Der Anaesthesist

, Volume 57, Issue 5, pp 491–498 | Cite as

Medikamente zur postoperativen Schmerztherapie: Bewährtes und Neues

Teil 2: Opioide, Ketamin und Gabapentinoide
Klinische Pharmakologie

Zusammenfassung

In dem Übersichtsartikel (Teil 1) wurden perioperative Aspekte der Anwendung von Nichtopioiden (Paracetamol, Metamizol, traditionelle nichtsteroidale antiphlogistische Rheumatika, Coxibe) diskutiert. Im Teil 2 folgen nun die Opioide (schwach: Tramadol, Tilidin mit Naloxon; stark: Piritramid, Morphin, Oxycodon, Hydromorphon, Fentanyl, Methadon, Buprenorphin) und einige Koanalgetika (Gabapentinoide, Ketamin). Zentraler Punkt der Übersicht ist die Darstellung von Nutzen, Risiken und Kosten einiger Substanzen, um dem Anwender die Differenzialindikation zu erleichtern. Neue Aspekte der Anwendung von Gabapentinoiden und Ketamin werden diskutiert.

Schlüsselwörter

Postoperative Schmerztherapie Opioide Gabapentinoide Ketamin Kombination mit Nichtopioiden 

Drugs for postoperative analgesia: routine and new aspects

Part 2: Opioids, ketamine and gabapentinoids

Abstract

In part 1 of this review, perioperative aspects of the use of non-opioids (acetaminophene, dipyrone, traditional NSAR, coxibs) were discussed. In part 2 the perioperative aspects of opioids (weak opioids: tramadol, tilidine with naloxone, strong opioids: morphine, piritramide, oxycodone, hydromorphone, fentanyl, methadone, buprenorphine) and coanalgesics (gabapentinoids; ketamine) will now be presented. The main aim of the review is to describe the use, risks and cost of some substances to facilitate the differential indication. New aspects concerning the use of gabapentinoids and ketamine are discussed.

Keywords

Postoperative analgesia Opioids Gabapentinoids Ketamine Combination with non-opioids 

Notes

Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehungen hin: Der korrespondierende Autor hat Vorträge auf Honorarbasis für die Firmen Aventis, Bristol Myers-Squibb, Grünenthal, Janssen-Cilag, MSD und Mundipharma gehalten.

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Copyright information

© Springer Medizin Verlag 2008

Authors and Affiliations

  1. 1.Klinik für AnästhesiologieJohannes Gutenberg-UniversitätMainzDeutschland

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