm-Balderjahn S, Hansen S, Zuschneid I, Ruden H, Behnke M, Gastmeier P (2006) How often do asymptomatic healthcare workers cause methicillin-resistant Staphylococcus aureus outbreaks? A systematic evaluation. Infect Control Hosp Epidemiol 27:1123–1127

    Article  PubMed  Google Scholar 

  75. Albrich WC, Harbarth S (2008) Health-care workers: source, vector, or victim of MRSA? Lancet Infect Dis 8:289–301

    Article  PubMed  Google Scholar 

  76. Kramer A, Schwebke I, Kampf G (2006) How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis 6:130

    Article  PubMed Central  PubMed  Google Scholar 

  77. Dancer SJ (2008) Importance of the environment in methicillin-resistant Staphylococcus aureus acquisition: the case for hospital cleaning. Lancet Infect Dis 8:101–113

    Article  PubMed  Google Scholar 

  78. Song X, Perencevich E, Campos J, Short BL, Singh N (2010) Clinical and economic impact of methicillin-resistant Staphylococcus aureus colonization or infection on neonates in intensive care units. Infect Control Hosp Epidemiol 31:177–182

    Article  PubMed  Google Scholar 

  79. Haley RW, Cushion NB, Tenover FC, Bannerman TL, Dryer D, Ross J, Sanchez PJ, Siegel JD (1995) Eradication of endemic methicillin-resistant Staphylococcus aureus infections from a neonatal intensive care unit. J Infect Dis 171:614–624

    Article  CAS  PubMed  Google Scholar 

  80. Schultz ED, Tanaka DT, Goldberg RN, Benjamin DK Jr., Smith PB (2009) Effect of methicillin-resistant Staphylococcus aureus colonization in the neonatal intensive care unit on total hospital cost. Infect Control Hosp Epidemiol 30:383–385

  81. Sengupta A, Rand C, Perl TM, Milstone AM (2011) Knowledge, awareness, and attitudes regarding methicillin-resistant Staphylococcus aureus among caregivers of hospitalized children. J Pediatr 158:416–421

    Article  PubMed Central  PubMed  Google Scholar 

  82. Vonberg RP, Weitzel-Kage D, Behnke M, Gastmeier P (2010) Worldwide outbreak database: the largest collection of nosocomial outbreaks. Infection 39:29–34

    Article  PubMed  Google Scholar 

  83. Stone SP, Cooper BS, Kibbler CC, Cookson BD, Roberts JA, Medley GF, Duckworth G, Lai R, Ebrahim S, Brown EM, Wiffen PJ, Davey PG (2007) The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection. J Antimicrob Chemother 59:833–840

    Article  CAS  PubMed  Google Scholar 

  84. Hansen S, Stamm-Balderjahn S, Zuschneid I, Behnke M, Ruden H, Vonberg RP, Gastmeier P (2007) Closure of medical departments during nosocomial outbreaks: data from a systematic analysis of the literature. J Hosp Infect 65:348–353

    Article  CAS  PubMed  Google Scholar 

  85. Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (2002) Ausbruchmanagement und strukturiertes Vorgehen bei gehäuftem Auftreten nosokomialer Infektionen. Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut. Bundesgesundheitsbl Gesundheitsforsch- Gesundheitsschutz 45:180–186

    Article  Google Scholar 

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Die Autoren dieses Beitrages sind den Mitgliedern der Arbeitsgruppe neonatologische Intensivmedizin der KRINIKO zu außerordentlichem Dank für ihre ehrenamtliche Arbeit verpflichtet: Dr. Jürgen Christoph, Hannover, Prof. Dr. Christof Dame, Berlin, Dr. Tim Eckmanns, Berlin, Prof. Dr. Barbara Gärtner, Homburg, Dr. Christine Geffers, Berlin, Dr. Christian Gille, Tübingen, Priv. Doz. Dr. Christoph Härtel, Lübeck, Dr. Sebastian Haller, Berlin, Prof. Dr. Dominik Hartl, Tübingen, Dr. Matthias Marschal, Tübingen, Prof. Dr. Andreas Müller, Bonn, Priv. Doz. Dr. med. Lutz von Müller, Homburg

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Authors and Affiliations

  1. Robert Koch-Institut, Berlin, Deutschland

    Martina Kraus-Haas & Martin Mielke

  2. Klinik für Pädiatrische Onkologie und Hämatologie, Universitätsklinikum des Saarlandes, Kirrberger Straße, Gebäude 9, 66421, Homburg/Saar, Deutschland

    Arne Simon

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  1. Martina Kraus-Haas
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  2. Martin Mielke
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  3. Arne Simon
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Correspondence to Arne Simon.

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M. Kraus-Haas, M. Mielke und A. Simon geben an, dass kein Interessenkonflikt besteht.

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Kraus-Haas, M., Mielke, M. & Simon, A. Literatur-Update zu Staphylococcus-aureus-Ausbrüchen auf neonatologischen Intensivpflegestationen (2010–2013). Bundesgesundheitsbl. 58, 323–338 (2015). https://doi.org/10.1007/s00103-014-2115-0

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  • DOI: https://doi.org/10.1007/s00103-014-2115-0

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