Der Anaesthesist

, Volume 57, Issue 3, pp 223–230 | Cite as

„Target controlled infusion“ (TCI) – ein Konzept mit Zukunft?

Standortbestimmung, Handlungsempfehlungen und Blick in die Zukunft
  • S. Schraag
  • S. Kreuer
  • J. Bruhn
  • C. Frenkel
  • S. Albrecht
Leitthema

Zusammenfassung

„Target controlled infusion“ (TCI) hat in den letzten 10 Jahren Entwicklung und Praxis der i.v.-Anästhesie nachhaltig beeinflusst, sodass wesentliche Fortschritte der Medikamentenapplikation in der perioperativen Medizin erreicht werden konnten. Neuere und aktuelle Entwicklungen wie „open TCI“ und die Verfügbarkeit von generischen Anästhetika zusammen mit modernen Infusionsspritzenpumpen ermöglichen, dass TCI ein fester Bestandteil im Methodenspektrum der Anästhesie werden kann und nicht mehr nur Spezialisten sowie Enthusiasten vorbehalten bleibt. Die vorliegende Übersicht beschreibt die Grundlagen der Zufuhr von i.v.-Anästhetika mit TCI und gibt Handlungsempfehlungen für eine erfolgreiche Implementierung in die klinische Praxis.

Schlüsselwörter

„Target controlled infusion“ Propofol Pharmakokinetik Intravenöse Anästhesie Monitoring 

Target-controlled infusion (TCI) – a concept with a future?

State-of-the-art, treatment recommendations and a look into the future

Abstract

Over the last 10 years the technique of target-controlled infusion (TCI) has substantially influenced the development and practice of intravenous anaesthesia. It opened the possibility of many new and exciting applications of perioperative anaesthetic care. More recent and current developments, such as open TCI (target-controlled infusion) and the availability of generic anaesthetic agents combined with modern infusion pumps, means that TCI can become a standard procedure in anaesthesia and is no longer just a research tool for specialists and enthusiasts. This review explains the fundamentals and applications of intravenous drug delivery by TCI and gives practice guidelines to successfully implement the technique into clinical practice. The aim is to provide a comprehensive reference based on clinically proven evidence.

Keywords

Target-controlled infusion Propofol Pharmacokinetics Intravenous anaesthesia Monitoring 

Notes

Interessenkonflikt

Alle Autoren sind Mitglied eines von FreseniusKabi, Bad Homburg, unterstützen „Target Controlled Infusion Expert Board“. Dieses Projekt wurde durch ein Grant von FreseniusKabi unterstützt.

Supplementary material

101_2008_1329_MO1_ESM.xls (2 mb)
Excel-Datei zu Propofol/Berechnungen (2.094 KB)

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Copyright information

© Springer Medizin Verlag 2008

Authors and Affiliations

  • S. Schraag
    • 1
  • S. Kreuer
    • 2
  • J. Bruhn
    • 3
  • C. Frenkel
    • 4
  • S. Albrecht
    • 5
  1. 1.Department of Perioperative MedicineGolden Jubilee National HospitalClydebank, GlasgowScotland, UK
  2. 2.Klinik für Anästhesiologie, Intensivmedizin und SchmerztherapieHomburg/SaarHomburg/SaarDeutschland
  3. 3.Department of AnaesthesiologyRadboud University Nijmegen Medical CentreNijmegenNijmegenNiederlande
  4. 4.Klinik für AnästhesiologieStädtisches Klinikum LüneburgLüneburgDeutschland
  5. 5.Anästhesiologische KlinikUniversitätsklinikum ErlangenErlangenDeutschland

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